UniProt Q99LC3
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (Q99LC3)
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (UniProt Q99LC3): 14 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 15 pockets. Binding sites, druggability and experiment…
- UniProt
- Q99LC3
- Protein
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial
- Experimental structures
- 14
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 15 · 7 records with a druggable one
Structures
15 records of Q99LC3 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6G2J | Mouse mitochondrial complex I in the active state | electron microscopy | O | 3PE, ADP | 2 (best 0.85) |
| 6G2J | Mouse mitochondrial complex I in the active state | electron microscopy | O | 3PE, ADP | — |
| 6G72 | Mouse mitochondrial complex I in the deactive state | electron microscopy | O | ADP | — |
| 6ZR2 | Cryo-EM structure of respiratory complex I in the active state from mus musculus at 3.1 a | electron microscopy | O | CDL, ATP | — |
| 6ZTQ | Cryo-EM structure of respiratory complex I from mus musculus inhibited by piericidin a at 3.0 a | electron microscopy | O | CDL, ATP | — |
| 7AK5 | Cryo-EM structure of respiratory complex I in the deactive state from Mus musculus at 3.2 A | electron microscopy | O | 3PE, ATP | — |
| 7AK5 | Cryo-EM structure of respiratory complex I in the deactive state from mus musculus at 3.2 a | electron microscopy | O | 3PE, ATP | — |
| 7AK6 | Cryo-EM structure of ND6-P25L mutant respiratory complex I from mus musculus at 3.8 a | electron microscopy | O | ATP | — |
| 7B93 | Cryo-EM structure of mitochondrial complex I from mus musculus inhibited by iacs-2858 at 3.0 a | electron microscopy | O | CDL, ATP | — |
| 8IAQ | Respiratory complex Membrane domain of CI, focused map of type I, Wild type mouse under… | electron microscopy | O | ADP, CDL | 3 (best 0.82) |
| 8IBD | Respiratory complex CI:CIII2, type II, Wild type mouse under cold temperature | electron microscopy | O | 3PE, ADP | 1 (best 0.85) |
| 8IC4 | Respiratory complex Membrane domain of CI, focus-refined of type I, PERK -/- mouse under cold… | electron microscopy | O | ADP | 3 (best 0.83) |
| 8PW6 | C respirasome from murine liver | electron microscopy | O1 | CDL, DGT, MG | 1 (best 0.84) |
| 8RGR | Closed Complex I from murine liver | electron microscopy | O | CDL, DGT, MG | 2 (best 0.87) |
| Q99LC3 | AlphaFold monomer V2.0 prediction for NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit… | predicted | A | — | 3 (best 0.63) |
Ligands
Experiment against prediction
- 8RGR chain O against the predicted model Q99LC3: TM-score 0.99, RMSD 0.58 Å
- 8PW6 chain O1 against the predicted model Q99LC3: TM-score 0.99, RMSD 0.59 Å
- 7B93 chain O against the predicted model Q99LC3: TM-score 0.99, RMSD 0.58 Å
- 6ZR2 chain O against the predicted model Q99LC3: TM-score 0.99, RMSD 0.59 Å
- 6ZTQ chain O against the predicted model Q99LC3: TM-score 0.99, RMSD 0.61 Å
- 7AK5 chain O against the predicted model Q99LC3: TM-score 0.99, RMSD 0.65 Å
- 7AK5 chain O against the predicted model Q99LC3: TM-score 0.99, RMSD 0.65 Å
- 8IAQ chain O against the predicted model Q99LC3: TM-score 0.99, RMSD 0.66 Å
- 8IC4 chain O against the predicted model Q99LC3: TM-score 0.99, RMSD 0.68 Å
- 8IBD chain O against the predicted model Q99LC3: TM-score 0.99, RMSD 0.68 Å
Elsewhere
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