UniProt Q9CQZ5

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 (Q9CQZ5)

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 (UniProt Q9CQZ5): 53 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 143 pockets. Binding sites, druggability and experiment against…

UniProt: Q9CQZ5
Protein: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6
Experimental structures: 53
Predicted models: 1
Ligands: 2
Pockets: 143 · 46 records with a druggable one

Structures

54 records of Q9CQZ5 in the MolNFT archive: 53 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
6G2J	Mouse mitochondrial complex I in the active state	electron microscopy	W	EHZ	1 (best 0.87)
6G2J	Mouse mitochondrial complex I in the active state	electron microscopy	W	EHZ	—
6G72	Mouse mitochondrial complex I in the deactive state	electron microscopy	W	EHZ	2 (best 0.89)
6G72	Mouse mitochondrial complex I in the deactive state	electron microscopy	W	EHZ	—
6ZR2	Cryo-EM structure of respiratory complex I in the active state from Mus musculus at 3.1 A	electron microscopy	W	EHZ	3 (best 0.87)
6ZR2	Cryo-EM structure of respiratory complex I in the active state from mus musculus at 3.1 a	electron microscopy	W	EHZ	—
6ZTQ	Cryo-EM structure of respiratory complex I from Mus musculus inhibited by piericidin A at 3.0 A	electron microscopy	W	EHZ	1 (best 0.87)
6ZTQ	Cryo-EM structure of respiratory complex I from mus musculus inhibited by piericidin a at 3.0 a	electron microscopy	W	EHZ	—
7AK5	Cryo-EM structure of respiratory complex I in the deactive state from Mus musculus at 3.2 A	electron microscopy	W	EHZ	—
7AK5	Cryo-EM structure of respiratory complex I in the deactive state from mus musculus at 3.2 a	electron microscopy	W	EHZ	—
7AK6	Cryo-EM structure of ND6-P25L mutant respiratory complex I from Mus musculus at 3.8 A	electron microscopy	W	EHZ	2 (best 0.83)
7AK6	Cryo-EM structure of ND6-P25L mutant respiratory complex I from mus musculus at 3.8 a	electron microscopy	W	EHZ	—
7B93	Cryo-EM structure of mitochondrial complex I from Mus musculus inhibited by IACS-2858 at 3.0 A	electron microscopy	W	EHZ	3 (best 0.87)
7B93	Cryo-EM structure of mitochondrial complex I from mus musculus inhibited by iacs-2858 at 3.0 a	electron microscopy	W	EHZ	—
7PSA	The acetogenin-bound complex I of Mus musculus resolved to 3.4 angstroms	electron microscopy	W	EHZ	2 (best 0.86)
8C2S	Cryo-EM structure NDUFS4 knockout complex I from Mus musculus heart (Class 1).	electron microscopy	W	EHZ	1 (best 0.82)
8CA3	Cryo-EM structure NDUFS4 knockout complex I from Mus musculus heart (Class 2).	electron microscopy	W	EHZ	3 (best 0.88)
8CA5	Cryo-EM structure NDUFS4 knockout complex I from Mus musculus heart (Class 3).	electron microscopy	W	EHZ	2 (best 0.88)
8IAO	Respiratory complex CI:CIII2, type I, Wild type mouse under thermoneutral temperature	electron microscopy	W	EHZ	3 (best 0.86)
8IAP	Respiratory complex Peripheral Arm of CI, focus-refined map of type I, Wild type mouse under…	electron microscopy	W	EHZ	6 (best 0.86)
8IB4	Respiratory complex CI:CIII2, type IA, Wild type mouse under cold temperature	electron microscopy	W	EHZ	2 (best 0.84)
8IB5	Respiratory complex Peripheral Arm of CI, focus-refined map of type IA, Wild type mouse under cold…	electron microscopy	W	EHZ	4 (best 0.84)
8IB9	Respiratory complex CI:CIII2, type IB, Wild type mouse under cold temperature	electron microscopy	W	EHZ	1 (best 0.87)
8IBA	Respiratory complex Peripheral Arm of CI, focus-refined map of type IB, Wild type mouse under cold…	electron microscopy	W	EHZ	4 (best 0.84)
8IBD	Respiratory complex CI:CIII2, type II, Wild type mouse under cold temperature	electron microscopy	W	EHZ	2 (best 0.86)
8IBE	Respiratory complex Peripheral Arm of CI, focus-refined map of type II, Wild type mouse under cold…	electron microscopy	W	EHZ	4 (best 0.87)
8IC2	Respiratory complex CI:CIII2, type I, PERK -/- mouse under cold temperature	electron microscopy	W	EHZ	1 (best 0.86)
8IC3	Respiratory complex Peripheral Arm of CI, focus-refined map of type I, PERK -/- mouse under cold…	electron microscopy	W	EHZ	4 (best 0.87)
8OLT	Mitochondrial complex I from Mus musculus in the active state bound with piericidin A	electron microscopy	W	EHZ	2 (best 0.86)
