GL1X · GenesisL1 explorer

MolNFT v2 · #160440 · protein + RNA

Structure of human ribosome nascent chain complex selectively stalled by a drug-like small molecule (USO1-RNC)

6OLI: “Structure of human ribosome nascent chain complex selectively stalled by a drug-like small molecule (USO1-RNC)”. Electron microscopy at 3.5, 3 ligands (MVM, MG, ZN). MolNFT v2 #160440 on GenesisL1: 3D structure, binding sites and…

PDB
6OLI
Type
protein + RNA
Length
17,147 residues
Chains
83
Method
electron microscopy
Collection
MolNFT v2 / PDB Bank
Contract
0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner
0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution
3.5
Source
Homo sapiens
UniProt
P08865, P61247, P23396, P62701, P46782, P62081, P62241, P46783, P62280, P62841, P62249, P08708, P62269, P39019, P60866, P63220, P62266, P62854, P62857, P62273, P63244, P15880, P62753, P46781, P25398, P62277, P62263, P62244, P62847, P62851, P42677, E9PR30, P62979, P62917, P39023, P36578, P46777, Q02878, P18124, P62424, P32969, P27635, P62913, P26373, P50914, P61313, P40429, P18621, Q07020, P84098, Q02543, P46778, P35268, Q9BTQ7, P83731, P62750, P61254, P61353, P46776, P47914, P62888, P62899, P62910, P18077, P49207, P42766, Q9Y3U8, P61927, P63173, P62891, P62987, P62945, P83881, P61513, P46779
Ligands
MVM, MG, ZN

Structure

electron microscopy · resolution 3.5 · 83 distinct chains.

ChainMoleculeTypeResiduesSecondary structureUniProt
S2—rna1714——
SA—protein221—P08865
SB—protein214—P61247
SD—protein226—P23396
SE—protein259—P62701
SF—protein189—P46782
SH—protein186—P62081
SI—protein204—P62241
SK—protein98—P46783
SL—protein153—P62280
SP—protein127—P62841
SQ—protein146—P62249
SR—protein134—P08708
SS—protein145—P62269
ST—protein143—P39019
SU—protein104—P60866
SV—protein82—P63220
SX—protein141—P62266
Sa—protein102—P62854
Sc—protein64—P62857
Sd—protein55—P62273
Sg—protein312—P63244
SC—protein220—P15880
SG—protein237—P62753
SJ—protein185—P46781
SM—protein118—P25398
SN—protein150—P62277
SO—protein137—P62263
SW—protein129—P62244
SY—protein131—P62847
SZ—protein73—P62851
Sb—protein82—P42677
Se—protein57—E9PR30
Sf—protein67—P62979
A—protein252—P62917
B—protein397—P39023
C—protein363—P36578
D—rna157——
E—rna119——
F—protein294—P46777
G—protein236—Q02878
H—protein225—P18124
I—protein234—P62424
J—protein191—P32969
K—protein208—P27635
L—protein169—P62913
M—protein205—P26373
N—protein139—P50914
O—protein203—P61313
P—protein195—P40429
Q—protein153—P18621
R—protein187—Q07020
S—protein181—P84098
T—protein175—Q02543
U—protein157—P46778
V—protein99—P35268
W—protein129—Q9BTQ7
X—protein61—P83731
Y—protein117—P62750
Z—protein134—P61254
a—protein134—P61353
b—protein147—P46776
c—protein100—P47914
d—protein103—P62888
e—protein106—P62899
f—protein129—P62910
g—protein109—P18077
h—protein114—P49207
i—protein122—P42766
j—protein97—Q9Y3U8
k—protein84—P61927
l—protein69—P63173
m—protein50—P62891
n—protein50—P62987
o—protein25—P62945
p—protein105—P83881
q—protein91—P61513
r—protein122—P46779
t—rna3607——
u—rna76——
v—rna76——
w—rna10——
y—protein36——

Ligands and binding sites

  • MVM · N-(3-chloropyridin-2-yl)-N-[(3R)-piperidin-3-yl]-4-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)benzamide · ligand · chains t, y
  • MG · Magnesium ion · metal · 31 copies · chains S2, B, D, t, E, O, b, o, A, Z, f
  • ZN · Zinc ion · metal · 6 copies · chains S2, Sa, Sf, k, p, q

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

  • P62701 · AlphaFold monomer V2.0 prediction for 40S ribosomal protein S4, X isoform (P62701) · a predicted model of the same protein · chain SE against A, TM-score 0.99
  • P39023 · AlphaFold monomer V2.0 prediction for 60S ribosomal protein L3 (P39023) · a predicted model of the same protein · chain B against A, TM-score 0.99
  • P61313 · AlphaFold monomer V2.0 prediction for 60S ribosomal protein L15 (P61313) · a predicted model of the same protein · chain O against A, TM-score 0.99
  • P18621 · AlphaFold monomer V2.0 prediction for 60S ribosomal protein L17 (P18621) · a predicted model of the same protein · chain Q against A, TM-score 0.99
  • P62917 · AlphaFold monomer V2.0 prediction for 60S ribosomal protein L8 (P62917) · a predicted model of the same protein · chain A against A, TM-score 0.99
  • P40429 · AlphaFold monomer V2.0 prediction for 60S ribosomal protein L13A (P40429) · a predicted model of the same protein · chain P against A, TM-score 0.98
  • P62913 · AlphaFold monomer V2.0 prediction for 60S ribosomal protein L11 (P62913) · a predicted model of the same protein · chain L against A, TM-score 0.98
  • Q07020 · AlphaFold monomer V2.0 prediction for 60S ribosomal protein L18 (Q07020) · a predicted model of the same protein · chain R against A, TM-score 0.98
  • P62244 · AlphaFold monomer V2.0 prediction for 40S ribosomal protein S15A (P62244) · a predicted model of the same protein · chain SW against A, TM-score 0.98
  • P36578 · AlphaFold monomer V2.0 prediction for 60S ribosomal protein L4 (P36578) · a predicted model of the same protein · chain C against A, TM-score 0.98
  • P62277 · AlphaFold monomer V2.0 prediction for 40S ribosomal protein S13 (P62277) · a predicted model of the same protein · chain SN against A, TM-score 0.98
  • P61254 · AlphaFold monomer V2.0 prediction for 60S ribosomal protein L26 (P61254) · a predicted model of the same protein · chain Z against A, TM-score 0.98

Analyse

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.