MolNFT v1 · #172164 · protein
Cryo-EM structure of respiratory complex I from mus musculus inhibited by piericidin a at 3.0 a
6ZTQ: “Cryo-EM structure of respiratory complex I from mus musculus inhibited by piericidin a at 3.0 a”. Electron microscopy, 11 ligands (3PE, CDL, SF4). MolNFT v1 #172164 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6ZTQ
- Type
- protein
- Length
- 8,182 residues
- Chains
- 45
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P03899, Q9DC70, Q9DCT2, Q91WD5, Q9D6J6, Q91YT0, Q91VD9, P03888, Q8K3J1, P03925, P03903, P03921, P03911, P03893, Q99LC3, Q9DC69, Q9CXZ1, P52503, Q9CQ75, Q9CR21, Q9CPP6, Q9CQZ5, Q9DCJ5, G5E814, Q9ERS2, O35683, Q9CQ91, Q9CQY9, Q9CQ54, Q99LY9, P0DN34, O09111, Q9CQH3, Q3UIU2, Q9CPU2, Q9CQZ6, Q9D6J5, Q9CQC7, Q9CQJ8, Q9CR61, Q9DCS9, Q7TMF3, Q9Z1P6, Q8BK30
- Ligands
- 3PE, CDL, SF4, PC1, FES, EHZ, HQH, FMN, ATP, NDP, ZN
Structure
electron microscopy · 45 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 115 | — | P03899 |
| B | — | protein | 156 | — | Q9DC70 |
| C | — | protein | 207 | — | Q9DCT2 |
| D | — | protein | 430 | — | Q91WD5 |
| E | — | protein | 212 | — | Q9D6J6 |
| F | — | protein | 428 | — | Q91YT0 |
| G | — | protein | 688 | — | Q91VD9 |
| H | — | protein | 318 | — | P03888 |
| I | — | protein | 178 | — | Q8K3J1 |
| J | — | protein | 171 | — | P03925 |
| K | — | protein | 98 | — | P03903 |
| L | — | protein | 606 | — | P03921 |
| M | — | protein | 459 | — | P03911 |
| N | — | protein | 344 | — | P03893 |
| O | — | protein | 320 | — | Q99LC3 |
| P | — | protein | 342 | — | Q9DC69 |
| Q | — | protein | 125 | — | Q9CXZ1 |
| R | — | protein | 94 | — | P52503 |
| S | — | protein | 83 | — | Q9CQ75 |
| T | — | protein | 76 | — | Q9CR21 |
| U | — | protein | 86 | — | Q9CR21 |
| V | — | protein | 114 | — | Q9CPP6 |
| W | — | protein | 114 | — | Q9CQZ5 |
| X | — | protein | 171 | — | Q9DCJ5 |
| Y | — | protein | 140 | — | G5E814 |
| Z | — | protein | 141 | — | Q9ERS2 |
| a | — | protein | 68 | — | O35683 |
| b | — | protein | 80 | — | Q9CQ91 |
| c | — | protein | 48 | — | Q9CQY9 |
| d | — | protein | 120 | — | Q9CQ54 |
| e | — | protein | 105 | — | Q99LY9 |
| f | — | protein | 53 | — | P0DN34 |
| g | — | protein | 101 | — | O09111 |
| h | — | protein | 138 | — | Q9CQH3 |
| i | — | protein | 94 | — | Q3UIU2 |
| j | — | protein | 62 | — | Q9CPU2 |
| k | — | protein | 75 | — | Q9CQZ6 |
| l | — | protein | 154 | — | Q9D6J5 |
| m | — | protein | 126 | — | Q9CQC7 |
| n | — | protein | 177 | — | Q9CQJ8 |
| o | — | protein | 111 | — | Q9CR61 |
| p | — | protein | 169 | — | Q9DCS9 |
| q | — | protein | 144 | — | Q7TMF3 |
| r | — | protein | 100 | — | Q9Z1P6 |
| s | — | protein | 41 | — | Q8BK30 |
Ligands and binding sites
- 3PE · 1,2-diacyl-sn-glycero-3-phosphoethanolamine · ligand · 9 copies · chains D, H, I, Z, b, A, J, a, K, L, M, N, g, Y, h, i, l
- CDL · Cardiolipin · ligand · 7 copies · chains L, M, h, N, O, d, X, f, e, g, i, p, H, a, q, r
- SF4 · Iron/sulfur cluster · ligand · 6 copies · chains B, D, F, G, I
- PC1 · 1,2-diacyl-sn-glycero-3-phosphocholine · ligand · 4 copies · chains B, H, q, A, P, J, I, Z, r
