UniProt Q7TMF3
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (Q7TMF3)
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (UniProt Q7TMF3): 23 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 32 pockets. Binding sites, druggability and experiment against…
- UniProt
- Q7TMF3
- Protein
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12
- Experimental structures
- 23
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 32 · 14 records with a druggable one
Structures
24 records of Q7TMF3 in the MolNFT archive: 23 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6G2J | Mouse mitochondrial complex I in the active state | electron microscopy | q | CDL, PC1 | 2 (best 0.82) |
| 6G2J | Mouse mitochondrial complex I in the active state | electron microscopy | q | CDL, PC1 | — |
| 6G72 | Mouse mitochondrial complex I in the deactive state | electron microscopy | q | — | — |
| 6ZR2 | Cryo-EM structure of respiratory complex I in the active state from Mus musculus at 3.1 A | electron microscopy | q | PC1, CDL | 2 (best 0.83) |
| 6ZR2 | Cryo-EM structure of respiratory complex I in the active state from mus musculus at 3.1 a | electron microscopy | q | PC1, CDL | — |
| 6ZTQ | Cryo-EM structure of respiratory complex I from mus musculus inhibited by piericidin a at 3.0 a | electron microscopy | q | PC1, CDL | — |
| 7AK5 | Cryo-EM structure of respiratory complex I in the deactive state from Mus musculus at 3.2 A | electron microscopy | q | PC1, CDL | — |
| 7AK5 | Cryo-EM structure of respiratory complex I in the deactive state from mus musculus at 3.2 a | electron microscopy | q | PC1, CDL | — |
| 7AK6 | Cryo-EM structure of ND6-P25L mutant respiratory complex I from mus musculus at 3.8 a | electron microscopy | q | PC1 | — |
| 7B93 | Cryo-EM structure of mitochondrial complex I from Mus musculus inhibited by IACS-2858 at 3.0 A | electron microscopy | q | PC1, CDL | 1 (best 0.82) |
| 7B93 | Cryo-EM structure of mitochondrial complex I from mus musculus inhibited by iacs-2858 at 3.0 a | electron microscopy | q | PC1, CDL | — |
| 8IAP | Respiratory complex Peripheral Arm of CI, focus-refined map of type I, Wild type mouse under… | electron microscopy | q | CDL, PC1 | 4 (best 0.78) |
| 8IB5 | Respiratory complex Peripheral Arm of CI, focus-refined map of type IA, Wild type mouse under cold… | electron microscopy | q | PC1, CDL | 2 (best 0.84) |
| 8IBD | Respiratory complex CI:CIII2, type II, Wild type mouse under cold temperature | electron microscopy | q | PC1, CDL | 1 (best 0.84) |
| 8IBE | Respiratory complex Peripheral Arm of CI, focus-refined map of type II, Wild type mouse under cold… | electron microscopy | q | PC1, CDL | 3 (best 0.83) |
| 8OM1 | Mitochondrial complex I from Mus musculus in the active state | electron microscopy | q | PC1, CDL | 2 (best 0.84) |
| 8PW6 | C respirasome from murine liver | electron microscopy | q1 | 3PE, CDL | 1 (best 0.83) |
| 8RGQ | Open Complex I from murine liver | electron microscopy | q | 3PE, CDL | 1 (best 0.84) |
| 8RGR | Closed Complex I from murine liver | electron microscopy | q | 3PE, CDL | 2 (best 0.84) |
| 8XNM | Respiratory complex Peripheral Arm of CI, close form B, focus-refined map of type I, Wild type… | electron microscopy | q | CDL, PC1 | 3 (best 0.87) |
| 8XNP | Respiratory complex Peripheral Arm of CI, close form B, focus-refined map of type IA, Wild type… | electron microscopy | q | PC1, CDL | 3 (best 0.81) |
| 8XNT | Respiratory complex Peripheral Arm of CI, close form C, focus-refined map of type IB, Wild type… | electron microscopy | q | — | — |
| 8XNW | Respiratory complex Peripheral Arm of CI, close form B, focus-refined map of type II, Wild type… | electron microscopy | q | PC1, CDL | 4 (best 0.83) |
| Q7TMF3 | AlphaFold monomer V2.0 prediction for NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12… | predicted | A | — | 1 (best 0.45) |
Ligands
Experiment against prediction
- 8OM1 chain q against the predicted model Q7TMF3: TM-score 0.97, RMSD 0.76 Å
- 8RGR chain q against the predicted model Q7TMF3: TM-score 0.97, RMSD 0.80 Å
- 7B93 chain q against the predicted model Q7TMF3: TM-score 0.97, RMSD 0.80 Å
- 7B93 chain q against the predicted model Q7TMF3: TM-score 0.97, RMSD 0.80 Å
- 8RGQ chain q against the predicted model Q7TMF3: TM-score 0.97, RMSD 0.83 Å
- 8PW6 chain q1 against the predicted model Q7TMF3: TM-score 0.97, RMSD 0.82 Å
- 8XNM chain q against the predicted model Q7TMF3: TM-score 0.97, RMSD 0.81 Å
- 8IAP chain q against the predicted model Q7TMF3: TM-score 0.97, RMSD 0.81 Å
- 6ZR2 chain q against the predicted model Q7TMF3: TM-score 0.97, RMSD 0.84 Å
- 6ZR2 chain q against the predicted model Q7TMF3: TM-score 0.97, RMSD 0.84 Å
Elsewhere
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