UniProt Q9DC69
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial (Q9DC69)
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial (UniProt Q9DC69): 26 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 86 pockets. Binding sites, druggability and experiment…
- UniProt
- Q9DC69
- Protein
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial
- Experimental structures
- 26
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 86 · 19 records with a druggable one
Structures
27 records of Q9DC69 in the MolNFT archive: 26 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6G2J | Mouse mitochondrial complex I in the active state | electron microscopy | P | PC1, NDP | 4 (best 0.88) |
| 6G2J | Mouse mitochondrial complex I in the active state | electron microscopy | P | PC1, NDP | — |
| 6G72 | Mouse mitochondrial complex I in the deactive state | electron microscopy | P | NDP | — |
| 6ZR2 | Cryo-EM structure of respiratory complex I in the active state from Mus musculus at 3.1 A | electron microscopy | P | PC1, NDP | 5 (best 0.87) |
| 6ZR2 | Cryo-EM structure of respiratory complex I in the active state from mus musculus at 3.1 a | electron microscopy | P | PC1, NDP | — |
| 6ZTQ | Cryo-EM structure of respiratory complex I from Mus musculus inhibited by piericidin A at 3.0 A | electron microscopy | P | PC1, NDP | 4 (best 0.88) |
| 6ZTQ | Cryo-EM structure of respiratory complex I from mus musculus inhibited by piericidin a at 3.0 a | electron microscopy | P | PC1, NDP | — |
| 7AK5 | Cryo-EM structure of respiratory complex I in the deactive state from Mus musculus at 3.2 A | electron microscopy | P | NDP | — |
| 7AK5 | Cryo-EM structure of respiratory complex I in the deactive state from mus musculus at 3.2 a | electron microscopy | P | NDP | — |
| 7AK6 | Cryo-EM structure of ND6-P25L mutant respiratory complex I from mus musculus at 3.8 a | electron microscopy | P | NDP | — |
| 7B93 | Cryo-EM structure of mitochondrial complex I from Mus musculus inhibited by IACS-2858 at 3.0 A | electron microscopy | P | PC1, NDP | 4 (best 0.87) |
| 7B93 | Cryo-EM structure of mitochondrial complex I from mus musculus inhibited by iacs-2858 at 3.0 a | electron microscopy | P | PC1, NDP | — |
| 8C2S | Cryo-EM structure NDUFS4 knockout complex I from Mus musculus heart (Class 1). | electron microscopy | P | PC1, NAP | 1 (best 0.86) |
| 8CA3 | Cryo-EM structure NDUFS4 knockout complex I from Mus musculus heart (Class 2). | electron microscopy | P | PC1, NDP | 2 (best 0.88) |
| 8IAP | Respiratory complex Peripheral Arm of CI, focus-refined map of type I, Wild type mouse under… | electron microscopy | P | NDP | 7 (best 0.85) |
| 8IB5 | Respiratory complex Peripheral Arm of CI, focus-refined map of type IA, Wild type mouse under cold… | electron microscopy | P | PC1, NDP | 5 (best 0.85) |
| 8IBD | Respiratory complex CI:CIII2, type II, Wild type mouse under cold temperature | electron microscopy | P | PC1, NDP | 4 (best 0.86) |
| 8IBE | Respiratory complex Peripheral Arm of CI, focus-refined map of type II, Wild type mouse under cold… | electron microscopy | P | PC1, NDP | 6 (best 0.87) |
| 8OM1 | Mitochondrial complex I from Mus musculus in the active state | electron microscopy | P | PC1, CDL, NDP | 4 (best 0.86) |
| 8PW6 | C respirasome from murine liver | electron microscopy | P1 | PC1, NDP, CDL | 4 (best 0.90) |
| 8RGQ | Open Complex I from murine liver | electron microscopy | P | PC1, NDP | 3 (best 0.87) |
| 8RGR | Closed Complex I from murine liver | electron microscopy | P | PC1, NDP, CDL | 5 (best 0.87) |
| 8XNM | Respiratory complex Peripheral Arm of CI, close form B, focus-refined map of type I, Wild type… | electron microscopy | P | NDP | 6 (best 0.87) |
| 8XNP | Respiratory complex Peripheral Arm of CI, close form B, focus-refined map of type IA, Wild type… | electron microscopy | P | PC1, NDP | 6 (best 0.88) |
| 8XNT | Respiratory complex Peripheral Arm of CI, close form C, focus-refined map of type IB, Wild type… | electron microscopy | P | NDP | 5 (best 0.85) |
| 8XNW | Respiratory complex Peripheral Arm of CI, close form B, focus-refined map of type II, Wild type… | electron microscopy | P | NDP | 6 (best 0.87) |
| Q9DC69 | AlphaFold monomer V2.0 prediction for NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9… | predicted | A | — | 5 (best 0.79) |
Ligands
Experiment against prediction
- 8OM1 chain P against the predicted model Q9DC69: TM-score 0.99, RMSD 0.56 Å
- 8CA3 chain P against the predicted model Q9DC69: TM-score 0.99, RMSD 0.58 Å
- 8RGR chain P against the predicted model Q9DC69: TM-score 0.99, RMSD 0.60 Å
- 7B93 chain P against the predicted model Q9DC69: TM-score 0.99, RMSD 0.60 Å
- 7B93 chain P against the predicted model Q9DC69: TM-score 0.99, RMSD 0.60 Å
- 8C2S chain P against the predicted model Q9DC69: TM-score 0.99, RMSD 0.59 Å
- 8PW6 chain P1 against the predicted model Q9DC69: TM-score 0.99, RMSD 0.62 Å
- 8RGQ chain P against the predicted model Q9DC69: TM-score 0.99, RMSD 0.61 Å
- 6ZTQ chain P against the predicted model Q9DC69: TM-score 0.99, RMSD 0.64 Å
- 6ZTQ chain P against the predicted model Q9DC69: TM-score 0.99, RMSD 0.64 Å
Elsewhere
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