UniProt Q91VD9

NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial (Q91VD9)

NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial (UniProt Q91VD9), EC 1.6.5.3, 1.6.99.3: 42 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 185 pockets. Binding sites, druggability and…

UniProt: Q91VD9
Protein: NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
EC: 1.6.5.3, 1.6.99.3, 7.1.1.2
Experimental structures: 42
Predicted models: 1
Ligands: 4
Pockets: 185 · 34 records with a druggable one

Structures

43 records of Q91VD9 in the MolNFT archive: 42 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
6G2J	Mouse mitochondrial complex I in the active state	electron microscopy	G	SF4, FES	3 (best 0.87)
6G2J	Mouse mitochondrial complex I in the active state	electron microscopy	G	SF4, FES	—
6G72	Mouse mitochondrial complex I in the deactive state	electron microscopy	G	SF4, FES	2 (best 0.89)
6G72	Mouse mitochondrial complex I in the deactive state	electron microscopy	G	SF4, FES	—
6ZR2	Cryo-EM structure of respiratory complex I in the active state from Mus musculus at 3.1 A	electron microscopy	G	SF4, FES	3 (best 0.87)
6ZR2	Cryo-EM structure of respiratory complex I in the active state from mus musculus at 3.1 a	electron microscopy	G	SF4, FES	—
6ZTQ	Cryo-EM structure of respiratory complex I from Mus musculus inhibited by piericidin A at 3.0 A	electron microscopy	G	SF4, FES	4 (best 0.87)
6ZTQ	Cryo-EM structure of respiratory complex I from mus musculus inhibited by piericidin a at 3.0 a	electron microscopy	G	SF4, FES	—
7AK5	Cryo-EM structure of respiratory complex I in the deactive state from Mus musculus at 3.2 A	electron microscopy	G	SF4, FES	—
7AK5	Cryo-EM structure of respiratory complex I in the deactive state from mus musculus at 3.2 a	electron microscopy	G	SF4, FES	—
7AK6	Cryo-EM structure of ND6-P25L mutant respiratory complex I from mus musculus at 3.8 a	electron microscopy	G	SF4, FES	—
7B93	Cryo-EM structure of mitochondrial complex I from Mus musculus inhibited by IACS-2858 at 3.0 A	electron microscopy	G	SF4, FES	4 (best 0.88)
7B93	Cryo-EM structure of mitochondrial complex I from mus musculus inhibited by iacs-2858 at 3.0 a	electron microscopy	G	SF4, FES	—
7PSA	The acetogenin-bound complex I of Mus musculus resolved to 3.4 angstroms	electron microscopy	G	SF4, FES	3 (best 0.86)
8C2S	Cryo-EM structure NDUFS4 knockout complex I from Mus musculus heart (Class 1).	electron microscopy	G	SF4, FES	—
8CA3	Cryo-EM structure NDUFS4 knockout complex I from Mus musculus heart (Class 2).	electron microscopy	G	SF4, FES	1 (best 0.79)
8CA4	Cryo-EM structure NDUFS4 knockout complex I from Mus musculus heart (Class 2 N-domain).	electron microscopy	G	SF4, FES	11 (best 0.77)
8IAP	Respiratory complex Peripheral Arm of CI, focus-refined map of type I, Wild type mouse under…	electron microscopy	G	SF4, FES	6 (best 0.86)
8IB4	Respiratory complex CI:CIII2, type IA, Wild type mouse under cold temperature	electron microscopy	G	SF4, FES	2 (best 0.83)
8IB5	Respiratory complex Peripheral Arm of CI, focus-refined map of type IA, Wild type mouse under cold…	electron microscopy	G	SF4, FES	7 (best 0.84)
8IB9	Respiratory complex CI:CIII2, type IB, Wild type mouse under cold temperature	electron microscopy	G	SF4, FES	2 (best 0.87)
8IBD	Respiratory complex CI:CIII2, type II, Wild type mouse under cold temperature	electron microscopy	G	SF4, FES	1 (best 0.86)
8IBE	Respiratory complex Peripheral Arm of CI, focus-refined map of type II, Wild type mouse under cold…	electron microscopy	G	SF4, FES	9 (best 0.87)
8IC2	Respiratory complex CI:CIII2, type I, PERK -/- mouse under cold temperature	electron microscopy	G	SF4, FES	2 (best 0.83)
8OM1	Mitochondrial complex I from Mus musculus in the active state	electron microscopy	G	SF4, FES, NA	3 (best 0.89)
8PW6	C respirasome from murine liver	electron microscopy	3	SF4, FES, K	2 (best 0.90)
8PW7	A respirasome from murine liver	electron microscopy	3	SF4, FES, K	2 (best 0.90)
8RGP	Closed Complex I from murine brain	electron microscopy	3	SF4, FES, K	4 (best 0.89)
8RGQ	Open Complex I from murine liver	electron microscopy	3	SF4, FES, K	2 (best 0.90)
8RGR	Closed Complex I from murine liver	electron microscopy	3	SF4, FES, K	4 (best 0.89)
8XNL	Respiratory complex Peripheral Arm of CI, close form A, focus-refined map of type I, Wild type…	electron microscopy	G	SF4, FES	6 (best 0.87)
8XNM	Respiratory complex Peripheral Arm of CI, close form B, focus-refined map of type I, Wild type…	electron microscopy	G	SF4, FES	8 (best 0.88)
8XNO	Respiratory complex Peripheral Arm of CI, close form A, focus-refined map of type IA, Wild type…	electron microscopy	G	SF4, FES	9 (best 0.87)
8XNP	Respiratory complex Peripheral Arm of CI, close form B, focus-refined map of type IA, Wild type…	electron microscopy	G	SF4, FES	9 (best 0.87)
8XNS	Respiratory complex Peripheral Arm of CI, close form B, focus-refined map of type IB, Wild type…	electron microscopy	G	SF4, FES	8 (best 0.87)
8XNT	Respiratory complex Peripheral Arm of CI, close form C, focus-refined map of type IB, Wild type…	electron microscopy	G	SF4, FES	8 (best 0.83)
8XNU	Respiratory complex Peripheral Arm of CI, open form A, focus-refined map of type IB, Wild type…	electron microscopy	G	SF4, FES	8 (best 0.85)
8XNV	Respiratory complex Peripheral Arm of CI, close form A, focus-refined map of type II, Wild type…	electron microscopy	G	SF4, FES	8 (best 0.87)
8XNW	Respiratory complex Peripheral Arm of CI, close form B, focus-refined map of type II, Wild type…	electron microscopy	G	SF4, FES	9 (best 0.87)
8XNX	Respiratory complex Peripheral Arm of CI, open form A, focus-refined map of type II, Wild type…	electron microscopy	G	SF4, FES	11 (best 0.87)
8XNY	Respiratory complex Peripheral Arm of CI, open form B, focus-refined map of type II, Wild type…	electron microscopy	G	SF4, FES	8 (best 0.86)
8XNZ	Respiratory complex Peripheral Arm of CI, close form A, focus-refined map of type I, PERK -/- mouse…	electron microscopy	G	SF4, FES	8 (best 0.87)
Q91VD9	AlphaFold monomer V2.0 prediction for NADH-ubiquinone oxidoreductase 75 kda subunit, mitochondrial…	predicted	A	—	8 (best 0.70)

