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UniProt P25398

40S ribosomal protein S12 (P25398)

40S ribosomal protein S12 (UniProt P25398): 41 experimental structures and 1 predicted model on GenesisL1, 2 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.

UniProt
P25398
Protein
40S ribosomal protein S12
Experimental structures
41
Predicted models
1
Pockets
2 · 2 records with a druggable one

Structures

42 records of P25398 in the MolNFT archive: 41 experimental, 1 predicted.

EntryTitleMethodChainsLigandsPockets
4V6XStructure of the human 80S ribosomeelectron microscopyAM——
5A2QStructure of the HCV ires bound to the human ribosomeelectron microscopyM——
5FLXMammalian 40S HCV-ires complexelectron microscopyM——
5LKSStructure-function insights reveal the human ribosome as a cancer target for antibioticselectron microscopySM——
5OA3Human 40S-EIF2D-re-initiation complexelectron microscopyM——
6G18Cryo-EM structure of a late human pre-40S ribosomal subunit - state Celectron microscopyM——
6G51Cryo-EM structure of a late human pre-40S ribosomal subunit - state Delectron microscopyM——
6G53Cryo-EM structure of a late human pre-40S ribosomal subunit - state Eelectron microscopyM——
6G5HCryo-EM structure of a late human pre-40S ribosomal subunit - matureelectron microscopyM——
6G5ICryo-EM structure of a late human pre-40S ribosomal subunit - state Relectron microscopyM——
6IP8Cryo-EM structure of the HCV IRES dependently initiated CMV-stalled 80S ribosome (Structure iv)electron microscopy3J——
6OLEHuman ribosome nascent chain complex (CDH1-RNC) stalled by a drug-like molecule with AP and PE tRNAselectron microscopySM——
6OLIStructure of human ribosome nascent chain complex selectively stalled by a drug-like small molecule…electron microscopySM——
6YBSStructure of a human 48S translational initiation complex - headelectron microscopym——
6ZLWSARS-cov-2 NSP1 bound to the human 40S ribosomal subunitelectron microscopyO——
6ZMTSARS-cov-2 NSP1 bound to a pre-40S-like ribosome complexelectron microscopyO——
6ZN5SARS-cov-2 NSP1 bound to a pre-40S-like ribosome complex - state 2electron microscopyO——
6ZOJSARS-CoV-2-Nsp1-40S complex, composite mapelectron microscopyM——
6ZOJSARS-cov-2-NSP1-40S complex, composite MAPelectron microscopyM——
6ZOLSARS-cov-2-NSP1-40S complex, focused on headelectron microscopyM——
6ZUOHuman RIO1(KD)-stha late pre-40S particle, structural state a (pre 18S rRNA cleavage)electron microscopyM——
6ZV6Human RIO1(kd)-StHA late pre-40S particle, structural state B (post 18S rRNA cleavage)electron microscopyM——
6ZV6Human RIO1(KD)-stha late pre-40S particle, structural state B (post 18S rRNA cleavage)electron microscopyM——
6ZVHEDF1-ribosome complexelectron microscopyM——
6ZXDCryo-EM structure of a late human pre-40S ribosomal subunit - state F1electron microscopyM——
6ZXECryo-EM structure of a late human pre-40S ribosomal subunit - state F2electron microscopyM——
6ZXFCryo-EM structure of a late human pre-40S ribosomal subunit - state Gelectron microscopyM——
6ZXGCryo-EM structure of a late human pre-40S ribosomal subunit - state H1electron microscopyM——
6ZXHCryo-EM structure of a late human pre-40S ribosomal subunit - state H2electron microscopyM——
7A09Structure of a human ABCE1-bound 43S pre-initiation complex - State IIIelectron microscopyv——
7K5ISARS-cov-2 NSP1 in complex with human 40S ribosomeelectron microscopyM——
7WTWCryo-EM structure of a human pre-40S ribosomal subunit - State RRP12-A3electron microscopyM—1 (best 0.85)
7WTXCryo-EM structure of a human pre-40S ribosomal subunit - State RRP12-B1electron microscopyM——
7XNXHigh resolution cry-EM structure of the human 80S ribosome from SNORD127+/+ Kasumi-1 cellselectron microscopySM——
7XNYHigh resolution cry-EM structure of the human 80S ribosome from SNORD127+/- Kasumi-1 cellselectron microscopySM——
8G5YmRNA decoding in human is kinetically and structurally distinct from bacteria (IC state)electron microscopySM——
8G61mRNA decoding in human is kinetically and structurally distinct from bacteria (AC state)electron microscopySM——
8K2CCryo-EM structure of the human 80S ribosome with Tigecyclineelectron microscopySM——
8PPKBat-Hp-CoV Nsp1 and eIF1 bound to the human 40S small ribosomal subunitelectron microscopyM——
8PPLMERS-CoV Nsp1 bound to the human 43S pre-initiation complexelectron microscopyAM—1 (best 0.85)
9G8Mhuman 80S ribosome bound by a SKI2-exosome complexelectron microscopySM——
P25398AlphaFold monomer V2.0 prediction for 40S ribosomal protein S12 (P25398)predictedA——

Experiment against prediction

Elsewhere

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