UniProt P03921
NADH-ubiquinone oxidoreductase chain 5 (P03921)
NADH-ubiquinone oxidoreductase chain 5 (UniProt P03921), EC 1.6.5.3, 7.1.1.2: 32 experimental structures on GenesisL1, 6 ligands bound, 151 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P03921
- Protein
- NADH-ubiquinone oxidoreductase chain 5
- EC
- 1.6.5.3, 7.1.1.2
- Experimental structures
- 32
- Predicted models
- 0
- Ligands
- 6
- Pockets
- 151 · 23 records with a druggable one
Structures
32 records of P03921 in the MolNFT archive: 32 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6G2J | Mouse mitochondrial complex I in the active state | electron microscopy | L | 3PE, CDL, EHZ | 6 (best 0.88) |
| 6G2J | Mouse mitochondrial complex I in the active state | electron microscopy | L | 3PE, CDL, EHZ | — |
| 6G72 | Mouse mitochondrial complex I in the deactive state | electron microscopy | L | EHZ | 6 (best 0.88) |
| 6G72 | Mouse mitochondrial complex I in the deactive state | electron microscopy | L | — | — |
| 6ZR2 | Cryo-EM structure of respiratory complex I in the active state from Mus musculus at 3.1 A | electron microscopy | L | 3PE, CDL | 5 (best 0.84) |
| 6ZR2 | Cryo-EM structure of respiratory complex I in the active state from mus musculus at 3.1 a | electron microscopy | L | 3PE, CDL | — |
| 6ZTQ | Cryo-EM structure of respiratory complex I from Mus musculus inhibited by piericidin A at 3.0 A | electron microscopy | L | 3PE, CDL | 5 (best 0.83) |
| 6ZTQ | Cryo-EM structure of respiratory complex I from mus musculus inhibited by piericidin a at 3.0 a | electron microscopy | L | 3PE, CDL | — |
| 7AK5 | Cryo-EM structure of respiratory complex I in the deactive state from Mus musculus at 3.2 A | electron microscopy | L | 3PE, CDL | — |
| 7AK5 | Cryo-EM structure of respiratory complex I in the deactive state from mus musculus at 3.2 a | electron microscopy | L | 3PE, CDL | — |
| 7AK6 | Cryo-EM structure of ND6-P25L mutant respiratory complex I from mus musculus at 3.8 a | electron microscopy | L | 3PE, CDL | — |
| 7B93 | Cryo-EM structure of mitochondrial complex I from Mus musculus inhibited by IACS-2858 at 3.0 A | electron microscopy | L | 3PE, CDL | 7 (best 0.89) |
| 7B93 | Cryo-EM structure of mitochondrial complex I from mus musculus inhibited by iacs-2858 at 3.0 a | electron microscopy | L | 3PE, CDL | — |
| 7PSA | The acetogenin-bound complex I of Mus musculus resolved to 3.4 angstroms | electron microscopy | L | 3PE, CDL | 7 (best 0.88) |
| 8C2S | Cryo-EM structure NDUFS4 knockout complex I from Mus musculus heart (Class 1). | electron microscopy | L | 3PE, CDL | 7 (best 0.84) |
| 8CA3 | Cryo-EM structure NDUFS4 knockout complex I from Mus musculus heart (Class 2). | electron microscopy | L | 3PE, CDL | 7 (best 0.89) |
| 8IAQ | Respiratory complex Membrane domain of CI, focused map of type I, Wild type mouse under… | electron microscopy | L | 3PE, PC1, CDL | 11 (best 0.87) |
| 8IB4 | Respiratory complex CI:CIII2, type IA, Wild type mouse under cold temperature | electron microscopy | L | 3PE, CDL, EHZ | 4 (best 0.87) |
| 8IB6 | Respiratory complex Membrane domain of CI, focus-refined of type IA, Wild type mouse under cold… | electron microscopy | L | 3PE, CDL, EHZ | 13 (best 0.87) |
| 8IB9 | Respiratory complex CI:CIII2, type IB, Wild type mouse under cold temperature | electron microscopy | L | 3PE, CDL, PC1 | 3 (best 0.87) |
| 8IBB | Respiratory complex Membrane domain of CI, focus-refined of type IB, Wild type mouse under cold… | electron microscopy | L | 3PE, CDL, PC1 | 11 (best 0.87) |
| 8IBD | Respiratory complex CI:CIII2, type II, Wild type mouse under cold temperature | electron microscopy | L | 3PE, CDL, EHZ | 4 (best 0.86) |
| 8IBF | Respiratory complex Membrane domain of CI, focus-refined of type II, Wild type mouse under cold… | electron microscopy | L | 3PE, CDL, EHZ | 11 (best 0.86) |
| 8IC2 | Respiratory complex CI:CIII2, type I, PERK -/- mouse under cold temperature | electron microscopy | L | 3PE, CDL, ZN | 3 (best 0.87) |
| 8IC4 | Respiratory complex Membrane domain of CI, focus-refined of type I, PERK -/- mouse under cold… | electron microscopy | L | 3PE, CDL, ZN | 11 (best 0.87) |
| 8OM1 | Mitochondrial complex I from Mus musculus in the active state | electron microscopy | L | CDL, 3PE, PC1, MYR | 6 (best 0.84) |
| 8PW6 | C respirasome from murine liver | electron microscopy | L1 | 3PE, CDL, PC1 | 2 (best 0.84) |
| 8PW7 | A respirasome from murine liver | electron microscopy | L1 | CDL, 3PE, PC1 | 3 (best 0.83) |
| 8RGP | Closed Complex I from murine brain | electron microscopy | L | 3PE, CDL, PC1 | 7 (best 0.90) |
| 8RGQ | Open Complex I from murine liver | electron microscopy | L | 3PE, CDL, PC1 | 7 (best 0.85) |
| 8RGR | Closed Complex I from murine liver | electron microscopy | L | 3PE, CDL, PC1 | 5 (best 0.86) |
| P03921 | AlphaFold monomer V2.0 prediction for NADH-ubiquinone oxidoreductase chain 5 (P03921) | — | — | — |
Ligands
- 3PE · 1,2-diacyl-sn-glycero-3-phosphoethanolamine · in 29 records
- CDL · Cardiolipin · in 29 records
- PC1 · 1,2-diacyl-sn-glycero-3-phosphocholine · in 9 records
- EHZ · ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate · in 7 records
- ZN · Zinc ion · in 2 records
- MYR · Myristic acid · in 1 record
Elsewhere
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