UniProt Q8K3J1
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial (Q8K3J1)
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial (UniProt Q8K3J1), EC 1.6.5.3, 1.6.99.3: 50 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 198 pockets. Binding sites, druggability…
- UniProt
- Q8K3J1
- Protein
- NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
- EC
- 1.6.5.3, 1.6.99.3, 7.1.1.2
- Experimental structures
- 50
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 198 · 38 records with a druggable one
Structures
51 records of Q8K3J1 in the MolNFT archive: 50 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6G2J | Mouse mitochondrial complex I in the active state | electron microscopy | I | 3PE, PC1, SF4 | 3 (best 0.82) |
| 6G2J | Mouse mitochondrial complex I in the active state | electron microscopy | I | 3PE, PC1, SF4 | — |
| 6G72 | Mouse mitochondrial complex I in the deactive state | electron microscopy | I | SF4 | 3 (best 0.87) |
| 6G72 | Mouse mitochondrial complex I in the deactive state | electron microscopy | I | SF4 | — |
| 6ZR2 | Cryo-EM structure of respiratory complex I in the active state from Mus musculus at 3.1 A | electron microscopy | I | 3PE, PC1, SF4 | 2 (best 0.79) |
| 6ZR2 | Cryo-EM structure of respiratory complex I in the active state from mus musculus at 3.1 a | electron microscopy | I | 3PE, PC1, SF4 | — |
| 6ZTQ | Cryo-EM structure of respiratory complex I from Mus musculus inhibited by piericidin A at 3.0 A | electron microscopy | I | 3PE, SF4, PC1 | 5 (best 0.87) |
| 6ZTQ | Cryo-EM structure of respiratory complex I from mus musculus inhibited by piericidin a at 3.0 a | electron microscopy | I | 3PE, SF4, PC1 | — |
| 7AK5 | Cryo-EM structure of respiratory complex I in the deactive state from Mus musculus at 3.2 A | electron microscopy | I | PC1, 3PE, SF4, CDL | — |
| 7AK5 | Cryo-EM structure of respiratory complex I in the deactive state from mus musculus at 3.2 a | electron microscopy | I | PC1, 3PE, SF4, CDL | — |
| 7AK6 | Cryo-EM structure of ND6-P25L mutant respiratory complex I from Mus musculus at 3.8 A | electron microscopy | I | 3PE, SF4 | 3 (best 0.82) |
| 7AK6 | Cryo-EM structure of ND6-P25L mutant respiratory complex I from mus musculus at 3.8 a | electron microscopy | I | 3PE, SF4 | — |
| 7B93 | Cryo-EM structure of mitochondrial complex I from Mus musculus inhibited by IACS-2858 at 3.0 A | electron microscopy | I | PC1, 3PE, SF4 | 3 (best 0.88) |
| 7B93 | Cryo-EM structure of mitochondrial complex I from mus musculus inhibited by iacs-2858 at 3.0 a | electron microscopy | I | 3PE, PC1, SF4 | — |
| 7PSA | The acetogenin-bound complex I of Mus musculus resolved to 3.4 angstroms | electron microscopy | I | 3PE, SF4, PC1 | 3 (best 0.86) |
| 8C2S | Cryo-EM structure NDUFS4 knockout complex I from Mus musculus heart (Class 1). | electron microscopy | I | 3PE, SF4 | 1 (best 0.78) |
| 8CA3 | Cryo-EM structure NDUFS4 knockout complex I from Mus musculus heart (Class 2). | electron microscopy | I | 3PE, SF4 | 3 (best 0.79) |
| 8CA5 | Cryo-EM structure NDUFS4 knockout complex I from Mus musculus heart (Class 3). | electron microscopy | I | 3PE, SF4 | 2 (best 0.79) |
| 8IAO | Respiratory complex CI:CIII2, type I, Wild type mouse under thermoneutral temperature | electron microscopy | I | 3PE, PC1, SF4, CDL | — |
| 8IAP | Respiratory complex Peripheral Arm of CI, focus-refined map of type I, Wild type mouse under… | electron microscopy | I | 3PE, PC1, SF4, CDL | 8 (best 0.78) |
| 8IB4 | Respiratory complex CI:CIII2, type IA, Wild type mouse under cold temperature | electron microscopy | I | 3PE, PC1, SF4, CDL | — |
| 8IB5 | Respiratory complex Peripheral Arm of CI, focus-refined map of type IA, Wild type mouse under cold… | electron microscopy | I | 3PE, PC1, SF4, CDL | 7 (best 0.84) |
| 8IB9 | Respiratory complex CI:CIII2, type IB, Wild type mouse under cold temperature | electron microscopy | I | 3PE, PC1, SF4, CDL | — |
| 8IBD | Respiratory complex CI:CIII2, type II, Wild type mouse under cold temperature | electron microscopy | I | 3PE, SF4 | 1 (best 0.84) |
| 8IBE | Respiratory complex Peripheral Arm of CI, focus-refined map of type II, Wild type mouse under cold… | electron microscopy | I | 3PE, SF4 | 7 (best 0.83) |
| 8IC2 | Respiratory complex CI:CIII2, type I, PERK -/- mouse under cold temperature | electron microscopy | I | 3PE, PC1, SF4, CDL | — |
| 8IC3 | Respiratory complex Peripheral Arm of CI, focus-refined map of type I, PERK -/- mouse under cold… | electron microscopy | I | 3PE, PC1, SF4, CDL | 8 (best 0.78) |
