UniProt Q91YT0
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (Q91YT0)
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (UniProt Q91YT0), EC 1.6.5.3, 1.6.99.3: 42 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 70 pockets. Binding sites, druggability and…
- UniProt
- Q91YT0
- Protein
- NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
- EC
- 1.6.5.3, 1.6.99.3, 7.1.1.2
- Experimental structures
- 42
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 70 · 20 records with a druggable one
Structures
43 records of Q91YT0 in the MolNFT archive: 42 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6G2J | Mouse mitochondrial complex I in the active state | electron microscopy | F | FES, FMN, SF4 | — |
| 6G2J | Mouse mitochondrial complex I in the active state | electron microscopy | F | FES, FMN, SF4 | — |
| 6G72 | Mouse mitochondrial complex I in the deactive state | electron microscopy | F | FES, FMN, SF4 | — |
| 6G72 | Mouse mitochondrial complex I in the deactive state | electron microscopy | F | FES, FMN, SF4 | — |
| 6ZR2 | Cryo-EM structure of respiratory complex I in the active state from Mus musculus at 3.1 A | electron microscopy | F | FES, FMN, SF4 | — |
| 6ZR2 | Cryo-EM structure of respiratory complex I in the active state from mus musculus at 3.1 a | electron microscopy | F | FMN, SF4 | — |
| 6ZTQ | Cryo-EM structure of respiratory complex I from Mus musculus inhibited by piericidin A at 3.0 A | electron microscopy | F | FES, FMN, SF4 | — |
| 6ZTQ | Cryo-EM structure of respiratory complex I from mus musculus inhibited by piericidin a at 3.0 a | electron microscopy | F | FMN, SF4 | — |
| 7AK5 | Cryo-EM structure of respiratory complex I in the deactive state from Mus musculus at 3.2 A | electron microscopy | F | FMN, SF4 | — |
| 7AK5 | Cryo-EM structure of respiratory complex I in the deactive state from mus musculus at 3.2 a | electron microscopy | F | FMN, SF4 | — |
| 7AK6 | Cryo-EM structure of ND6-P25L mutant respiratory complex I from mus musculus at 3.8 a | electron microscopy | F | FMN, SF4 | — |
| 7B93 | Cryo-EM structure of mitochondrial complex I from Mus musculus inhibited by IACS-2858 at 3.0 A | electron microscopy | F | FES, FMN, SF4 | — |
| 7B93 | Cryo-EM structure of mitochondrial complex I from mus musculus inhibited by iacs-2858 at 3.0 a | electron microscopy | F | FMN, SF4 | — |
| 7PSA | The acetogenin-bound complex I of Mus musculus resolved to 3.4 angstroms | electron microscopy | F | FES, SF4, FMN | — |
| 8C2S | Cryo-EM structure NDUFS4 knockout complex I from Mus musculus heart (Class 1). | electron microscopy | F | FES, SF4, FMN | — |
| 8CA3 | Cryo-EM structure NDUFS4 knockout complex I from Mus musculus heart (Class 2). | electron microscopy | F | FES, SF4, FMN | — |
| 8CA4 | Cryo-EM structure NDUFS4 knockout complex I from Mus musculus heart (Class 2 N-domain). | electron microscopy | F | FES, SF4, FMN | 7 (best 0.77) |
| 8IAP | Respiratory complex Peripheral Arm of CI, focus-refined map of type I, Wild type mouse under… | electron microscopy | F | FES, FMN, SF4 | 4 (best 0.80) |
| 8IB4 | Respiratory complex CI:CIII2, type IA, Wild type mouse under cold temperature | electron microscopy | F | FES, FMN, SF4 | — |
| 8IB5 | Respiratory complex Peripheral Arm of CI, focus-refined map of type IA, Wild type mouse under cold… | electron microscopy | F | FES, FMN, SF4 | 3 (best 0.79) |
| 8IB9 | Respiratory complex CI:CIII2, type IB, Wild type mouse under cold temperature | electron microscopy | F | FES, FMN, SF4 | — |
| 8IBD | Respiratory complex CI:CIII2, type II, Wild type mouse under cold temperature | electron microscopy | F | FES, FMN, SF4 | — |
| 8IBE | Respiratory complex Peripheral Arm of CI, focus-refined map of type II, Wild type mouse under cold… | electron microscopy | F | FES, FMN, SF4 | 4 (best 0.79) |
