UniProt Q9D6J6
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (Q9D6J6)
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (UniProt Q9D6J6), EC 1.6.5.3, 1.6.99.3: 24 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 26 pockets. Binding sites, druggability and…
- UniProt
- Q9D6J6
- Protein
- NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
- EC
- 1.6.5.3, 1.6.99.3, 7.1.1.2
- Experimental structures
- 24
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 26 · 9 records with a druggable one
Structures
25 records of Q9D6J6 in the MolNFT archive: 24 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6G2J | Mouse mitochondrial complex I in the active state | electron microscopy | E | FES | — |
| 6G2J | Mouse mitochondrial complex I in the active state | electron microscopy | E | FES | — |
| 6G72 | Mouse mitochondrial complex I in the deactive state | electron microscopy | E | FES | — |
| 6ZR2 | Cryo-EM structure of respiratory complex I in the active state from Mus musculus at 3.1 A | electron microscopy | E | FES | — |
| 6ZR2 | Cryo-EM structure of respiratory complex I in the active state from mus musculus at 3.1 a | electron microscopy | E | FES | — |
| 6ZTQ | Cryo-EM structure of respiratory complex I from mus musculus inhibited by piericidin a at 3.0 a | electron microscopy | E | FES | — |
| 7AK5 | Cryo-EM structure of respiratory complex I in the deactive state from Mus musculus at 3.2 A | electron microscopy | E | FES | — |
| 7AK5 | Cryo-EM structure of respiratory complex I in the deactive state from mus musculus at 3.2 a | electron microscopy | E | FES | — |
| 7AK6 | Cryo-EM structure of ND6-P25L mutant respiratory complex I from mus musculus at 3.8 a | electron microscopy | E | FES | — |
| 7B93 | Cryo-EM structure of mitochondrial complex I from Mus musculus inhibited by IACS-2858 at 3.0 A | electron microscopy | E | FES | — |
| 7B93 | Cryo-EM structure of mitochondrial complex I from mus musculus inhibited by iacs-2858 at 3.0 a | electron microscopy | E | FES | — |
| 8C2S | Cryo-EM structure NDUFS4 knockout complex I from Mus musculus heart (Class 1). | electron microscopy | E | FES | — |
| 8IAP | Respiratory complex Peripheral Arm of CI, focus-refined map of type I, Wild type mouse under… | electron microscopy | E | FES | 2 (best 0.80) |
| 8IB5 | Respiratory complex Peripheral Arm of CI, focus-refined map of type IA, Wild type mouse under cold… | electron microscopy | E | FES | 2 (best 0.79) |
| 8IBD | Respiratory complex CI:CIII2, type II, Wild type mouse under cold temperature | electron microscopy | E | FES | — |
| 8IBE | Respiratory complex Peripheral Arm of CI, focus-refined map of type II, Wild type mouse under cold… | electron microscopy | E | FES | 3 (best 0.79) |
| 8OM1 | Mitochondrial complex I from Mus musculus in the active state | electron microscopy | E | FES | 1 (best 0.80) |
| 8PW6 | C respirasome from murine liver | electron microscopy | 2 | FES | — |
| 8RGQ | Open Complex I from murine liver | electron microscopy | 2 | FES | — |
| 8RGR | Closed Complex I from murine liver | electron microscopy | 2 | FES | — |
| 8XNM | Respiratory complex Peripheral Arm of CI, close form B, focus-refined map of type I, Wild type… | electron microscopy | E | FES | 3 (best 0.79) |
| 8XNP | Respiratory complex Peripheral Arm of CI, close form B, focus-refined map of type IA, Wild type… | electron microscopy | E | FES | 4 (best 0.79) |
| 8XNT | Respiratory complex Peripheral Arm of CI, close form C, focus-refined map of type IB, Wild type… | electron microscopy | E | FES | 4 (best 0.79) |
| 8XNW | Respiratory complex Peripheral Arm of CI, close form B, focus-refined map of type II, Wild type… | electron microscopy | E | FES | 4 (best 0.77) |
| Q9D6J6 | AlphaFold monomer V2.0 prediction for NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial… | predicted | A | — | 3 (best 0.59) |
Ligands
- FES · Fe2/s2 (inorganic) cluster · in 24 records
Experiment against prediction
- 8RGR chain 2 against the predicted model Q9D6J6: TM-score 0.99, RMSD 0.69 Å
- 8OM1 chain E against the predicted model Q9D6J6: TM-score 0.98, RMSD 0.74 Å
- 8RGQ chain 2 against the predicted model Q9D6J6: TM-score 0.98, RMSD 0.71 Å
- 6ZR2 chain E against the predicted model Q9D6J6: TM-score 0.98, RMSD 0.72 Å
- 6ZR2 chain E against the predicted model Q9D6J6: TM-score 0.98, RMSD 0.72 Å
- 8PW6 chain 2 against the predicted model Q9D6J6: TM-score 0.98, RMSD 0.75 Å
- 6ZTQ chain E against the predicted model Q9D6J6: TM-score 0.98, RMSD 0.73 Å
- 7B93 chain E against the predicted model Q9D6J6: TM-score 0.98, RMSD 0.84 Å
- 7B93 chain E against the predicted model Q9D6J6: TM-score 0.98, RMSD 0.84 Å
- 8C2S chain E against the predicted model Q9D6J6: TM-score 0.98, RMSD 0.77 Å
Elsewhere
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