Ligands

FES · Fe2/s2 (inorganic) cluster · in 42 records
SF4 · Iron/sulfur cluster · in 42 records
K · Potassium ion · in 5 records
NA · Sodium ion · in 1 record

Experiment against prediction

8OM1 chain G against the predicted model Q91VD9: TM-score 1.00, RMSD 0.52 Å
8RGR chain 3 against the predicted model Q91VD9: TM-score 1.00, RMSD 0.54 Å
8RGQ chain 3 against the predicted model Q91VD9: TM-score 1.00, RMSD 0.54 Å
8PW7 chain 3 against the predicted model Q91VD9: TM-score 1.00, RMSD 0.56 Å
8RGP chain 3 against the predicted model Q91VD9: TM-score 1.00, RMSD 0.58 Å
7PSA chain G against the predicted model Q91VD9: TM-score 1.00, RMSD 0.58 Å
7B93 chain G against the predicted model Q91VD9: TM-score 1.00, RMSD 0.58 Å
7B93 chain G against the predicted model Q91VD9: TM-score 1.00, RMSD 0.58 Å
8PW6 chain 3 against the predicted model Q91VD9: TM-score 1.00, RMSD 0.60 Å
8IBD chain G against the predicted model Q91VD9: TM-score 1.00, RMSD 0.60 Å

Elsewhere

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