UniProt Q9D6J5
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial (Q9D6J5)
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial (UniProt Q9D6J5): 14 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 27 pockets. Binding sites, druggability and experiment…
- UniProt
- Q9D6J5
- Protein
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial
- Experimental structures
- 14
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 27 · 6 records with a druggable one
Structures
15 records of Q9D6J5 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6G2J | Mouse mitochondrial complex I in the active state | electron microscopy | l | 3PE | 4 (best 0.88) |
| 6G2J | Mouse mitochondrial complex I in the active state | electron microscopy | l | 3PE | — |
| 6G72 | Mouse mitochondrial complex I in the deactive state | electron microscopy | l | — | — |
| 6ZR2 | Cryo-EM structure of respiratory complex I in the active state from mus musculus at 3.1 a | electron microscopy | l | 3PE | — |
| 6ZTQ | Cryo-EM structure of respiratory complex I from mus musculus inhibited by piericidin a at 3.0 a | electron microscopy | l | 3PE | — |
| 7AK5 | Cryo-EM structure of respiratory complex I in the deactive state from Mus musculus at 3.2 A | electron microscopy | l | 3PE | — |
| 7AK5 | Cryo-EM structure of respiratory complex I in the deactive state from mus musculus at 3.2 a | electron microscopy | l | 3PE | — |
| 7AK6 | Cryo-EM structure of ND6-P25L mutant respiratory complex I from mus musculus at 3.8 a | electron microscopy | l | 3PE | — |
| 7B93 | Cryo-EM structure of mitochondrial complex I from mus musculus inhibited by iacs-2858 at 3.0 a | electron microscopy | l | 3PE | — |
| 8IAQ | Respiratory complex Membrane domain of CI, focused map of type I, Wild type mouse under… | electron microscopy | l | 3PE, PC1 | 4 (best 0.87) |
| 8IBD | Respiratory complex CI:CIII2, type II, Wild type mouse under cold temperature | electron microscopy | l | 3PE | 3 (best 0.86) |
| 8IC4 | Respiratory complex Membrane domain of CI, focus-refined of type I, PERK -/- mouse under cold… | electron microscopy | l | 3PE | 7 (best 0.87) |
| 8PW6 | C respirasome from murine liver | electron microscopy | l1 | 3PE | 3 (best 0.88) |
| 8RGR | Closed Complex I from murine liver | electron microscopy | l | 3PE | 4 (best 0.88) |
| Q9D6J5 | AlphaFold monomer V2.0 prediction for NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8… | predicted | A | — | 2 (best 0.42) |
Ligands
Experiment against prediction
- 8RGR chain l against the predicted model Q9D6J5: TM-score 0.97, RMSD 0.81 Å
- 8PW6 chain l1 against the predicted model Q9D6J5: TM-score 0.97, RMSD 0.81 Å
- 8IC4 chain l against the predicted model Q9D6J5: TM-score 0.97, RMSD 0.84 Å
- 8IBD chain l against the predicted model Q9D6J5: TM-score 0.97, RMSD 0.85 Å
- 8IAQ chain l against the predicted model Q9D6J5: TM-score 0.97, RMSD 0.86 Å
- 7B93 chain l against the predicted model Q9D6J5: TM-score 0.97, RMSD 0.91 Å
- 6ZR2 chain l against the predicted model Q9D6J5: TM-score 0.96, RMSD 0.91 Å
- 7AK5 chain l against the predicted model Q9D6J5: TM-score 0.96, RMSD 0.94 Å
- 7AK5 chain l against the predicted model Q9D6J5: TM-score 0.96, RMSD 0.94 Å
- 6ZTQ chain l against the predicted model Q9D6J5: TM-score 0.96, RMSD 0.97 Å
Elsewhere
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