UniProt Q9DC70
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (Q9DC70)
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (UniProt Q9DC70), EC 1.6.5.3, 1.6.99.3: 53 experimental structures and 1 predicted model on GenesisL1, 11 ligands bound, 262 pockets. Binding sites…
- UniProt
- Q9DC70
- Protein
- NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
- EC
- 1.6.5.3, 1.6.99.3, 7.1.1.2
- Experimental structures
- 53
- Predicted models
- 1
- Ligands
- 11
- Pockets
- 262 · 45 records with a druggable one
Structures
54 records of Q9DC70 in the MolNFT archive: 53 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6G2J | Mouse mitochondrial complex I in the active state | electron microscopy | B | SF4, PC1, NDP | 3 (best 0.88) |
| 6G2J | Mouse mitochondrial complex I in the active state | electron microscopy | B | SF4, PC1, NDP | — |
| 6G72 | Mouse mitochondrial complex I in the deactive state | electron microscopy | B | SF4, NDP | 2 (best 0.87) |
| 6G72 | Mouse mitochondrial complex I in the deactive state | electron microscopy | B | SF4, NDP | — |
| 6ZR2 | Cryo-EM structure of respiratory complex I in the active state from Mus musculus at 3.1 A | electron microscopy | B | SF4, PC1, NDP | 5 (best 0.87) |
| 6ZR2 | Cryo-EM structure of respiratory complex I in the active state from mus musculus at 3.1 a | electron microscopy | B | SF4, PC1, NDP | — |
| 6ZTQ | Cryo-EM structure of respiratory complex I from Mus musculus inhibited by piericidin A at 3.0 A | electron microscopy | B | SF4, PC1, HQH, NDP | 4 (best 0.88) |
| 6ZTQ | Cryo-EM structure of respiratory complex I from mus musculus inhibited by piericidin a at 3.0 a | electron microscopy | B | SF4, PC1, HQH, NDP | — |
| 7AK5 | Cryo-EM structure of respiratory complex I in the deactive state from Mus musculus at 3.2 A | electron microscopy | B | SF4, PC1, NDP | — |
| 7AK5 | Cryo-EM structure of respiratory complex I in the deactive state from mus musculus at 3.2 a | electron microscopy | B | SF4, PC1, NDP | — |
| 7AK6 | Cryo-EM structure of ND6-P25L mutant respiratory complex I from Mus musculus at 3.8 A | electron microscopy | B | SF4, PC1, NDP | 7 (best 0.85) |
| 7AK6 | Cryo-EM structure of ND6-P25L mutant respiratory complex I from mus musculus at 3.8 a | electron microscopy | B | SF4, PC1, NDP | — |
| 7B93 | Cryo-EM structure of mitochondrial complex I from Mus musculus inhibited by IACS-2858 at 3.0 A | electron microscopy | B | SF4, PC1, T2Q, NDP | 4 (best 0.88) |
| 7B93 | Cryo-EM structure of mitochondrial complex I from mus musculus inhibited by iacs-2858 at 3.0 a | electron microscopy | B | SF4, PC1, T2Q, NDP | — |
| 7PSA | The acetogenin-bound complex I of Mus musculus resolved to 3.4 angstroms | electron microscopy | B | SF4, PC1, 88I, NDP | 5 (best 0.88) |
| 8C2S | Cryo-EM structure NDUFS4 knockout complex I from Mus musculus heart (Class 1). | electron microscopy | B | SF4, PC1, NAP | 3 (best 0.87) |
| 8CA3 | Cryo-EM structure NDUFS4 knockout complex I from Mus musculus heart (Class 2). | electron microscopy | B | SF4, PC1, UQ9, NDP | 3 (best 0.88) |
| 8CA5 | Cryo-EM structure NDUFS4 knockout complex I from Mus musculus heart (Class 3). | electron microscopy | B | SF4, PC1, UQ9, NDP | 3 (best 0.88) |
| 8IAO | Respiratory complex CI:CIII2, type I, Wild type mouse under thermoneutral temperature | electron microscopy | B | SF4, UQ1, UQ9, NDP, PC1 | 4 (best 0.87) |
| 8IAP | Respiratory complex Peripheral Arm of CI, focus-refined map of type I, Wild type mouse under… | electron microscopy | B | SF4, UQ1, UQ9, NDP, PC1 | 10 (best 0.86) |
