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Ligand · MVM

MVM · N-(3-chloropyridin-2-yl)-N-[(3R)-piperidin-3-yl]-4-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)benzamide

MVM, N-(3-chloropyridin-2-yl)-N-[(3R)-piperidin-3-yl]-4-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)benzamide (C22 H20 Cl N7 O, 433.9 g/mol), in the MolNFT structures on GenesisL1: bound in 8 records (8 PDB entries). Every binding site with its…

Component
MVM
Formula
C22 H20 Cl N7 O
Class
ligand
Structures
8
PDB entries
8

Binding sites

MVM in 8 structures; the first of them:

  • 6OLE · Human ribosome nascent chain complex (CDH1-RNC) stalled by a drug-like molecule with AP… · MVM y101 · binds HIS133, A1575, C1576, G1577, G1579, A1583, U1584, G3875 and 7 more
  • 6OLF · Human ribosome nascent chain complex (CDH1-RNC) stalled by a drug-like molecule with AA… · MVM t5112 · binds HIS133, A1575, C1576, G1577, G1579, A1583, U1584, G3875 and 6 more
  • 6OLG · Human ribosome nascent chain complex stalled by a drug-like small molecule (CDH1_RNC with… · MVM A25327 · binds HIS133, A1575, C1576, G1577, G1579, A1583, U1584, G3875 and 5 more
  • 6OLI · Structure of human ribosome nascent chain complex selectively stalled by a drug-like… · MVM t5110 · binds HIS133, A1575, C1576, G1577, G1579, A1583, U1584, G3875 and 6 more
  • 6OLZ · Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like molecule with PP… · MVM A101 · binds HIS133, A1575, C1576, G1577, U1578, G1579, A1583, U1584 and 6 more
  • 6OM0 · Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like molecule with AP… · MVM t5110 · binds HIS133, A1575, C1576, G1577, G1579, A1583, U1584, G3875 and 9 more
  • 6OM7 · Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like small molecule… · MVM t5112 · binds HIS133, A1575, C1576, G1577, G1579, A1583, U1584, G3875 and 5 more
  • 6XA1 · Structure of a drug-like compound stalled human translation termination complex · MVM L55246 · binds A1580, C1581, G1582, G1584, A1588, U1589, G3883, U4525 and 7 more

Residues it binds most

U 8, G 8, A 8, LEU 5, C 8, HIS 8, ALA 3, GLY 3, ILE 3, UNK 1 (residue and the binding sites it lines).

Found with

  • MG · Magnesium ion
  • ZN · Zinc ion
  • K · Potassium ion

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