UniProt P03888
NADH-ubiquinone oxidoreductase chain 1 (P03888)
NADH-ubiquinone oxidoreductase chain 1 (UniProt P03888), EC 1.6.5.3, 7.1.1.2: 63 experimental structures and 1 predicted model on GenesisL1, 8 ligands bound, 220 pockets. Binding sites, druggability and experiment against…
- UniProt
- P03888
- Protein
- NADH-ubiquinone oxidoreductase chain 1
- EC
- 1.6.5.3, 7.1.1.2
- Experimental structures
- 63
- Predicted models
- 1
- Ligands
- 8
- Pockets
- 220 · 47 records with a druggable one
Structures
64 records of P03888 in the MolNFT archive: 63 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6G2J | Mouse mitochondrial complex I in the active state | electron microscopy | H | 3PE, PC1, CDL | 4 (best 0.88) |
| 6G2J | Mouse mitochondrial complex I in the active state | electron microscopy | H | 3PE, PC1, CDL | — |
| 6G72 | Mouse mitochondrial complex I in the deactive state | electron microscopy | H | — | 3 (best 0.84) |
| 6G72 | Mouse mitochondrial complex I in the deactive state | electron microscopy | H | — | — |
| 6ZR2 | Cryo-EM structure of respiratory complex I in the active state from Mus musculus at 3.1 A | electron microscopy | H | PC1, 3PE, CDL | 5 (best 0.90) |
| 6ZR2 | Cryo-EM structure of respiratory complex I in the active state from mus musculus at 3.1 a | electron microscopy | H | PC1, 3PE, CDL | — |
| 6ZTQ | Cryo-EM structure of respiratory complex I from Mus musculus inhibited by piericidin A at 3.0 A | electron microscopy | H | PC1, 3PE, CDL | 5 (best 0.89) |
| 6ZTQ | Cryo-EM structure of respiratory complex I from mus musculus inhibited by piericidin a at 3.0 a | electron microscopy | H | PC1, 3PE, CDL | — |
| 7AK5 | Cryo-EM structure of respiratory complex I in the deactive state from Mus musculus at 3.2 A | electron microscopy | H | PC1, 3PE, CDL | — |
| 7AK5 | Cryo-EM structure of respiratory complex I in the deactive state from mus musculus at 3.2 a | electron microscopy | H | PC1, 3PE, CDL | — |
| 7AK6 | Cryo-EM structure of ND6-P25L mutant respiratory complex I from Mus musculus at 3.8 A | electron microscopy | H | PC1, 3PE | 4 (best 0.88) |
| 7AK6 | Cryo-EM structure of ND6-P25L mutant respiratory complex I from mus musculus at 3.8 a | electron microscopy | H | PC1, 3PE | — |
| 7B93 | Cryo-EM structure of mitochondrial complex I from Mus musculus inhibited by IACS-2858 at 3.0 A | electron microscopy | H | PC1, 3PE, T2Q, CDL | 4 (best 0.89) |
| 7B93 | Cryo-EM structure of mitochondrial complex I from mus musculus inhibited by iacs-2858 at 3.0 a | electron microscopy | H | PC1, 3PE, T2Q, CDL | — |
| 7LFI | MODEL OF MHC CLASS Ib H2-M3 WITH MOUSE ND1 N-TERMINAL HEPTAPEPTIDE REFINED AT 1.70 ANGSTROMS… | x-ray diffraction | C, F | — | 2 (best 0.41) |
| 7LFI | Model of MHC class ib H2-M3 with mouse ND1 N-terminal heptapeptide refined at 1.70 ångströms… | x-ray diffraction | C, F | — | — |
| 7LFJ | MODEL OF MHC CLASS Ib H2-M3 WITH MOUSE ND1 N-TERMINAL HEPTAPEPTIDE, ALA MUTANT, REFINED AT 1.70… | x-ray diffraction | C, F | — | 1 (best 0.76) |
| 7LFJ | Model of MHC class ib H2-M3 with mouse ND1 N-terminal heptapeptide, ala mutant, refined at 1.70… | x-ray diffraction | C, F | — | — |
| 7LFK | MODEL OF MHC CLASS Ib H2-M3 WITH MOUSE ND1 N-TERMINAL HEPTAPEPTIDE, THR MUTANT, REFINED AT 1.60… | x-ray diffraction | C, F | — | 1 (best 0.40) |
| 7LFK | Model of MHC class ib H2-M3 with mouse ND1 N-terminal heptapeptide, thr mutant, refined at 1.60… | x-ray diffraction | C, F | — | — |
| 7LFL | MODEL OF MHC CLASS Ib H2-M3 WITH MOUSE ND1 N-TERMINAL HEPTAPEPTIDE, VAL MUTANT, MONOCLINIC CELL… | x-ray diffraction | C | — | — |
| 7LFL | Model of MHC class ib H2-M3 with mouse ND1 N-terminal heptapeptide, val mutant, monoclinic cell… | x-ray diffraction | C | — | — |
