UniProt Q91WD5
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial (Q91WD5)
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial (UniProt Q91WD5), EC 1.6.5.3, 1.6.99.3: 17 experimental structures and 1 predicted model on GenesisL1, 8 ligands bound, 45 pockets. Binding sites, druggability…
- UniProt
- Q91WD5
- Protein
- NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial
- EC
- 1.6.5.3, 1.6.99.3, 7.1.1.2
- Experimental structures
- 17
- Predicted models
- 1
- Ligands
- 8
- Pockets
- 45 · 9 records with a druggable one
Structures
18 records of Q91WD5 in the MolNFT archive: 17 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6G2J | Mouse mitochondrial complex I in the active state | electron microscopy | D | SF4, 3PE | 4 (best 0.88) |
| 6G2J | Mouse mitochondrial complex I in the active state | electron microscopy | D | SF4, 3PE | — |
| 6G72 | Mouse mitochondrial complex I in the deactive state | electron microscopy | D | SF4 | — |
| 6ZR2 | Cryo-EM structure of respiratory complex I in the active state from mus musculus at 3.1 a | electron microscopy | D | SF4, 3PE | — |
| 6ZTQ | Cryo-EM structure of respiratory complex I from mus musculus inhibited by piericidin a at 3.0 a | electron microscopy | D | SF4, HQH, 3PE | — |
| 7AK5 | Cryo-EM structure of respiratory complex I in the deactive state from Mus musculus at 3.2 A | electron microscopy | D | SF4, 3PE | — |
| 7AK5 | Cryo-EM structure of respiratory complex I in the deactive state from mus musculus at 3.2 a | electron microscopy | D | SF4, 3PE | — |
| 7AK6 | Cryo-EM structure of ND6-P25L mutant respiratory complex I from mus musculus at 3.8 a | electron microscopy | D | SF4, 3PE | — |
| 7B93 | Cryo-EM structure of mitochondrial complex I from mus musculus inhibited by iacs-2858 at 3.0 a | electron microscopy | D | SF4, 3PE, T2Q | — |
| 8IAP | Respiratory complex Peripheral Arm of CI, focus-refined map of type I, Wild type mouse under… | electron microscopy | D | SF4, UQ1, 3PE, PC1 | 7 (best 0.86) |
| 8IAQ | Respiratory complex Membrane domain of CI, focused map of type I, Wild type mouse under… | electron microscopy | D | 3PE | 4 (best 0.79) |
| 8IBD | Respiratory complex CI:CIII2, type II, Wild type mouse under cold temperature | electron microscopy | D | SF4, UQ1, 3PE | 5 (best 0.87) |
| 8IBE | Respiratory complex Peripheral Arm of CI, focus-refined map of type II, Wild type mouse under cold… | electron microscopy | D | SF4, UQ1, 3PE | 7 (best 0.87) |
| 8IC4 | Respiratory complex Membrane domain of CI, focus-refined of type I, PERK -/- mouse under cold… | electron microscopy | D | 3PE | 4 (best 0.78) |
| 8PW6 | C respirasome from murine liver | electron microscopy | D1 | SF4, 3PE, PC1 | 2 (best 0.90) |
| 8RGR | Closed Complex I from murine liver | electron microscopy | D | SF4, UQ, 3PE, PC1 | 5 (best 0.89) |
| 8XNP | Respiratory complex Peripheral Arm of CI, close form B, focus-refined map of type IA, Wild type… | electron microscopy | D | SF4, UQ9, 3PE | 6 (best 0.89) |
| Q91WD5 | AlphaFold monomer V2.0 prediction for NADH dehydrogenase [ubiquinone] iron-sulfur protein 2… | predicted | A | — | 1 (best 0.31) |
Ligands
- 3PE · 1,2-diacyl-sn-glycero-3-phosphoethanolamine · in 16 records
- SF4 · Iron/sulfur cluster · in 15 records
- PC1 · 1,2-diacyl-sn-glycero-3-phosphocholine · in 3 records
- UQ1 · Ubiquinone-1 · in 3 records
- HQH · Piericidin A · in 1 record
- T2Q · 1-[[3-(4-methylsulfonylpiperidin-1-yl)phenyl]methyl]-5-[3-[4-(trifluoromethyloxy)phenyl]-1,2,4-oxadiazol-5-yl]pyridin-2-one · in 1 record
- UQ · Coenzyme Q10, (2Z,6E,10Z,14E,18E,22E,26Z)-isomer · in 1 record
- UQ9 · Ubiquinone-9 · in 1 record
Experiment against prediction
- 8IAP chain D against the predicted model Q91WD5: TM-score 0.99, RMSD 0.56 Å
- 8XNP chain D against the predicted model Q91WD5: TM-score 0.99, RMSD 0.57 Å
- 8IBE chain D against the predicted model Q91WD5: TM-score 0.99, RMSD 0.59 Å
- 7AK5 chain D against the predicted model Q91WD5: TM-score 0.98, RMSD 1.07 Å
- 7AK5 chain D against the predicted model Q91WD5: TM-score 0.98, RMSD 1.07 Å
- 7AK6 chain D against the predicted model Q91WD5: TM-score 0.98, RMSD 1.10 Å
- 6G72 chain D against the predicted model Q91WD5: TM-score 0.97, RMSD 1.31 Å
- 8IBD chain D against the predicted model Q91WD5: TM-score 0.97, RMSD 1.31 Å
- 8PW6 chain D1 against the predicted model Q91WD5: TM-score 0.96, RMSD 1.60 Å
- 8RGR chain D against the predicted model Q91WD5: TM-score 0.96, RMSD 1.66 Å
Elsewhere
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