UniProt Q9CQC7
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 (Q9CQC7)
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 (UniProt Q9CQC7): 36 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 80 pockets. Binding sites, druggability and experiment against…
- UniProt
- Q9CQC7
- Protein
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4
- Experimental structures
- 36
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 80 · 28 records with a druggable one
Structures
37 records of Q9CQC7 in the MolNFT archive: 36 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6G2J | Mouse mitochondrial complex I in the active state | electron microscopy | m | — | 3 (best 0.88) |
| 6G2J | Mouse mitochondrial complex I in the active state | electron microscopy | m | — | — |
| 6G72 | Mouse mitochondrial complex I in the deactive state | electron microscopy | m | — | 3 (best 0.88) |
| 6G72 | Mouse mitochondrial complex I in the deactive state | electron microscopy | m | — | — |
| 6ZR2 | Cryo-EM structure of respiratory complex I in the active state from Mus musculus at 3.1 A | electron microscopy | m | — | 1 (best 0.88) |
| 6ZR2 | Cryo-EM structure of respiratory complex I in the active state from mus musculus at 3.1 a | electron microscopy | m | — | — |
| 6ZTQ | Cryo-EM structure of respiratory complex I from Mus musculus inhibited by piericidin A at 3.0 A | electron microscopy | m | — | 1 (best 0.87) |
| 6ZTQ | Cryo-EM structure of respiratory complex I from mus musculus inhibited by piericidin a at 3.0 a | electron microscopy | m | — | — |
| 7AK5 | Cryo-EM structure of respiratory complex I in the deactive state from Mus musculus at 3.2 A | electron microscopy | m | — | — |
| 7AK5 | Cryo-EM structure of respiratory complex I in the deactive state from mus musculus at 3.2 a | electron microscopy | m | — | — |
| 7AK6 | Cryo-EM structure of ND6-P25L mutant respiratory complex I from Mus musculus at 3.8 A | electron microscopy | m | — | 2 (best 0.87) |
| 7AK6 | Cryo-EM structure of ND6-P25L mutant respiratory complex I from mus musculus at 3.8 a | electron microscopy | m | — | — |
| 7B93 | Cryo-EM structure of mitochondrial complex I from Mus musculus inhibited by IACS-2858 at 3.0 A | electron microscopy | m | — | 2 (best 0.89) |
| 7B93 | Cryo-EM structure of mitochondrial complex I from mus musculus inhibited by iacs-2858 at 3.0 a | electron microscopy | m | — | — |
| 7PSA | The acetogenin-bound complex I of Mus musculus resolved to 3.4 angstroms | electron microscopy | m | — | 1 (best 0.88) |
| 8C2S | Cryo-EM structure NDUFS4 knockout complex I from Mus musculus heart (Class 1). | electron microscopy | m | — | 2 (best 0.88) |
| 8CA3 | Cryo-EM structure NDUFS4 knockout complex I from Mus musculus heart (Class 2). | electron microscopy | m | — | 4 (best 0.89) |
| 8CA5 | Cryo-EM structure NDUFS4 knockout complex I from Mus musculus heart (Class 3). | electron microscopy | m | — | 4 (best 0.88) |
| 8IAO | Respiratory complex CI:CIII2, type I, Wild type mouse under thermoneutral temperature | electron microscopy | m | 3PE | 3 (best 0.86) |
| 8IAQ | Respiratory complex Membrane domain of CI, focused map of type I, Wild type mouse under… | electron microscopy | m | 3PE | 4 (best 0.85) |
| 8IB4 | Respiratory complex CI:CIII2, type IA, Wild type mouse under cold temperature | electron microscopy | m | 3PE | 2 (best 0.87) |
| 8IB6 | Respiratory complex Membrane domain of CI, focus-refined of type IA, Wild type mouse under cold… | electron microscopy | m | 3PE | 4 (best 0.87) |
| 8IB9 | Respiratory complex CI:CIII2, type IB, Wild type mouse under cold temperature | electron microscopy | m | 3PE | 3 (best 0.86) |
| 8IBB | Respiratory complex Membrane domain of CI, focus-refined of type IB, Wild type mouse under cold… | electron microscopy | m | 3PE | 6 (best 0.86) |
| 8IBD | Respiratory complex CI:CIII2, type II, Wild type mouse under cold temperature | electron microscopy | m | 3PE | 3 (best 0.86) |
| 8IBF | Respiratory complex Membrane domain of CI, focus-refined of type II, Wild type mouse under cold… | electron microscopy | m | 3PE | 5 (best 0.86) |
| 8IC2 | Respiratory complex CI:CIII2, type I, PERK -/- mouse under cold temperature | electron microscopy | m | 3PE | 2 (best 0.86) |
| 8IC4 | Respiratory complex Membrane domain of CI, focus-refined of type I, PERK -/- mouse under cold… | electron microscopy | m | 3PE | 5 (best 0.86) |
| 8OLT | Mitochondrial complex I from Mus musculus in the active state bound with piericidin A | electron microscopy | m | — | 2 (best 0.89) |
| 8OM1 | Mitochondrial complex I from Mus musculus in the active state | electron microscopy | m | PC1 | 3 (best 0.88) |
| 8PW5 | CS respirasome from murine liver | electron microscopy | m1 | CDL, 3PE | 1 (best 0.88) |
| 8PW6 | C respirasome from murine liver | electron microscopy | m1 | 3PE, CDL | 1 (best 0.88) |
| 8PW7 | A respirasome from murine liver | electron microscopy | m1 | CDL, 3PE | 1 (best 0.89) |
| 8RGP | Closed Complex I from murine brain | electron microscopy | m | 3PE, CDL | 4 (best 0.90) |
| 8RGQ | Open Complex I from murine liver | electron microscopy | m | 3PE, CDL | 5 (best 0.88) |
| 8RGR | Closed Complex I from murine liver | electron microscopy | m | 3PE, CDL | 3 (best 0.88) |
| Q9CQC7 | AlphaFold monomer V2.0 prediction for NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4… | predicted | A | — | — |
Ligands
Experiment against prediction
- 8RGQ chain m against the predicted model Q9CQC7: TM-score 0.94, RMSD 1.08 Å
- 8RGR chain m against the predicted model Q9CQC7: TM-score 0.94, RMSD 1.08 Å
- 8OLT chain m against the predicted model Q9CQC7: TM-score 0.94, RMSD 1.06 Å
- 8PW7 chain m1 against the predicted model Q9CQC7: TM-score 0.94, RMSD 1.08 Å
- 8PW6 chain m1 against the predicted model Q9CQC7: TM-score 0.94, RMSD 1.09 Å
- 8OM1 chain m against the predicted model Q9CQC7: TM-score 0.94, RMSD 1.09 Å
- 8IB9 chain m against the predicted model Q9CQC7: TM-score 0.94, RMSD 1.12 Å
- 8IBB chain m against the predicted model Q9CQC7: TM-score 0.94, RMSD 1.12 Å
- 8IC2 chain m against the predicted model Q9CQC7: TM-score 0.94, RMSD 1.12 Å
- 8IC4 chain m against the predicted model Q9CQC7: TM-score 0.94, RMSD 1.12 Å
Elsewhere
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