8OM1	Mitochondrial complex I from Mus musculus in the active state	electron microscopy	W	EHZ	3 (best 0.89)
8PW5	CS respirasome from murine liver	electron microscopy	W1	ZMP	2 (best 0.90)
8PW6	C respirasome from murine liver	electron microscopy	W1	ZMP	4 (best 0.90)
8PW7	A respirasome from murine liver	electron microscopy	W1	ZMP	3 (best 0.88)
8RGP	Closed Complex I from murine brain	electron microscopy	W	ZMP	4 (best 0.89)
8RGQ	Open Complex I from murine liver	electron microscopy	W	ZMP	3 (best 0.90)
8RGR	Closed Complex I from murine liver	electron microscopy	W	ZMP	3 (best 0.87)
8RGT	Open Complex I from murine brain	electron microscopy	W	ZMP	3 (best 0.89)
8XNL	Respiratory complex Peripheral Arm of CI, close form A, focus-refined map of type I, Wild type…	electron microscopy	W	EHZ	6 (best 0.88)
8XNM	Respiratory complex Peripheral Arm of CI, close form B, focus-refined map of type I, Wild type…	electron microscopy	W	EHZ	6 (best 0.88)
8XNN	Respiratory complex Peripheral Arm of CI, open form A, focus-refined map of type I, Wild type mouse…	electron microscopy	W	EHZ	4 (best 0.87)
8XNO	Respiratory complex Peripheral Arm of CI, close form A, focus-refined map of type IA, Wild type…	electron microscopy	W	EHZ	2 (best 0.87)
8XNP	Respiratory complex Peripheral Arm of CI, close form B, focus-refined map of type IA, Wild type…	electron microscopy	W	EHZ	4 (best 0.88)
8XNQ	Respiratory complex Peripheral Arm of CI, open form A, focus-refined map of type IA, Wild type…	electron microscopy	W	EHZ	5 (best 0.88)
8XNR	Respiratory complex Peripheral Arm of CI, close form A, focus-refined map of type IB, Wild type…	electron microscopy	W	EHZ	3 (best 0.89)
8XNS	Respiratory complex Peripheral Arm of CI, close form B, focus-refined map of type IB, Wild type…	electron microscopy	W	EHZ	4 (best 0.88)
8XNT	Respiratory complex Peripheral Arm of CI, close form C, focus-refined map of type IB, Wild type…	electron microscopy	W	EHZ	3 (best 0.84)
8XNU	Respiratory complex Peripheral Arm of CI, open form A, focus-refined map of type IB, Wild type…	electron microscopy	W	EHZ	4 (best 0.84)
8XNV	Respiratory complex Peripheral Arm of CI, close form A, focus-refined map of type II, Wild type…	electron microscopy	W	EHZ	5 (best 0.88)
8XNW	Respiratory complex Peripheral Arm of CI, close form B, focus-refined map of type II, Wild type…	electron microscopy	W	EHZ	4 (best 0.87)
8XNX	Respiratory complex Peripheral Arm of CI, open form A, focus-refined map of type II, Wild type…	electron microscopy	W	EHZ	3 (best 0.87)
8XNY	Respiratory complex Peripheral Arm of CI, open form B, focus-refined map of type II, Wild type…	electron microscopy	W	EHZ	4 (best 0.86)
8XNZ	Respiratory complex Peripheral Arm of CI, close form A, focus-refined map of type I, PERK -/- mouse…	electron microscopy	W	EHZ	3 (best 0.87)
8XO0	Respiratory complex Peripheral Arm of CI, close form B, focus-refined map of type I, PERK -/- mouse…	electron microscopy	W	—	4 (best 0.89)
Q9CQZ5	AlphaFold monomer V2.0 prediction for NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6…	predicted	A	—	1 (best 0.72)

Ligands

EHZ · ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate · in 45 records
ZMP · S-[2-({N-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy) butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate · in 7 records

Experiment against prediction

8RGT chain W against the predicted model Q9CQZ5: TM-score 0.98, RMSD 0.65 Å
8PW5 chain W1 against the predicted model Q9CQZ5: TM-score 0.98, RMSD 0.67 Å
8RGQ chain W against the predicted model Q9CQZ5: TM-score 0.98, RMSD 0.67 Å
8PW7 chain W1 against the predicted model Q9CQZ5: TM-score 0.97, RMSD 0.68 Å
8RGR chain W against the predicted model Q9CQZ5: TM-score 0.97, RMSD 0.69 Å
7B93 chain W against the predicted model Q9CQZ5: TM-score 0.97, RMSD 0.67 Å
7B93 chain W against the predicted model Q9CQZ5: TM-score 0.97, RMSD 0.67 Å
8PW6 chain W1 against the predicted model Q9CQZ5: TM-score 0.97, RMSD 0.69 Å
8OM1 chain W against the predicted model Q9CQZ5: TM-score 0.97, RMSD 0.70 Å
8OLT chain W against the predicted model Q9CQZ5: TM-score 0.97, RMSD 0.69 Å

Elsewhere

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