GL1X · GenesisL1 explorer

MolNFT v1 · #149504 · protein

Mouse mitochondrial complex I in the active state

6G2J: “Mouse mitochondrial complex I in the active state”. Electron microscopy, 10 ligands (3PE, SF4, PC1). MolNFT v1 #149504 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB
6G2J
Type
protein
Length
8,164 residues
Chains
45
Method
electron microscopy
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt
P03899, Q9DC70, Q9DCT2, Q91WD5, Q9D6J6, Q91YT0, Q91VD9, P03888, Q8K3J1, P03925, P03903, P03921, P03911, P03893, Q99LC3, Q9DC69, Q9CXZ1, P52503, Q9CQ75, Q9CR21, Q9CPP6, Q9CQZ5, Q9DCJ5, G5E814, Q9ERS2, O35683, Q9CQ91, Q9CQY9, Q9CQ54, Q99LY9, P0DN34, O09111, Q9CQH3, Q3UIU2, Q9CPU2, Q9CQZ6, Q9D6J5, Q9CQC7, Q9CQJ8, Q9CR61, Q9DCS9, Q7TMF3, Q9Z1P6, Q8BK30
Ligands
3PE, SF4, PC1, CDL, FES, EHZ, FMN, ADP, NDP, ZN

Structure

electron microscopy · 45 distinct chains.

ChainMoleculeTypeResiduesSecondary structureUniProt
A—protein115—P03899
B—protein155—Q9DC70
C—protein206—Q9DCT2
D—protein430—Q91WD5
E—protein212—Q9D6J6
F—protein428—Q91YT0
G—protein688—Q91VD9
H—protein318—P03888
I—protein178—Q8K3J1
J—protein171—P03925
K—protein98—P03903
L—protein606—P03921
M—protein459—P03911
N—protein344—P03893
O—protein320—Q99LC3
P—protein342—Q9DC69
Q—protein125—Q9CXZ1
R—protein95—P52503
S—protein83—Q9CQ75
T—protein75—Q9CR21
U—protein88—Q9CR21
V—protein112—Q9CPP6
W—protein114—Q9CQZ5
X—protein171—Q9DCJ5
Y—protein140—G5E814
Z—protein139—Q9ERS2
a—protein67—O35683
b—protein83—Q9CQ91
c—protein47—Q9CQY9
d—protein119—Q9CQ54
e—protein104—Q99LY9
f—protein51—P0DN34
g—protein101—O09111
h—protein137—Q9CQH3
i—protein101—Q3UIU2
j—protein60—Q9CPU2
k—protein72—Q9CQZ6
l—protein152—Q9D6J5
m—protein124—Q9CQC7
n—protein176—Q9CQJ8
o—protein105—Q9CR61
p—protein170—Q9DCS9
q—protein144—Q7TMF3
r—protein99—Q9Z1P6
s—protein40—Q8BK30

Ligands and binding sites

  • 3PE · 1,2-diacyl-sn-glycero-3-phosphoethanolamine · ligand · 12 copies · chains J, K, A, H, Z, a, D, I, b, L, l, h, i, M, N, Y, g, f, O, d
  • SF4 · Iron/sulfur cluster · ligand · 6 copies · chains B, D, F, G, I
  • PC1 · 1,2-diacyl-sn-glycero-3-phosphocholine · ligand · 4 copies · chains H, J, P, I, Z, r, B, q, A
  • CDL · Cardiolipin · ligand · 4 copies · chains H, a, q, r, L, M, g, h, i, p, N, X, d, f
  • FES · Fe2/s2 (inorganic) cluster · ligand · 2 copies · chains E, F, G
  • EHZ · ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate · ligand · 2 copies · chains T, W, L, U, n
  • FMN · Flavin mononucleotide · ligand · chains F
  • ADP · Adenosine-5'-diphosphate · ligand · chains O
  • NDP · Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate · ligand · chains B, P
  • ZN · Zinc ion · metal · chains R

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

  • 6G2J · Mouse mitochondrial complex I in the active state · the same entry in another collection · chain I against I, TM-score 1.00

Analyse

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