UniProt Q99LY9
NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 (Q99LY9)
NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 (UniProt Q99LY9): 37 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 82 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q99LY9
- Protein
- NADH dehydrogenase [ubiquinone] iron-sulfur protein 5
- Experimental structures
- 37
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 82 · 29 records with a druggable one
Structures
38 records of Q99LY9 in the MolNFT archive: 37 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6G2J | Mouse mitochondrial complex I in the active state | electron microscopy | e | — | 3 (best 0.85) |
| 6G2J | Mouse mitochondrial complex I in the active state | electron microscopy | e | — | — |
| 6G72 | Mouse mitochondrial complex I in the deactive state | electron microscopy | e | — | 4 (best 0.85) |
| 6G72 | Mouse mitochondrial complex I in the deactive state | electron microscopy | e | — | — |
| 6ZR2 | Cryo-EM structure of respiratory complex I in the active state from Mus musculus at 3.1 A | electron microscopy | e | CDL | 3 (best 0.90) |
| 6ZR2 | Cryo-EM structure of respiratory complex I in the active state from mus musculus at 3.1 a | electron microscopy | e | CDL | — |
| 6ZTQ | Cryo-EM structure of respiratory complex I from Mus musculus inhibited by piericidin A at 3.0 A | electron microscopy | e | CDL | 3 (best 0.89) |
| 6ZTQ | Cryo-EM structure of respiratory complex I from mus musculus inhibited by piericidin a at 3.0 a | electron microscopy | e | CDL | — |
| 7AK5 | Cryo-EM structure of respiratory complex I in the deactive state from Mus musculus at 3.2 A | electron microscopy | e | — | — |
| 7AK5 | Cryo-EM structure of respiratory complex I in the deactive state from mus musculus at 3.2 a | electron microscopy | e | — | — |
| 7AK6 | Cryo-EM structure of ND6-P25L mutant respiratory complex I from Mus musculus at 3.8 A | electron microscopy | e | — | 3 (best 0.88) |
| 7AK6 | Cryo-EM structure of ND6-P25L mutant respiratory complex I from mus musculus at 3.8 a | electron microscopy | e | — | — |
| 7B93 | Cryo-EM structure of mitochondrial complex I from Mus musculus inhibited by IACS-2858 at 3.0 A | electron microscopy | e | CDL | 3 (best 0.89) |
| 7B93 | Cryo-EM structure of mitochondrial complex I from mus musculus inhibited by iacs-2858 at 3.0 a | electron microscopy | e | CDL | — |
| 7PSA | The acetogenin-bound complex I of Mus musculus resolved to 3.4 angstroms | electron microscopy | e | CDL | 3 (best 0.86) |
| 8C2S | Cryo-EM structure NDUFS4 knockout complex I from Mus musculus heart (Class 1). | electron microscopy | e | CDL | 3 (best 0.89) |
| 8CA3 | Cryo-EM structure NDUFS4 knockout complex I from Mus musculus heart (Class 2). | electron microscopy | e | CDL | 3 (best 0.90) |
| 8CA5 | Cryo-EM structure NDUFS4 knockout complex I from Mus musculus heart (Class 3). | electron microscopy | e | CDL | 3 (best 0.89) |
| 8IAO | Respiratory complex CI:CIII2, type I, Wild type mouse under thermoneutral temperature | electron microscopy | e | CDL | 3 (best 0.90) |
| 8IAQ | Respiratory complex Membrane domain of CI, focused map of type I, Wild type mouse under… | electron microscopy | e | CDL | 2 (best 0.84) |
| 8IB4 | Respiratory complex CI:CIII2, type IA, Wild type mouse under cold temperature | electron microscopy | e | 3PE | 3 (best 0.90) |
| 8IB6 | Respiratory complex Membrane domain of CI, focus-refined of type IA, Wild type mouse under cold… | electron microscopy | e | 3PE | 2 (best 0.84) |
| 8IB9 | Respiratory complex CI:CIII2, type IB, Wild type mouse under cold temperature | electron microscopy | e | — | 3 (best 0.90) |
| 8IBB | Respiratory complex Membrane domain of CI, focus-refined of type IB, Wild type mouse under cold… | electron microscopy | e | — | 2 (best 0.85) |
| 8IBD | Respiratory complex CI:CIII2, type II, Wild type mouse under cold temperature | electron microscopy | e | — | 3 (best 0.90) |
| 8IBF | Respiratory complex Membrane domain of CI, focus-refined of type II, Wild type mouse under cold… | electron microscopy | e | — | 2 (best 0.84) |
| 8IC2 | Respiratory complex CI:CIII2, type I, PERK -/- mouse under cold temperature | electron microscopy | e | — | 4 (best 0.87) |
| 8IC4 | Respiratory complex Membrane domain of CI, focus-refined of type I, PERK -/- mouse under cold… | electron microscopy | e | — | 1 (best 0.84) |
| 8OLT | Mitochondrial complex I from Mus musculus in the active state bound with piericidin A | electron microscopy | e | — | 3 (best 0.90) |
| 8OM1 | Mitochondrial complex I from Mus musculus in the active state | electron microscopy | e | — | 3 (best 0.90) |
| 8PW5 | CS respirasome from murine liver | electron microscopy | e1 | 3PE | 2 (best 0.89) |
| 8PW6 | C respirasome from murine liver | electron microscopy | e1 | — | 3 (best 0.88) |
| 8PW7 | A respirasome from murine liver | electron microscopy | e1 | — | 3 (best 0.89) |
| 8RGP | Closed Complex I from murine brain | electron microscopy | e | — | 3 (best 0.89) |
| 8RGQ | Open Complex I from murine liver | electron microscopy | e | 3PE | 3 (best 0.91) |
| 8RGR | Closed Complex I from murine liver | electron microscopy | e | 3PE | 3 (best 0.89) |
| 8RGT | Open Complex I from murine brain | electron microscopy | e | — | 3 (best 0.88) |
| Q99LY9 | AlphaFold monomer V2.0 prediction for NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 (Q99LY9) | predicted | A | — | — |
Ligands
Experiment against prediction
- 8RGP chain e against the predicted model Q99LY9: TM-score 0.95, RMSD 0.97 Å
- 8CA3 chain e against the predicted model Q99LY9: TM-score 0.94, RMSD 1.15 Å
- 8RGQ chain e against the predicted model Q99LY9: TM-score 0.94, RMSD 1.14 Å
- 8OM1 chain e against the predicted model Q99LY9: TM-score 0.94, RMSD 1.18 Å
- 8PW6 chain e1 against the predicted model Q99LY9: TM-score 0.94, RMSD 1.15 Å
- 8RGR chain e against the predicted model Q99LY9: TM-score 0.94, RMSD 1.17 Å
- 8RGT chain e against the predicted model Q99LY9: TM-score 0.94, RMSD 1.15 Å
- 8OLT chain e against the predicted model Q99LY9: TM-score 0.94, RMSD 1.19 Å
- 8CA5 chain e against the predicted model Q99LY9: TM-score 0.94, RMSD 1.17 Å
- 8PW5 chain e1 against the predicted model Q99LY9: TM-score 0.94, RMSD 1.19 Å
Elsewhere
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