NDP · Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate

Binding sites

NDP in 563 structures; the first of them:

• 4XRB · Crystal structure of Rv2671 from Mycobacterium tuberculosis · NDP A301 · binds PHE45, ILE46, ALA53, THR54, GLY57, THR58, SER59, GLY84 and 18 more
• 4XWY · Crystal structure of human sepiapterin reductase in complex with an N-acetylserotinin… · NDP A801 · binds GLY11, ALA12, SER13, ARG14, GLY15, PHE16, ALA38, ARG39 and 22 more
• 4ZQH · Crystal structure of DOX-P Reductoisomerase in complex with NADPH, fosmidomycin and… · NDP A501 · binds GLY12, ALA13, THR14, GLY15, SER16, ILE17, THR38, GLY39 and 20 more
• 5AZ1 · Crystal structure of aldo-keto reductase (AKR2E5) complexed with NADPH · NDP A409 · binds GLY23, THR24, TRP25, ASP70, TYR75, LYS104, HIS137, TRP138 and 21 more
• 5B1Y · Crystal structure of NADPH bound carbonyl reductase from Aeropyrum pernix · NDP A300 · binds GLY10, SER12, ARG13, GLY14, ILE15, GLY16, ALA33, TYR34 and 23 more
• 5C37 · Structure of the beta-ketoacyl reductase domain of human fatty acid synthase bound to a… · NDP A2201 · binds GLY1891, GLY1894, GLY1895, PHE1896, GLY1897, THR1915, SER1916, ARG1917 and 21 more
• 5DOZ · Crystal structure of JamJ enoyl reductase (NADPH bound) · NDP A502 · binds PHE45, ARG46, ILE134, THR138, ALA159, SER161, GLY162, GLY163 and 19 more
• 5FB3 · Structure of glycerophosphate dehydrogenase in complex with NADPH · NDP D1001 · binds GLY38, LYS39, SER40, SER41, THR42, TYR45, GLY80, GLY81 and 20 more
• 5G4L · Phloroglucinol reductase from Clostridium sp. with bound NADPH · NDP A1265 · binds THR26, GLY27, ALA28, LEU29, GLY48, ARG49, ASN50, PRO75 and 17 more
• 5G6R · Imine reductase from Aspergillus oryzae · NDP A1000 · binds GLY9, LEU10, GLY11, ALA12, MET13, GLY14, TRP31, ASN32 and 16 more
• 5G6S · Imine reductase from Aspergillus oryzae in complex with NADP(H) and (R)-rasagiline · NDP A300 · binds GLY9, LEU10, GLY11, ALA12, MET13, GLY14, ASN32, ARG33 and 17 more
• 5GPN · Architecture of mammalian respirasome · NDP p401 · binds GLY60, THR62, GLY63, PHE64, LEU65, ARG85, CYS86, LEU129 and 7 more
• 5GTL · NADPH complex structure of Aldehyde Dehydrogenase from Bacillus cereus · NDP A503 · binds ILE164, ILE165, PRO166, TRP167, ASN168, MET173, LYS191, ALA193 and 25 more
• 5GUD · Glutamate dehydrogenase from Corynebacterium glutamicum (alpha-iminoglutarate/NADP+… · NDP A502 · binds ARG96, HIS98, LEU109, LYS116, LYS136, ASP168, ILE169, GLY170 and 20 more

Residues it binds most

GLY 1158, SER 1117, ARG 1150, ALA 1091, ILE 1022, THR 1097, VAL 1135, LEU 1020, LYS 1032, ASN 762 (residue and the binding sites it lines).

Found with

• FMN · Flavin mononucleotide
• FES · Fe2/s2 (inorganic) cluster
• SF4 · Iron/sulfur cluster
• ZN · Zinc ion
• CDL · Cardiolipin
• MG · Magnesium ion
• 3PE · 1,2-diacyl-sn-glycero-3-phosphoethanolamine
• PC1 · 1,2-diacyl-sn-glycero-3-phosphocholine
• K · Potassium ion
• GOL · Glycerol
• MYR · Myristic acid
• NAI · 1,4-dihydronicotinamide adenine dinucleotide