| 8IC2 | Respiratory complex CI:CIII2, type I, PERK -/- mouse under cold temperature | electron microscopy | F | FES, FMN, SF4 | 1 (best 0.80) |
| 8OM1 | Mitochondrial complex I from Mus musculus in the active state | electron microscopy | F | FES, SF4, FMN | 1 (best 0.80) |
| 8PW6 | C respirasome from murine liver | electron microscopy | 1 | FES, FMN, SF4 | — |
| 8PW7 | A respirasome from murine liver | electron microscopy | 1 | FES, FMN, SF4 | — |
| 8RGP | Closed Complex I from murine brain | electron microscopy | 1 | FES, FMN, SF4 | 1 (best 0.79) |
| 8RGQ | Open Complex I from murine liver | electron microscopy | 1 | FES, FMN, SF4 | — |
| 8RGR | Closed Complex I from murine liver | electron microscopy | 1 | FES, FMN, SF4 | — |
| 8XNL | Respiratory complex Peripheral Arm of CI, close form A, focus-refined map of type I, Wild type… | electron microscopy | F | FES, FMN, SF4 | 3 (best 0.80) |
| 8XNM | Respiratory complex Peripheral Arm of CI, close form B, focus-refined map of type I, Wild type… | electron microscopy | F | FES, FMN, SF4 | 4 (best 0.79) |
| 8XNO | Respiratory complex Peripheral Arm of CI, close form A, focus-refined map of type IA, Wild type… | electron microscopy | F | FES, FMN, SF4 | 4 (best 0.79) |
| 8XNP | Respiratory complex Peripheral Arm of CI, close form B, focus-refined map of type IA, Wild type… | electron microscopy | F | FES, FMN, SF4 | 4 (best 0.79) |
| 8XNS | Respiratory complex Peripheral Arm of CI, close form B, focus-refined map of type IB, Wild type… | electron microscopy | F | FES, FMN, SF4 | 4 (best 0.79) |
| 8XNT | Respiratory complex Peripheral Arm of CI, close form C, focus-refined map of type IB, Wild type… | electron microscopy | F | FES, FMN, SF4 | 4 (best 0.79) |
| 8XNU | Respiratory complex Peripheral Arm of CI, open form A, focus-refined map of type IB, Wild type… | electron microscopy | F | FES, FMN, SF4 | 4 (best 0.79) |
| 8XNV | Respiratory complex Peripheral Arm of CI, close form A, focus-refined map of type II, Wild type… | electron microscopy | F | FES, FMN, SF4 | 4 (best 0.79) |
| 8XNW | Respiratory complex Peripheral Arm of CI, close form B, focus-refined map of type II, Wild type… | electron microscopy | F | FES, FMN, SF4 | 4 (best 0.77) |
| 8XNX | Respiratory complex Peripheral Arm of CI, open form A, focus-refined map of type II, Wild type… | electron microscopy | F | FES, FMN, SF4 | 4 (best 0.78) |
| 8XNY | Respiratory complex Peripheral Arm of CI, open form B, focus-refined map of type II, Wild type… | electron microscopy | F | FES, FMN, SF4 | 4 (best 0.78) |
| 8XNZ | Respiratory complex Peripheral Arm of CI, close form A, focus-refined map of type I, PERK -/- mouse… | electron microscopy | F | FES, FMN, SF4 | 4 (best 0.80) |
| Q91YT0 | AlphaFold monomer V2.0 prediction for NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial… | predicted | A | — | 2 (best 0.75) |
Ligands
Experiment against prediction
- 8OM1 chain F against the predicted model Q91YT0: TM-score 1.00, RMSD 0.33 Å
- 8RGR chain 1 against the predicted model Q91YT0: TM-score 1.00, RMSD 0.33 Å
- 8RGQ chain 1 against the predicted model Q91YT0: TM-score 1.00, RMSD 0.35 Å
- 8RGP chain 1 against the predicted model Q91YT0: TM-score 1.00, RMSD 0.38 Å
- 8CA4 chain F against the predicted model Q91YT0: TM-score 1.00, RMSD 0.39 Å
- 8PW6 chain 1 against the predicted model Q91YT0: TM-score 1.00, RMSD 0.39 Å
- 8PW7 chain 1 against the predicted model Q91YT0: TM-score 1.00, RMSD 0.39 Å
- 8CA3 chain F against the predicted model Q91YT0: TM-score 1.00, RMSD 0.43 Å
- 7B93 chain F against the predicted model Q91YT0: TM-score 1.00, RMSD 0.48 Å
- 7B93 chain F against the predicted model Q91YT0: TM-score 1.00, RMSD 0.48 Å
Elsewhere
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