| 8IB4 | Respiratory complex CI:CIII2, type IA, Wild type mouse under cold temperature | electron microscopy | B | SF4, UQ1, PC1, UQ9, NDP | 3 (best 0.87) |
| 8IB5 | Respiratory complex Peripheral Arm of CI, focus-refined map of type IA, Wild type mouse under cold… | electron microscopy | B | SF4, UQ1, PC1, UQ9, NDP | 9 (best 0.87) |
| 8IB9 | Respiratory complex CI:CIII2, type IB, Wild type mouse under cold temperature | electron microscopy | B | SF4, UQ1, PC1, UQ9, NDP | 4 (best 0.87) |
| 8IBA | Respiratory complex Peripheral Arm of CI, focus-refined map of type IB, Wild type mouse under cold… | electron microscopy | B | SF4, UQ1, PC1, UQ9, NDP | 8 (best 0.87) |
| 8IBD | Respiratory complex CI:CIII2, type II, Wild type mouse under cold temperature | electron microscopy | B | SF4, UQ1, PC1, UQ9, NDP | 5 (best 0.87) |
| 8IBE | Respiratory complex Peripheral Arm of CI, focus-refined map of type II, Wild type mouse under cold… | electron microscopy | B | SF4, UQ1, PC1, UQ9, NDP | 7 (best 0.87) |
| 8IC2 | Respiratory complex CI:CIII2, type I, PERK -/- mouse under cold temperature | electron microscopy | B | SF4, UQ1, PC1, UQ9 | 3 (best 0.89) |
| 8IC3 | Respiratory complex Peripheral Arm of CI, focus-refined map of type I, PERK -/- mouse under cold… | electron microscopy | B | SF4, UQ1, PC1, UQ9 | 9 (best 0.89) |
| 8OLT | Mitochondrial complex I from Mus musculus in the active state bound with piericidin A | electron microscopy | B | SF4, PC1, HQH, NDP | 4 (best 0.88) |
| 8OM1 | Mitochondrial complex I from Mus musculus in the active state | electron microscopy | B | SF4, PC1, NDP | 4 (best 0.88) |
| 8PW5 | CS respirasome from murine liver | electron microscopy | 6 | SF4, 3PE, PC1, NDP | 3 (best 0.88) |
| 8PW6 | C respirasome from murine liver | electron microscopy | 6 | SF4, 3PE, PC1, NDP | 4 (best 0.89) |
| 8PW7 | A respirasome from murine liver | electron microscopy | 6 | SF4, 3PE, PC1, NDP | 4 (best 0.89) |
| 8RGP | Closed Complex I from murine brain | electron microscopy | 6 | SF4, 3PE, PC1, UQ, NDP | 4 (best 0.88) |
| 8RGQ | Open Complex I from murine liver | electron microscopy | 6 | SF4, 3PE, PC1, NDP | 4 (best 0.87) |
| 8RGR | Closed Complex I from murine liver | electron microscopy | 6 | SF4, 3PE, PC1, UQ, NDP | 5 (best 0.88) |
| 8RGT | Open Complex I from murine brain | electron microscopy | 6 | SF4, 3PE, PC1, NDP | 5 (best 0.86) |
| 8XNL | Respiratory complex Peripheral Arm of CI, close form A, focus-refined map of type I, Wild type… | electron microscopy | B | SF4, UQ9, NDP, PC1 | 9 (best 0.88) |
| 8XNM | Respiratory complex Peripheral Arm of CI, close form B, focus-refined map of type I, Wild type… | electron microscopy | B | SF4, UQ9, NDP, PC1 | 8 (best 0.89) |
| 8XNN | Respiratory complex Peripheral Arm of CI, open form A, focus-refined map of type I, Wild type mouse… | electron microscopy | B | SF4, UQ9, NDP, PC1 | 9 (best 0.90) |
| 8XNO | Respiratory complex Peripheral Arm of CI, close form A, focus-refined map of type IA, Wild type… | electron microscopy | B | SF4, PC1, UQ1, UQ9, NDP | 8 (best 0.89) |
| 8XNP | Respiratory complex Peripheral Arm of CI, close form B, focus-refined map of type IA, Wild type… | electron microscopy | B | SF4, UQ9, PC1, NDP | 8 (best 0.89) |
| 8XNQ | Respiratory complex Peripheral Arm of CI, open form A, focus-refined map of type IA, Wild type… | electron microscopy | B | SF4, UQ1, PC1, UQ9, NDP | 7 (best 0.88) |
