MolNFT v1 · #273314 · protein
AlphaFold monomer V2.0 prediction for NADH-ubiquinone oxidoreductase chain 4 (P03911)
P03911: “AlphaFold monomer V2.0 prediction for NADH-ubiquinone oxidoreductase chain 4 (P03911)”. 5 pockets (best druggability 0.58). MolNFT v1 #273314 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P03911
- Type
- protein
- Length
- 459 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x9073C46348542FfE4327c3F363F9B51B22058e75
- Molecule
- NADH-ubiquinone oxidoreductase chain 4
- UniProt
- P03911
- Pockets
- 5 · best druggability 0.58
Structure
1 distinct chain · 76% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | NADH-ubiquinone oxidoreductase chain 4 | protein | 459 | 76% helix, 3% strand | P03911 |
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 140 | 0.58 | 0.82 | 20 | empty |
| 2 | 223 | 0.55 | 0.78 | 30 | empty |
| 3 | 89 | 0.41 | 0.79 | 21 | empty |
| 4 | 58 | 0.36 | 0.78 | 13 | empty |
| 5 | 54 | 0.35 | 0.78 | 11 | empty |
Compared structures
- 8RGR · Closed Complex I from murine liver · an experimental structure of the same protein · chain A against M, TM-score 0.99
- 8PW6 · C respirasome from murine liver · an experimental structure of the same protein · chain A against M1, TM-score 0.99
- 7B93 · Cryo-EM structure of mitochondrial complex I from mus musculus inhibited by iacs-2858 at… · an experimental structure of the same protein · chain A against M, TM-score 0.99
- 6ZTQ · Cryo-EM structure of respiratory complex I from mus musculus inhibited by piericidin a at… · an experimental structure of the same protein · chain A against M, TM-score 0.99
- 6ZR2 · Cryo-EM structure of respiratory complex I in the active state from mus musculus at 3.1 a · an experimental structure of the same protein · chain A against M, TM-score 0.99
- 7AK5 · Cryo-EM structure of respiratory complex I in the deactive state from Mus musculus at 3.2… · an experimental structure of the same protein · chain A against M, TM-score 0.99
- 7AK5 · Cryo-EM structure of respiratory complex I in the deactive state from mus musculus at 3.2… · an experimental structure of the same protein · chain A against M, TM-score 0.99
- 8IAQ · Respiratory complex Membrane domain of CI, focused map of type I, Wild type mouse under… · an experimental structure of the same protein · chain A against M, TM-score 0.99
- 8IBD · Respiratory complex CI:CIII2, type II, Wild type mouse under cold temperature · an experimental structure of the same protein · chain A against M, TM-score 0.99
- 8IC4 · Respiratory complex Membrane domain of CI, focus-refined of type I, PERK -/- mouse under… · an experimental structure of the same protein · chain A against M, TM-score 0.99
- 6G2J · Mouse mitochondrial complex I in the active state · an experimental structure of the same protein · chain A against M, TM-score 0.99
- 6G2J · Mouse mitochondrial complex I in the active state · an experimental structure of the same protein · chain A against M, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03911
- Elsewhere: UniProt P03911 · AlphaFold DB P03911
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