MolNFT v1 · #262662 · protein
AlphaFold monomer V2.0 prediction for NADH-ubiquinone oxidoreductase 75 kda subunit, mitochondrial (Q91VD9)
Q91VD9: “AlphaFold monomer V2.0 prediction for NADH-ubiquinone oxidoreductase 75 kda subunit, mitochondrial (Q91VD9)”. 8 pockets (best druggability 0.70). MolNFT v1 #262662 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- Q91VD9
- Type
- protein
- Length
- 727 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x477d4b69908956afCebfE8CC0A108d7C987af145
- Molecule
- NADH-ubiquinone oxidoreductase 75 kda subunit, mitochondrial
- UniProt
- Q91VD9
- Pockets
- 8 · best druggability 0.70
Structure
1 distinct chain · 32% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | NADH-ubiquinone oxidoreductase 75 kda subunit, mitochondrial | protein | 727 | 32% helix, 17% strand | Q91VD9 |
Pockets
8 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 53 | 0.70 | 0.97 | 24 | empty |
| 2 | 182 | 0.63 | 0.84 | 40 | empty |
| 3 | 387 | 0.62 | 0.77 | 42 | empty |
| 4 | 131 | 0.49 | 0.79 | 29 | empty |
| 5 | 89 | 0.36 | 0.75 | 18 | empty |
Compared structures
- 8RGR · Closed Complex I from murine liver · an experimental structure of the same protein · chain A against 3, TM-score 0.95
- 8RGQ · Open Complex I from murine liver · an experimental structure of the same protein · chain A against 3, TM-score 0.95
- 8RGT · Open Complex I from murine brain · an experimental structure of the same protein · chain A against 3, TM-score 0.95
- 8PW7 · A respirasome from murine liver · an experimental structure of the same protein · chain A against 3, TM-score 0.95
- 8PW5 · CS respirasome from murine liver · an experimental structure of the same protein · chain A against 3, TM-score 0.95
- 8RGP · Closed Complex I from murine brain · an experimental structure of the same protein · chain A against 3, TM-score 0.95
- 7B93 · Cryo-EM structure of mitochondrial complex I from Mus musculus inhibited by IACS-2858 at… · an experimental structure of the same protein · chain A against G, TM-score 0.95
- 7B93 · Cryo-EM structure of mitochondrial complex I from mus musculus inhibited by iacs-2858 at… · an experimental structure of the same protein · chain A against G, TM-score 0.95
- 8PW6 · C respirasome from murine liver · an experimental structure of the same protein · chain A against 3, TM-score 0.95
- 8OM1 · Mitochondrial complex I from Mus musculus in the active state · an experimental structure of the same protein · chain A against G, TM-score 0.94
- 8OLT · Mitochondrial complex I from Mus musculus in the active state bound with piericidin A · an experimental structure of the same protein · chain A against G, TM-score 0.94
- 7PSA · The acetogenin-bound complex I of Mus musculus resolved to 3.4 angstroms · an experimental structure of the same protein · chain A against G, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q91VD9
- Elsewhere: UniProt Q91VD9 · AlphaFold DB Q91VD9
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