| 8OLT | Mitochondrial complex I from Mus musculus in the active state bound with piericidin A | electron microscopy | I | PC1, SF4, 3PE | 4 (best 0.88) |
| 8OM1 | Mitochondrial complex I from Mus musculus in the active state | electron microscopy | I | PC1, SF4, 3PE | 3 (best 0.89) |
| 8PW5 | CS respirasome from murine liver | electron microscopy | 9 | SF4, PC1, 3PE | 2 (best 0.90) |
| 8PW6 | C respirasome from murine liver | electron microscopy | 9 | SF4, PC1, 3PE | 2 (best 0.90) |
| 8PW7 | A respirasome from murine liver | electron microscopy | 9 | SF4, PC1, 3PE | 3 (best 0.90) |
| 8RGP | Closed Complex I from murine brain | electron microscopy | 9 | SF4, PC1 | 2 (best 0.83) |
| 8RGQ | Open Complex I from murine liver | electron microscopy | 9 | 3PE, SF4, PC1 | 3 (best 0.90) |
| 8RGR | Closed Complex I from murine liver | electron microscopy | 9 | 3PE, SF4, PC1 | 4 (best 0.89) |
| 8XNL | Respiratory complex Peripheral Arm of CI, close form A, focus-refined map of type I, Wild type… | electron microscopy | I | 3PE, PC1, SF4, CDL | 8 (best 0.79) |
| 8XNM | Respiratory complex Peripheral Arm of CI, close form B, focus-refined map of type I, Wild type… | electron microscopy | I | PC1, SF4, CDL | 8 (best 0.87) |
| 8XNN | Respiratory complex Peripheral Arm of CI, open form A, focus-refined map of type I, Wild type mouse… | electron microscopy | I | 3PE, PC1, SF4, CDL | 9 (best 0.79) |
| 8XNO | Respiratory complex Peripheral Arm of CI, close form A, focus-refined map of type IA, Wild type… | electron microscopy | I | 3PE, PC1, SF4, CDL | 8 (best 0.79) |
| 8XNP | Respiratory complex Peripheral Arm of CI, close form B, focus-refined map of type IA, Wild type… | electron microscopy | I | 3PE, PC1, SF4, CDL | 8 (best 0.81) |
| 8XNQ | Respiratory complex Peripheral Arm of CI, open form A, focus-refined map of type IA, Wild type… | electron microscopy | I | 3PE, PC1, SF4, CDL | 8 (best 0.78) |
| 8XNR | Respiratory complex Peripheral Arm of CI, close form A, focus-refined map of type IB, Wild type… | electron microscopy | I | 3PE, PC1, SF4 | 8 (best 0.78) |
| 8XNS | Respiratory complex Peripheral Arm of CI, close form B, focus-refined map of type IB, Wild type… | electron microscopy | I | 3PE, SF4 | 8 (best 0.78) |
| 8XNT | Respiratory complex Peripheral Arm of CI, close form C, focus-refined map of type IB, Wild type… | electron microscopy | I | SF4 | 6 (best 0.77) |
| 8XNU | Respiratory complex Peripheral Arm of CI, open form A, focus-refined map of type IB, Wild type… | electron microscopy | I | 3PE, SF4 | 7 (best 0.77) |
| 8XNV | Respiratory complex Peripheral Arm of CI, close form A, focus-refined map of type II, Wild type… | electron microscopy | I | 3PE, SF4 | 7 (best 0.86) |
| 8XNW | Respiratory complex Peripheral Arm of CI, close form B, focus-refined map of type II, Wild type… | electron microscopy | I | 3PE, SF4 | 7 (best 0.87) |
| 8XNX | Respiratory complex Peripheral Arm of CI, open form A, focus-refined map of type II, Wild type… | electron microscopy | I | 3PE, SF4 | 8 (best 0.86) |
| 8XNY | Respiratory complex Peripheral Arm of CI, open form B, focus-refined map of type II, Wild type… | electron microscopy | I | SF4 | 6 (best 0.86) |
| 8XNZ | Respiratory complex Peripheral Arm of CI, close form A, focus-refined map of type I, PERK -/- mouse… | electron microscopy | I | 3PE, PC1, SF4, CDL | 9 (best 0.85) |
| Q8K3J1 | AlphaFold monomer V2.0 prediction for NADH dehydrogenase [ubiquinone] iron-sulfur protein 8… | predicted | A | — | 1 (best 0.45) |
Ligands
Experiment against prediction
- 8RGQ chain 9 against the predicted model Q8K3J1: TM-score 0.96, RMSD 1.13 Å
- 8IB9 chain I against the predicted model Q8K3J1: TM-score 0.95, RMSD 1.16 Å
- 8IB4 chain I against the predicted model Q8K3J1: TM-score 0.95, RMSD 1.16 Å
- 8IB5 chain I against the predicted model Q8K3J1: TM-score 0.95, RMSD 1.16 Å
- 8XNR chain I against the predicted model Q8K3J1: TM-score 0.95, RMSD 1.16 Å
- 8XNT chain I against the predicted model Q8K3J1: TM-score 0.95, RMSD 1.16 Å
- 8XNU chain I against the predicted model Q8K3J1: TM-score 0.95, RMSD 1.16 Å
- 8XNQ chain I against the predicted model Q8K3J1: TM-score 0.95, RMSD 1.16 Å
- 8XNO chain I against the predicted model Q8K3J1: TM-score 0.95, RMSD 1.16 Å
- 8XNP chain I against the predicted model Q8K3J1: TM-score 0.95, RMSD 1.16 Å
Elsewhere
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