UniProt P62241
40S ribosomal protein S8 (P62241)
40S ribosomal protein S8 (UniProt P62241): 92 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 85 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P62241
- Protein
- 40S ribosomal protein S8
- Experimental structures
- 92
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 85 · 47 records with a druggable one
Structures
93 records of P62241 in the MolNFT archive: 92 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4UG0 | Structure of the human 80S ribosome | electron microscopy | SI | — | — |
| 4V6X | Structure of the human 80S ribosome | electron microscopy | AI | — | — |
| 5A2Q | Structure of the HCV IRES bound to the human ribosome | electron microscopy | I | MG | 1 (best 0.83) |
| 5A2Q | Structure of the HCV ires bound to the human ribosome | electron microscopy | I | — | — |
| 5FLX | Mammalian 40S HCV-IRES complex | electron microscopy | I | MG | 2 (best 0.85) |
| 5FLX | Mammalian 40S HCV-ires complex | electron microscopy | I | — | — |
| 5LKS | Structure-function insights reveal the human ribosome as a cancer target for antibiotics | electron microscopy | SI | MG | — |
| 5OA3 | Human 40S-EIF2D-re-initiation complex | electron microscopy | I | — | — |
| 5VYC | Crystal structure of the human 40S ribosomal subunit in complex with DENR-MCT-1. | x-ray diffraction | I1, I2, I3, I4, I5, I6 | — | 4 (best 0.88) |
| 6G18 | Cryo-EM structure of a late human pre-40S ribosomal subunit - state C | electron microscopy | I | — | — |
| 6G4S | Cryo-EM structure of a late human pre-40S ribosomal subunit - State B | electron microscopy | I | — | 1 (best 0.78) |
| 6G4S | Cryo-EM structure of a late human pre-40S ribosomal subunit - state B | electron microscopy | I | — | — |
| 6G4W | Cryo-EM structure of a late human pre-40S ribosomal subunit - state a | electron microscopy | I | — | — |
| 6G51 | Cryo-EM structure of a late human pre-40S ribosomal subunit - state D | electron microscopy | I | — | — |
| 6G53 | Cryo-EM structure of a late human pre-40S ribosomal subunit - state E | electron microscopy | I | — | — |
| 6G5H | Cryo-EM structure of a late human pre-40S ribosomal subunit - Mature | electron microscopy | I | — | 3 (best 0.88) |
| 6G5H | Cryo-EM structure of a late human pre-40S ribosomal subunit - mature | electron microscopy | I | — | — |
| 6G5I | Cryo-EM structure of a late human pre-40S ribosomal subunit - state R | electron microscopy | I | — | — |
| 6IP8 | Cryo-EM structure of the HCV IRES dependently initiated CMV-stalled 80S ribosome (Structure iv) | electron microscopy | 2t | — | — |
| 6OLE | Human ribosome nascent chain complex (CDH1-RNC) stalled by a drug-like molecule with AP and PE tRNAs | electron microscopy | SI | — | — |
| 6OLF | Human ribosome nascent chain complex (CDH1-RNC) stalled by a drug-like molecule with AA and PE tRNAs | electron microscopy | SI | — | — |
| 6OLI | Structure of human ribosome nascent chain complex selectively stalled by a drug-like small molecule… | electron microscopy | SI | — | — |
| 6OM0 | Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like molecule with AP and PE… | electron microscopy | SI | — | — |
| 6OM7 | Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like small molecule with AA and… | electron microscopy | SI | — | 1 (best 0.88) |
| 6QZP | High-resolution cryo-EM structure of the human 80S ribosome | electron microscopy | SI | — | 2 (best 0.88) |
| 6XA1 | Structure of a drug-like compound stalled human translation termination complex | electron microscopy | SI | MG | 1 (best 0.89) |
| 6YBW | Structure of a human 48S translational initiation complex - 40S body | electron microscopy | R | MG | 2 (best 0.86) |
| 6YBW | Structure of a human 48S translational initiation complex - 40S body | electron microscopy | R | — | — |
| 6Z6L | Cryo-EM structure of human CCDC124 bound to 80S ribosomes | electron microscopy | SI | MG | — |
| 6ZLW | SARS-cov-2 NSP1 bound to the human 40S ribosomal subunit | electron microscopy | I | — | — |
| 6ZMO | SARS-CoV-2 Nsp1 bound to the human LYAR-80S-eEF1a ribosome complex | electron microscopy | SI | — | 2 (best 0.88) |
| 6ZMT | SARS-CoV-2 Nsp1 bound to a pre-40S-like ribosome complex | electron microscopy | I | — | 3 (best 0.88) |
