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Ligand · UQ

UQ · Coenzyme Q10, (2Z,6E,10Z,14E,18E,22E,26Z)-isomer

UQ, Coenzyme Q10, (2Z,6E,10Z,14E,18E,22E,26Z)-isomer (C59 H90 O4, 863.4 g/mol), in the MolNFT structures on GenesisL1: bound in 35 records (29 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and…

Component
UQ
Formula
C59 H90 O4
Class
ligand
Structures
35
PDB entries
29

Binding sites

UQ in 35 structures; the first of them:

  • 7V2D · Deactive state complex I from Q10 dataset · UQ s401 · binds TRP63, VAL92, LEU17, ILE11, LEU14, LEU15, ALA18, THR21 and 10 more
  • 7V2E · Active state complex I from Q10-NADH dataset · UQ J402 · binds ASN215, TYR216, SER219, TRP222, PHE223, TRP313, TRP23
  • 7V2F · Deactive state complex I from Q10-NADH dataset · UQ s403 · binds TRP63, VAL92, ILE11, LEU14, LEU15, ALA18, THR21, ARG25 and 9 more
  • 7V2K · Deactive state complex I from DQ-NADH dataset · UQ s403 · binds TRP63, VAL92, LEU15, ALA18, THR21, ARG25, PRO48, ASP51 and 7 more
  • 7V2R · Active state complex I from Q1-NADH dataset · UQ C304 · binds TRP63, ASP87, VAL92, ARG94, MET197, ILE11, LEU14, LEU15 and 12 more
  • 7V3M · Deactive state complex I from rote -NADH dataset · UQ s401 · binds TRP63, LEU14, LEU15, ALA18, THR21, ARG25, PRO48, ASP51 and 5 more
  • 7VBP · Membrane arm of deactive state CI from DQ-NADH dataset · UQ s402 · binds LEU14, LEU15, ALA18, THR21, ARG25, PRO48, ASP51, ALA52 and 4 more
  • 7VYE · Membrane arm of deactive state CI from Q10-NADH dataset · UQ s403 · binds ILE11, LEU14, LEU15, ALA18, THR21, ARG25, PRO48, ASP51 and 7 more
  • 7VYF · Matrix arm of active state CI from Rote dataset · UQ J403 · binds SER219, TRP222, PHE223, TRP313
  • 7W0H · Deactive state CI from Q10 dataset, Subclass 2 · UQ s401 · binds TRP63, VAL92, LEU17, ILE11, LEU14, LEU15, ALA18, THR21 and 11 more
  • 7W1O · Deactive state CI from Q10-NADH dataset, Subclass 1 · UQ s401 · binds TRP63, VAL92, ILE11, LEU14, LEU15, VAL17, ALA18, THR21 and 9 more
  • 7W20 · Active state CI from Rote -NADH dataset, Subclass 3 · UQ J402 · binds ASN215, TYR216, SER219, TRP222, TRP313, TRP23
  • 7W2K · Deactive state CI from Rote -NADH dataset, Subclass 1 · UQ s402 · binds TRP63, VAL92, ILE11, LEU14, LEU15, VAL17, ALA18, THR21 and 9 more
  • 7W2R · Active state CI from DQ-NADH dataset, Subclass 1 · UQ J402 · binds ARG212, ASN215, SER219, TRP222, PHE223, TRP313
  • 7W35 · Deactive state CI from DQ-NADH dataset, Subclass 3 · UQ s401 · binds TRP63, VAL92, LEU14, LEU15, ALA18, THR21, GLU24, ARG25 and 10 more
  • 7W4G · Active state CI from Q1-NADH dataset, Subclass 5 · UQ J402 · binds ARG212, ASN215, TYR216, SER219, TRP222, TRP313
  • 7W4J · Deactive state CI from Q1-NADH dataset, Subclass 1 · UQ s402 · binds TRP63, VAL92, LEU15, ALA18, THR21, ARG25, PRO48, ASP51 and 5 more
  • 7W4N · Deactive state CI from Q1-NADH dataset, Subclass 5 · UQ s401 · binds TRP63, VAL92, GLN99, LEU17, LEU14, LEU15, ALA18, THR21 and 10 more
  • 8RGR · Closed Complex I from murine liver · UQ D501 · binds TRP56, THR59, PHE60, GLY61, LEU62, ALA63, ALA66, MET69 and 36 more
  • 7V2C · Active state complex I from Q10 dataset · UQ J402 · binds TYR216, SER219, TRP313
  • 7V2D · Deactive state complex I from Q10 dataset · UQ s401 · binds TRP63, VAL92, LEU14, LEU15, ALA18, THR21, ARG25, PRO48 and 6 more
  • 7V2E · Active state complex I from Q10-NADH dataset · UQ J402 · binds SER219, TRP222, TRP313
  • 7V2F · Deactive state complex I from Q10-NADH dataset · UQ s403 · binds TRP63, LEU14, LEU15, ALA18, THR21, ARG25, ASP51, ALA52 and 5 more
  • 7V2H · Active state complex I from dq-NADH dataset · UQ J402 · binds SER219, TRP222, TRP313
  • 7V2K · Deactive state complex I from dq-NADH dataset · UQ s403 · binds TRP63, VAL92, LEU15, ALA18, THR21, ARG25, ASP51, ALA52 and 5 more
  • 7V2R · Active state complex I from Q1-NADH dataset · UQ C304 · binds TRP63, VAL92, ARG94, MET197, LEU14, LEU15, ALA18, ARG25 and 6 more
  • 7V30 · Deactive state complex I from Q1-NADH dataset · UQ s403 · binds TRP63, VAL92, LEU15, ALA18, THR21, ARG25, PRO48, ASP51 and 5 more
  • 7V31 · Active state complex I from rotenone dataset · UQ J402 · binds SER219, TRP222, PHE223, TRP313
  • 7V32 · Deactive state complex I from rotenone dataset · UQ s401 · binds TRP63, VAL92, ILE11, LEU14, LEU15, ALA18, THR21, ARG25 and 7 more
  • 7V33 · Active state complex I from rotenone-NADH dataset · UQ J402 · binds ASN215, SER219, TRP222, TRP313

Residues it binds most

LEU 34, ALA 34, PHE 38, ARG 38, TRP 42, MET 34, ASP 34, THR 33, VAL 25, PRO 24 (residue and the binding sites it lines).

Found with

  • CDL · Cardiolipin
  • 8Q1 · S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy) butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate
  • PEE · 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine
  • PLX · (9R,11S)-9-({[(1S)-1-hydroxyhexadecyl]oxy}methyl)-2,2-dimethyl-5,7,10-trioxa-2lambda~5~-aza-6lambda~5~-phosphaoctacosane-6,6,11-triol
  • ADP · Adenosine-5'-diphosphate
  • FES · Fe2/s2 (inorganic) cluster
  • FMN · Flavin mononucleotide
  • NDP · Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate
  • SF4 · Iron/sulfur cluster
  • MG · Magnesium ion
  • ZN · Zinc ion
  • NAI · 1,4-dihydronicotinamide adenine dinucleotide

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