| 7LFM | MODEL OF MHC CLASS Ib H2-M3 WITH MOUSE ND1 N-TERMINAL HEPTAPEPTIDE, VAL MUTANT, TRICLINIC CELL… | x-ray diffraction | C, F | — | 1 (best 0.42) |
| 7LFM | Model of MHC class ib H2-M3 with mouse ND1 N-terminal heptapeptide, val mutant, triclinic cell… | x-ray diffraction | C, F | — | — |
| 7PSA | The acetogenin-bound complex I of Mus musculus resolved to 3.4 angstroms | electron microscopy | H | PC1, 3PE, 88I, CDL | 5 (best 0.88) |
| 8C2S | Cryo-EM structure NDUFS4 knockout complex I from Mus musculus heart (Class 1). | electron microscopy | H | PC1, 3PE | 4 (best 0.89) |
| 8CA3 | Cryo-EM structure NDUFS4 knockout complex I from Mus musculus heart (Class 2). | electron microscopy | H | PC1, UQ9, 3PE | 5 (best 0.90) |
| 8CA5 | Cryo-EM structure NDUFS4 knockout complex I from Mus musculus heart (Class 3). | electron microscopy | H | PC1, 3PE, UQ9 | 5 (best 0.89) |
| 8IAO | Respiratory complex CI:CIII2, type I, Wild type mouse under thermoneutral temperature | electron microscopy | H | 3PE, UQ9, PC1, CDL | 4 (best 0.90) |
| 8IAP | Respiratory complex Peripheral Arm of CI, focus-refined map of type I, Wild type mouse under… | electron microscopy | H | 3PE, UQ9, PC1, CDL | 5 (best 0.86) |
| 8IB4 | Respiratory complex CI:CIII2, type IA, Wild type mouse under cold temperature | electron microscopy | H | 3PE, PC1, UQ9, CDL | 3 (best 0.90) |
| 8IB5 | Respiratory complex Peripheral Arm of CI, focus-refined map of type IA, Wild type mouse under cold… | electron microscopy | H | 3PE, PC1, UQ9, CDL | 7 (best 0.87) |
| 8IB9 | Respiratory complex CI:CIII2, type IB, Wild type mouse under cold temperature | electron microscopy | H | PC1, UQ9, 3PE, CDL | 3 (best 0.90) |
| 8IBA | Respiratory complex Peripheral Arm of CI, focus-refined map of type IB, Wild type mouse under cold… | electron microscopy | H | 3PE, PC1, UQ9, CDL | 5 (best 0.87) |
| 8IBD | Respiratory complex CI:CIII2, type II, Wild type mouse under cold temperature | electron microscopy | H | 3PE, UQ1, PC1, UQ9, CDL | 4 (best 0.90) |
| 8IBE | Respiratory complex Peripheral Arm of CI, focus-refined map of type II, Wild type mouse under cold… | electron microscopy | H | 3PE, UQ1, PC1, UQ9, CDL | 7 (best 0.87) |
| 8IC2 | Respiratory complex CI:CIII2, type I, PERK -/- mouse under cold temperature | electron microscopy | H | UQ1, PC1, UQ9, 3PE, CDL | 3 (best 0.89) |
| 8IC3 | Respiratory complex Peripheral Arm of CI, focus-refined map of type I, PERK -/- mouse under cold… | electron microscopy | H | UQ1, PC1, UQ9, 3PE, CDL | 6 (best 0.89) |
| 8OLT | Mitochondrial complex I from Mus musculus in the active state bound with piericidin A | electron microscopy | H | PC1, CDL, 3PE | 4 (best 0.90) |
| 8OM1 | Mitochondrial complex I from Mus musculus in the active state | electron microscopy | H | PC1, CDL, 3PE | 4 (best 0.90) |
| 8PW5 | CS respirasome from murine liver | electron microscopy | H1 | 3PE, PC1, CDL | 3 (best 0.89) |
| 8PW6 | C respirasome from murine liver | electron microscopy | H1 | 3PE, PC1, CDL | 4 (best 0.89) |
| 8PW7 | A respirasome from murine liver | electron microscopy | H1 | 3PE, PC1, CDL | 3 (best 0.89) |
| 8RGP | Closed Complex I from murine brain | electron microscopy | H | 3PE, PC1, UQ, CDL | 5 (best 0.89) |
| 8RGQ | Open Complex I from murine liver | electron microscopy | H | 3PE, PC1, CDL | 3 (best 0.91) |
| 8RGR | Closed Complex I from murine liver | electron microscopy | H | 3PE, PC1, UQ, CDL | 4 (best 0.89) |
| 8RGT | Open Complex I from murine brain | electron microscopy | H | 3PE, PC1, CDL | 4 (best 0.88) |