| 8XNR | Respiratory complex Peripheral Arm of CI, close form A, focus-refined map of type IB, Wild type… | electron microscopy | B | SF4, PC1, UQ1, UQ9, NDP | 8 (best 0.89) |
| 8XNS | Respiratory complex Peripheral Arm of CI, close form B, focus-refined map of type IB, Wild type… | electron microscopy | B | SF4, UQ9, PC1, NDP | 8 (best 0.89) |
| 8XNT | Respiratory complex Peripheral Arm of CI, close form C, focus-refined map of type IB, Wild type… | electron microscopy | B | SF4, PC1, NDP | 8 (best 0.86) |
| 8XNU | Respiratory complex Peripheral Arm of CI, open form A, focus-refined map of type IB, Wild type… | electron microscopy | B | SF4, UQ9, NDP | 8 (best 0.88) |
| 8XNV | Respiratory complex Peripheral Arm of CI, close form A, focus-refined map of type II, Wild type… | electron microscopy | B | SF4, PC1, UQ1, UQ9, NDP | 8 (best 0.88) |
| 8XNW | Respiratory complex Peripheral Arm of CI, close form B, focus-refined map of type II, Wild type… | electron microscopy | B | SF4, UQ9, PC1, NDP | 7 (best 0.87) |
| 8XNX | Respiratory complex Peripheral Arm of CI, open form A, focus-refined map of type II, Wild type… | electron microscopy | B | SF4, PC1, UQ9, NDP | 6 (best 0.89) |
| 8XNY | Respiratory complex Peripheral Arm of CI, open form B, focus-refined map of type II, Wild type… | electron microscopy | B | SF4, PC1, NDP | 6 (best 0.86) |
| 8XNZ | Respiratory complex Peripheral Arm of CI, close form A, focus-refined map of type I, PERK -/- mouse… | electron microscopy | B | SF4, UQ9, PC1 | 8 (best 0.89) |
| 8XO0 | Respiratory complex Peripheral Arm of CI, close form B, focus-refined map of type I, PERK -/- mouse… | electron microscopy | B | SF4, PC1 | 8 (best 0.89) |
| Q9DC70 | AlphaFold monomer V2.0 prediction for NADH dehydrogenase [ubiquinone] iron-sulfur protein 7… | predicted | A | — | — |
Ligands
- SF4 · Iron/sulfur cluster · in 53 records
- PC1 · 1,2-diacyl-sn-glycero-3-phosphocholine · in 50 records
- NDP · Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate · in 48 records
- UQ9 · Ubiquinone-9 · in 25 records
- UQ1 · Ubiquinone-1 · in 14 records
- 3PE · 1,2-diacyl-sn-glycero-3-phosphoethanolamine · in 7 records
- HQH · Piericidin A · in 3 records
- T2Q · 1-[[3-(4-methylsulfonylpiperidin-1-yl)phenyl]methyl]-5-[3-[4-(trifluoromethyloxy)phenyl]-1,2,4-oxadiazol-5-yl]pyridin-2-one · in 2 records
- UQ · Coenzyme Q10, (2Z,6E,10Z,14E,18E,22E,26Z)-isomer · in 2 records
- 88I · (3~{S},5~{S})-5-methyl-3-[(13~{R})-13-oxidanyl-13-[(2~{R},5~{R})-5-[(2~{R},5~{R})-5-[(1~{R})-1-oxidanylundecyl]oxolan-2-yl]oxolan-2-yl]tridecyl]oxolan-2-one · in 1 record
- NAP · Nadp nicotinamide-adenine-dinucleotide phosphate · in 1 record
Experiment against prediction
- 8XNY chain B against the predicted model Q9DC70: TM-score 0.99, RMSD 0.47 Å
- 8OLT chain B against the predicted model Q9DC70: TM-score 0.99, RMSD 0.52 Å
- 8OM1 chain B against the predicted model Q9DC70: TM-score 0.99, RMSD 0.53 Å
- 8RGR chain 6 against the predicted model Q9DC70: TM-score 0.99, RMSD 0.57 Å
- 8PW6 chain 6 against the predicted model Q9DC70: TM-score 0.99, RMSD 0.58 Å
- 8PW5 chain 6 against the predicted model Q9DC70: TM-score 0.99, RMSD 0.59 Å
- 8RGP chain 6 against the predicted model Q9DC70: TM-score 0.99, RMSD 0.59 Å
- 8PW7 chain 6 against the predicted model Q9DC70: TM-score 0.99, RMSD 0.59 Å
- 8CA5 chain B against the predicted model Q9DC70: TM-score 0.99, RMSD 0.68 Å
- 8CA3 chain B against the predicted model Q9DC70: TM-score 0.98, RMSD 0.71 Å
Elsewhere
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