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Cryo-EM structure of respiratory complex I in the deactive state from mus musculus at 3.2 a

Analyse Cryo-EM structure of respiratory complex I in the deactive state from mus… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
7AK5
Type
protein
Length
8,069 residues
Chains
45
Method
electron microscopy
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt
P03899, Q9DC70, Q9DCT2, Q91WD5, Q9D6J6, Q91YT0, Q91VD9, P03888, Q8K3J1, P03925, P03903, P03921, P03911, P03893, Q99LC3, Q9DC69, Q9CXZ1, P52503, Q9CQ75, Q9CR21, Q9CPP6, Q9CQZ5, Q9DCJ5, G5E814, Q9ERS2, O35683, Q9CQ91, Q9CQY9, Q9CQ54, Q99LY9, P0DN34, O09111, Q9CQH3, Q3UIU2, Q9CPU2, Q9CQZ6, Q9D6J5, Q9CQC7, Q9CQJ8, Q9CR61, Q9DCS9, Q7TMF3, Q9Z1P6, Q8BK30
Ligands
3PE, SF4, CDL, PC1, FES, EHZ, FMN, ATP, NDP, ZN

Structure

electron microscopy · 45 distinct chains.

ChainMoleculeTypeResiduesSecondary structureUniProt
A—protein90—P03899
B—protein155—Q9DC70
C—protein206—Q9DCT2
D—protein419—Q91WD5
E—protein210—Q9D6J6
F—protein428—Q91YT0
G—protein687—Q91VD9
H—protein308—P03888
I—protein178—Q8K3J1
J—protein171—P03925
K—protein98—P03903
L—protein606—P03921
M—protein459—P03911
N—protein344—P03893
O—protein320—Q99LC3
P—protein290—Q9DC69
Q—protein125—Q9CXZ1
R—protein94—P52503
S—protein82—Q9CQ75
T—protein73—Q9CR21
U—protein88—Q9CR21
V—protein112—Q9CPP6
W—protein114—Q9CQZ5
X—protein171—Q9DCJ5
Y—protein140—G5E814
Z—protein139—Q9ERS2
a—protein68—O35683
b—protein83—Q9CQ91
c—protein46—Q9CQY9
d—protein119—Q9CQ54
e—protein104—Q99LY9
f—protein50—P0DN34
g—protein101—O09111
h—protein137—Q9CQH3
i—protein96—Q3UIU2
j—protein63—Q9CPU2
k—protein78—Q9CQZ6
l—protein156—Q9D6J5
m—protein125—Q9CQC7
n—protein176—Q9CQJ8
o—protein114—Q9CR61
p—protein168—Q9DCS9
q—protein143—Q7TMF3
r—protein96—Q9Z1P6
s—protein39—Q8BK30

Ligands and binding sites

  • 3PE · 1,2-diacyl-sn-glycero-3-phosphoethanolamine · ligand · 8 copies · chains A, H, J, Z, a, D, I, b, L, M, l, N, Y, g, O, d, f, h, i
  • SF4 · Iron/sulfur cluster · ligand · 6 copies · chains B, D, F, G, I
  • CDL · Cardiolipin · ligand · 4 copies · chains L, M, g, h, N, X, d, f, i, p, H, I, a, q, r
  • PC1 · 1,2-diacyl-sn-glycero-3-phosphocholine · ligand · 2 copies · chains B, H, q, I, Z, r
  • FES · Fe2/s2 (inorganic) cluster · ligand · 2 copies · chains E, G
  • EHZ · ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate · ligand · 2 copies · chains T, W, U, n
  • FMN · Flavin mononucleotide · ligand · chains F
  • ATP · Adenosine-5'-triphosphate · ligand · chains O
  • NDP · Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate · ligand · chains B, P
  • ZN · Zinc ion · metal · chains R

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

  • 7AK5 · Cryo-EM structure of respiratory complex I in the deactive state from Mus musculus at 3.2… · the same entry in another collection · chain e against e, TM-score 1.00

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