| 8XNL | Respiratory complex Peripheral Arm of CI, close form A, focus-refined map of type I, Wild type… | electron microscopy | H | 3PE, UQ9, PC1, CDL | 4 (best 0.88) |
| 8XNM | Respiratory complex Peripheral Arm of CI, close form B, focus-refined map of type I, Wild type… | electron microscopy | H | 3PE, PC1, CDL | 5 (best 0.89) |
| 8XNN | Respiratory complex Peripheral Arm of CI, open form A, focus-refined map of type I, Wild type mouse… | electron microscopy | H | 3PE, UQ9, PC1, CDL | 4 (best 0.90) |
| 8XNO | Respiratory complex Peripheral Arm of CI, close form A, focus-refined map of type IA, Wild type… | electron microscopy | H | 3PE, PC1, UQ9, CDL | 4 (best 0.89) |
| 8XNP | Respiratory complex Peripheral Arm of CI, close form B, focus-refined map of type IA, Wild type… | electron microscopy | H | UQ9, PC1, 3PE, CDL | 6 (best 0.89) |
| 8XNQ | Respiratory complex Peripheral Arm of CI, open form A, focus-refined map of type IA, Wild type… | electron microscopy | H | 3PE, PC1, UQ9, CDL | 5 (best 0.88) |
| 8XNR | Respiratory complex Peripheral Arm of CI, close form A, focus-refined map of type IB, Wild type… | electron microscopy | H | 3PE, PC1, UQ9 | 5 (best 0.89) |
| 8XNS | Respiratory complex Peripheral Arm of CI, close form B, focus-refined map of type IB, Wild type… | electron microscopy | H | PC1, UQ9, 3PE | 7 (best 0.89) |
| 8XNT | Respiratory complex Peripheral Arm of CI, close form C, focus-refined map of type IB, Wild type… | electron microscopy | H | PC1, 3PE | 5 (best 0.86) |
| 8XNU | Respiratory complex Peripheral Arm of CI, open form A, focus-refined map of type IB, Wild type… | electron microscopy | H | 3PE, UQ9 | 5 (best 0.88) |
| 8XNV | Respiratory complex Peripheral Arm of CI, close form A, focus-refined map of type II, Wild type… | electron microscopy | H | 3PE, PC1, UQ9, CDL | 8 (best 0.88) |
| 8XNW | Respiratory complex Peripheral Arm of CI, close form B, focus-refined map of type II, Wild type… | electron microscopy | H | PC1, UQ9, 3PE, CDL | 6 (best 0.87) |
| 8XNX | Respiratory complex Peripheral Arm of CI, open form A, focus-refined map of type II, Wild type… | electron microscopy | H | 3PE, PC1, UQ9, CDL | 5 (best 0.89) |
4 records more on the page itself.
Ligands
- 3PE · 1,2-diacyl-sn-glycero-3-phosphoethanolamine · in 51 records
- PC1 · 1,2-diacyl-sn-glycero-3-phosphocholine · in 50 records
- CDL · Cardiolipin · in 41 records
- UQ9 · Ubiquinone-9 · in 24 records
- UQ1 · Ubiquinone-1 · in 4 records
- T2Q · 1-[[3-(4-methylsulfonylpiperidin-1-yl)phenyl]methyl]-5-[3-[4-(trifluoromethyloxy)phenyl]-1,2,4-oxadiazol-5-yl]pyridin-2-one · in 2 records
- UQ · Coenzyme Q10, (2Z,6E,10Z,14E,18E,22E,26Z)-isomer · in 2 records
- 88I · (3~{S},5~{S})-5-methyl-3-[(13~{R})-13-oxidanyl-13-[(2~{R},5~{R})-5-[(2~{R},5~{R})-5-[(1~{R})-1-oxidanylundecyl]oxolan-2-yl]oxolan-2-yl]tridecyl]oxolan-2-one · in 1 record
Experiment against prediction
- 8CA3 chain H against the predicted model P03888: TM-score 0.99, RMSD 0.52 Å
- 8CA5 chain H against the predicted model P03888: TM-score 0.99, RMSD 0.53 Å
- 8OM1 chain H against the predicted model P03888: TM-score 0.99, RMSD 0.55 Å
- 8OLT chain H against the predicted model P03888: TM-score 0.99, RMSD 0.55 Å
- 8C2S chain H against the predicted model P03888: TM-score 0.99, RMSD 0.56 Å
- 7B93 chain H against the predicted model P03888: TM-score 0.99, RMSD 0.59 Å
- 7B93 chain H against the predicted model P03888: TM-score 0.99, RMSD 0.59 Å
- 8RGP chain H against the predicted model P03888: TM-score 0.99, RMSD 0.60 Å
- 6ZR2 chain H against the predicted model P03888: TM-score 0.99, RMSD 0.61 Å
- 6ZR2 chain H against the predicted model P03888: TM-score 0.99, RMSD 0.61 Å
Elsewhere
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