UniProt P03911
NADH-ubiquinone oxidoreductase chain 4 (P03911)
NADH-ubiquinone oxidoreductase chain 4 (UniProt P03911), EC 1.6.5.3, 7.1.1.2: 14 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 54 pockets. Binding sites, druggability and experiment against…
- UniProt
- P03911
- Protein
- NADH-ubiquinone oxidoreductase chain 4
- EC
- 1.6.5.3, 7.1.1.2
- Experimental structures
- 14
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 54 · 7 records with a druggable one
Structures
15 records of P03911 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6G2J | Mouse mitochondrial complex I in the active state | electron microscopy | M | 3PE, CDL | 8 (best 0.88) |
| 6G2J | Mouse mitochondrial complex I in the active state | electron microscopy | M | CDL, 3PE | — |
| 6G72 | Mouse mitochondrial complex I in the deactive state | electron microscopy | M | — | — |
| 6ZR2 | Cryo-EM structure of respiratory complex I in the active state from mus musculus at 3.1 a | electron microscopy | M | 3PE, CDL | — |
| 6ZTQ | Cryo-EM structure of respiratory complex I from mus musculus inhibited by piericidin a at 3.0 a | electron microscopy | M | CDL, 3PE | — |
| 7AK5 | Cryo-EM structure of respiratory complex I in the deactive state from Mus musculus at 3.2 A | electron microscopy | M | 3PE, CDL | — |
| 7AK5 | Cryo-EM structure of respiratory complex I in the deactive state from mus musculus at 3.2 a | electron microscopy | M | 3PE, CDL | — |
| 7AK6 | Cryo-EM structure of ND6-P25L mutant respiratory complex I from mus musculus at 3.8 a | electron microscopy | M | 3PE, CDL | — |
| 7B93 | Cryo-EM structure of mitochondrial complex I from mus musculus inhibited by iacs-2858 at 3.0 a | electron microscopy | M | 3PE, CDL | — |
| 8IAQ | Respiratory complex Membrane domain of CI, focused map of type I, Wild type mouse under… | electron microscopy | M | 3PE, CDL | 12 (best 0.85) |
| 8IBD | Respiratory complex CI:CIII2, type II, Wild type mouse under cold temperature | electron microscopy | M | 3PE, CDL | 6 (best 0.86) |
| 8IC4 | Respiratory complex Membrane domain of CI, focus-refined of type I, PERK -/- mouse under cold… | electron microscopy | M | 3PE, CDL | 11 (best 0.86) |
| 8PW6 | C respirasome from murine liver | electron microscopy | M1 | 3PE, CDL, PC1 | 5 (best 0.88) |
| 8RGR | Closed Complex I from murine liver | electron microscopy | M | 3PE, CDL, PC1 | 7 (best 0.88) |
| P03911 | AlphaFold monomer V2.0 prediction for NADH-ubiquinone oxidoreductase chain 4 (P03911) | predicted | A | — | 5 (best 0.58) |
Ligands
Experiment against prediction
- 8RGR chain M against the predicted model P03911: TM-score 0.99, RMSD 0.64 Å
- 8PW6 chain M1 against the predicted model P03911: TM-score 0.99, RMSD 0.65 Å
- 7B93 chain M against the predicted model P03911: TM-score 0.99, RMSD 0.66 Å
- 6ZTQ chain M against the predicted model P03911: TM-score 0.99, RMSD 0.71 Å
- 6ZR2 chain M against the predicted model P03911: TM-score 0.99, RMSD 0.73 Å
- 7AK5 chain M against the predicted model P03911: TM-score 0.99, RMSD 0.73 Å
- 7AK5 chain M against the predicted model P03911: TM-score 0.99, RMSD 0.73 Å
- 8IAQ chain M against the predicted model P03911: TM-score 0.99, RMSD 0.74 Å
- 8IBD chain M against the predicted model P03911: TM-score 0.99, RMSD 0.75 Å
- 8IC4 chain M against the predicted model P03911: TM-score 0.99, RMSD 0.75 Å
Elsewhere
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