UniProt P52503
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial (P52503)
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial (UniProt P52503): 15 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 20 pockets. Binding sites, druggability and experiment against…
- UniProt
- P52503
- Protein
- NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial
- Experimental structures
- 15
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 20 · 7 records with a druggable one
Structures
16 records of P52503 in the MolNFT archive: 15 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6G2J | Mouse mitochondrial complex I in the active state | electron microscopy | R | ZN | 2 (best 0.82) |
| 6G2J | Mouse mitochondrial complex I in the active state | electron microscopy | R | ZN | — |
| 6G72 | Mouse mitochondrial complex I in the deactive state | electron microscopy | R | ZN | — |
| 6ZR2 | Cryo-EM structure of respiratory complex I in the active state from mus musculus at 3.1 a | electron microscopy | R | ZN | — |
| 6ZTQ | Cryo-EM structure of respiratory complex I from mus musculus inhibited by piericidin a at 3.0 a | electron microscopy | R | ZN | — |
| 7AK5 | Cryo-EM structure of respiratory complex I in the deactive state from Mus musculus at 3.2 A | electron microscopy | R | ZN | — |
| 7AK5 | Cryo-EM structure of respiratory complex I in the deactive state from mus musculus at 3.2 a | electron microscopy | R | ZN | — |
| 7AK6 | Cryo-EM structure of ND6-P25L mutant respiratory complex I from mus musculus at 3.8 a | electron microscopy | R | ZN | — |
| 7B93 | Cryo-EM structure of mitochondrial complex I from mus musculus inhibited by iacs-2858 at 3.0 a | electron microscopy | R | ZN | — |
| 8IAP | Respiratory complex Peripheral Arm of CI, focus-refined map of type I, Wild type mouse under… | electron microscopy | R | ZN | 4 (best 0.78) |
| 8IBD | Respiratory complex CI:CIII2, type II, Wild type mouse under cold temperature | electron microscopy | R | ZN | 1 (best 0.84) |
| 8IBE | Respiratory complex Peripheral Arm of CI, focus-refined map of type II, Wild type mouse under cold… | electron microscopy | R | ZN | 5 (best 0.83) |
| 8PW6 | C respirasome from murine liver | electron microscopy | 7 | ZN | 1 (best 0.83) |
| 8RGR | Closed Complex I from murine liver | electron microscopy | 7 | ZN | 2 (best 0.84) |
| 8XNP | Respiratory complex Peripheral Arm of CI, close form B, focus-refined map of type IA, Wild type… | electron microscopy | R | ZN | 4 (best 0.81) |
| P52503 | AlphaFold monomer V2.0 prediction for NADH dehydrogenase [ubiquinone] iron-sulfur protein 6… | predicted | A | — | 1 (best 0.30) |
Ligands
- ZN · Zinc ion · in 15 records
Experiment against prediction
- 8RGR chain 7 against the predicted model P52503: TM-score 0.98, RMSD 0.54 Å
- 8PW6 chain 7 against the predicted model P52503: TM-score 0.97, RMSD 0.65 Å
- 8IAP chain R against the predicted model P52503: TM-score 0.97, RMSD 0.60 Å
- 7B93 chain R against the predicted model P52503: TM-score 0.96, RMSD 0.93 Å
- 7AK5 chain R against the predicted model P52503: TM-score 0.96, RMSD 0.71 Å
- 7AK5 chain R against the predicted model P52503: TM-score 0.96, RMSD 0.71 Å
- 6ZTQ chain R against the predicted model P52503: TM-score 0.96, RMSD 0.78 Å
- 7AK6 chain R against the predicted model P52503: TM-score 0.96, RMSD 0.77 Å
- 6ZR2 chain R against the predicted model P52503: TM-score 0.96, RMSD 0.79 Å
- 6G2J chain R against the predicted model P52503: TM-score 0.95, RMSD 0.84 Å
Elsewhere
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