- FES · Fe2/s2 (inorganic) cluster · ligand · 2 copies · chains E, G
- EHZ · ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate · ligand · 2 copies · chains T, W, U, n
- HQH · Piericidin A · ligand · chains B, D
- FMN · Flavin mononucleotide · ligand · chains F
- ATP · Adenosine-5'-triphosphate · ligand · chains O
- NDP · Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate · ligand · chains B, P
- ZN · Zinc ion · metal · chains R
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6ZTQ · Cryo-EM structure of respiratory complex I from Mus musculus inhibited by piericidin A at… · the same entry in another collection · chain I against I, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03899
- Every structure of UniProt Q9DC70
- Every structure of UniProt Q9DCT2
- Every structure of UniProt Q91WD5
- Every structure of UniProt Q9D6J6
- Every structure of UniProt Q91YT0
- Every structure of UniProt Q91VD9
- Every structure of UniProt P03888
- Every structure of UniProt Q8K3J1
- Every structure of UniProt P03925
- Every structure of UniProt P03903
- Every structure of UniProt P03921
- Every structure of UniProt P03911
- Every structure of UniProt P03893
- Every structure of UniProt Q99LC3
- Every structure of UniProt Q9DC69
- Every structure of UniProt Q9CXZ1
- Every structure of UniProt P52503
- Every structure of UniProt Q9CQ75
- Every structure of UniProt Q9CR21
- Every structure of UniProt Q9CPP6
- Every structure of UniProt Q9CQZ5
- Every structure of UniProt Q9DCJ5
- Every structure of UniProt G5E814
- Every structure of UniProt Q9ERS2
- Every structure of UniProt O35683
- Every structure of UniProt Q9CQ91
- Every structure of UniProt Q9CQY9
- Every structure of UniProt Q9CQ54
- Every structure of UniProt Q99LY9
- Every structure of UniProt P0DN34
- Every structure of UniProt O09111
- Every structure of UniProt Q9CQH3
- Every structure of UniProt Q3UIU2
- Every structure of UniProt Q9CPU2
- Every structure of UniProt Q9CQZ6
- Every structure of UniProt Q9D6J5
- Every structure of UniProt Q9CQC7
- Every structure of UniProt Q9CQJ8
- Every structure of UniProt Q9CR61
- Every structure of UniProt Q9DCS9
- Every structure of UniProt Q7TMF3
- Every structure of UniProt Q9Z1P6
- Every structure of UniProt Q8BK30
- Elsewhere: RCSB PDB 6ZTQ · PDBe 6ZTQ · UniProt P03899 · UniProt Q9DC70 · UniProt Q9DCT2 · UniProt Q91WD5 · UniProt Q9D6J6 · UniProt Q91YT0 · UniProt Q91VD9 · UniProt P03888 · UniProt Q8K3J1 · UniProt P03925 · UniProt P03903 · UniProt P03921 · UniProt P03911 · UniProt P03893 · UniProt Q99LC3 · UniProt Q9DC69 · UniProt Q9CXZ1 · UniProt P52503 · UniProt Q9CQ75 · UniProt Q9CR21 · UniProt Q9CPP6 · UniProt Q9CQZ5 · UniProt Q9DCJ5 · UniProt G5E814 · UniProt Q9ERS2 · UniProt O35683 · UniProt Q9CQ91 · UniProt Q9CQY9 · UniProt Q9CQ54 · UniProt Q99LY9 · UniProt P0DN34 · UniProt O09111 · UniProt Q9CQH3 · UniProt Q3UIU2 · UniProt Q9CPU2 · UniProt Q9CQZ6 · UniProt Q9D6J5 · UniProt Q9CQC7 · UniProt Q9CQJ8 · UniProt Q9CR61 · UniProt Q9DCS9 · UniProt Q7TMF3 · UniProt Q9Z1P6 · UniProt Q8BK30
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