| 6ZMT | SARS-cov-2 NSP1 bound to a pre-40S-like ribosome complex | electron microscopy | I | — | — |
| 6ZN5 | SARS-cov-2 NSP1 bound to a pre-40S-like ribosome complex - state 2 | electron microscopy | I | — | — |
| 6ZOJ | SARS-CoV-2-Nsp1-40S complex, composite map | electron microscopy | I | MG | — |
| 6ZOJ | SARS-cov-2-NSP1-40S complex, composite MAP | electron microscopy | I | MG | — |
| 6ZOK | SARS-cov-2-NSP1-40S complex, focused on body | electron microscopy | I | MG | — |
| 6ZON | SARS-CoV-2 Nsp1 bound to a human 43S preinitiation ribosome complex - state 1 | electron microscopy | t | — | — |
| 6ZUO | Human RIO1(KD)-stha late pre-40S particle, structural state a (pre 18S rRNA cleavage) | electron microscopy | I | — | — |
| 6ZV6 | Human RIO1(kd)-StHA late pre-40S particle, structural state B (post 18S rRNA cleavage) | electron microscopy | I | — | 2 (best 0.87) |
| 6ZV6 | Human RIO1(KD)-stha late pre-40S particle, structural state B (post 18S rRNA cleavage) | electron microscopy | I | — | — |
| 6ZVH | EDF1-ribosome complex | electron microscopy | I | MG | — |
| 6ZXD | Cryo-EM structure of a late human pre-40S ribosomal subunit - state F1 | electron microscopy | I | — | — |
| 6ZXE | Cryo-EM structure of a late human pre-40S ribosomal subunit - state F2 | electron microscopy | I | — | — |
| 6ZXF | Cryo-EM structure of a late human pre-40S ribosomal subunit - State G | electron microscopy | I | — | 2 (best 0.89) |
| 6ZXF | Cryo-EM structure of a late human pre-40S ribosomal subunit - state G | electron microscopy | I | — | — |
| 6ZXG | Cryo-EM structure of a late human pre-40S ribosomal subunit - state H1 | electron microscopy | I | MG | — |
| 6ZXH | Cryo-EM structure of a late human pre-40S ribosomal subunit - state H2 | electron microscopy | I | MG | — |
| 7A09 | Structure of a human ABCE1-bound 43S pre-initiation complex - State III | electron microscopy | t | — | — |
| 7K5I | SARS-cov-2 NSP1 in complex with human 40S ribosome | electron microscopy | I | — | — |
| 7MQA | Cryo-EM structure of the human SSU processome, state post-A1 | electron microscopy | L8 | — | — |
| 7QP6 | Structure of the human 48S initiation complex in open state (h48S AUG open) | electron microscopy | R | — | 2 (best 0.86) |
| 7QP7 | Structure of the human 48S initiation complex in closed state (h48S AUG closed) | electron microscopy | R | — | 2 (best 0.88) |
| 7QVP | Human collided disome (di-ribosome) stalled on XBP1 mRNA | electron microscopy | RI, SI | — | — |
| 7TQL | Cryoem structure of the human 40S small ribosomal subunit in complex with translation initiation… | electron microscopy | I | — | — |
| 7WTS | Cryo-EM structure of a human pre-40S ribosomal subunit - State UTP14 | electron microscopy | I | — | 2 (best 0.84) |
| 7WTT | Cryo-EM structure of a human pre-40S ribosomal subunit - State RRP12-A1 (with CK1) | electron microscopy | I | — | 2 (best 0.88) |
| 7WTW | Cryo-EM structure of a human pre-40S ribosomal subunit - State RRP12-A3 | electron microscopy | I | — | 2 (best 0.88) |
| 7WTX | Cryo-EM structure of a human pre-40S ribosomal subunit - State RRP12-B1 | electron microscopy | I | — | 2 (best 0.85) |
| 7WTZ | Cryo-EM structure of a human pre-40S ribosomal subunit - State RRP12-B2 | electron microscopy | I | — | 3 (best 0.88) |
33 records more on the page itself.
Ligands
Experiment against prediction
- 8PJ6 chain R against the predicted model P62241: TM-score 0.98, RMSD 0.87 Å
- 6XA1 chain SI against the predicted model P62241: TM-score 0.97, RMSD 0.89 Å
- 7QP6 chain R against the predicted model P62241: TM-score 0.97, RMSD 0.90 Å
- 8PJ1 chain R against the predicted model P62241: TM-score 0.97, RMSD 0.91 Å
- 6YBW chain R against the predicted model P62241: TM-score 0.97, RMSD 0.92 Å
- 6YBW chain R against the predicted model P62241: TM-score 0.97, RMSD 0.92 Å
- 7A09 chain t against the predicted model P62241: TM-score 0.97, RMSD 0.90 Å
- 6ZON chain t against the predicted model P62241: TM-score 0.97, RMSD 0.93 Å
- 6ZXG chain I against the predicted model P62241: TM-score 0.97, RMSD 1.00 Å
- 6ZXH chain I against the predicted model P62241: TM-score 0.97, RMSD 1.02 Å
Elsewhere
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