UniProt P46778
60S ribosomal protein L21 (P46778)
60S ribosomal protein L21 (UniProt P46778): 83 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 84 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P46778
- Protein
- 60S ribosomal protein L21
- Experimental structures
- 83
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 84 · 59 records with a druggable one
Structures
84 records of P46778 in the MolNFT archive: 83 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4UG0 | Structure of the human 80S ribosome | electron microscopy | LT | — | — |
| 4V6X | Structure of the human 80S ribosome | electron microscopy | CT | — | — |
| 5LKS | Structure-function insights reveal the human ribosome as a cancer target for antibiotics | electron microscopy | LT | — | — |
| 6IP8 | Cryo-EM structure of the HCV IRES dependently initiated CMV-stalled 80S ribosome (Structure iv) | electron microscopy | 2N | — | — |
| 6LQM | Cryo-EM structure of a pre-60S ribosomal subunit - state C | electron microscopy | c | — | — |
| 6LSS | Cryo-EM structure of a pre-60S ribosomal subunit - state preA | electron microscopy | c | MG | — |
| 6LU8 | Cryo-EM structure of a human pre-60S ribosomal subunit - state A | electron microscopy | c | MG | 1 (best 0.88) |
| 6OLE | Human ribosome nascent chain complex (CDH1-RNC) stalled by a drug-like molecule with AP and PE tRNAs | electron microscopy | U | — | — |
| 6OLF | Human ribosome nascent chain complex (CDH1-RNC) stalled by a drug-like molecule with AA and PE tRNAs | electron microscopy | U | — | 3 (best 0.87) |
| 6OLG | Human ribosome nascent chain complex stalled by a drug-like small molecule (CDH1_RNC with PP tRNA) | electron microscopy | AT | — | 2 (best 0.89) |
| 6OLI | Structure of human ribosome nascent chain complex selectively stalled by a drug-like small molecule… | electron microscopy | U | — | — |
| 6OM0 | Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like molecule with AP and PE… | electron microscopy | U | — | 2 (best 0.86) |
| 6OM7 | Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like small molecule with AA and… | electron microscopy | U | — | 1 (best 0.87) |
| 6QZP | High-resolution cryo-EM structure of the human 80S ribosome | electron microscopy | LT | MG | 1 (best 0.89) |
| 6W6L | Cryo-EM structure of the human ribosome-TMCO1 translocon | electron microscopy | U | — | 1 (best 0.88) |
| 6XA1 | Structure of a drug-like compound stalled human translation termination complex | electron microscopy | LT | — | 1 (best 0.87) |
| 6Y2L | Structure of human ribosome in POST state | electron microscopy | LT | — | 1 (best 0.87) |
| 6Y6X | Tetracenomycin X bound to the human ribosome | electron microscopy | LT | MG | 1 (best 0.88) |
| 6Z6L | Cryo-EM structure of human CCDC124 bound to 80S ribosomes | electron microscopy | LT | MG | 2 (best 0.89) |
| 6Z6M | Cryo-EM structure of human 80S ribosomes bound to EBP1, eEF2 and SERBP1 | electron microscopy | LT | MG | 1 (best 0.89) |
| 6ZMO | SARS-CoV-2 Nsp1 bound to the human LYAR-80S-eEF1a ribosome complex | electron microscopy | LT | MG | 2 (best 0.87) |
| 7F5S | human delta-METTL18 60S ribosome | electron microscopy | LT | MG | 3 (best 0.87) |
| 7OW7 | EIF6-bound large subunit of the human ribosome | electron microscopy | N | K | 2 (best 0.87) |
| 7QVP | Human collided disome (di-ribosome) stalled on XBP1 mRNA | electron microscopy | LT, MT | — | — |
| 7XNX | High resolution cry-EM structure of the human 80S ribosome from SNORD127+/+ Kasumi-1 cells | electron microscopy | LT | MG | 1 (best 0.87) |
| 7XNY | High resolution cry-EM structure of the human 80S ribosome from SNORD127+/- Kasumi-1 cells | electron microscopy | LT | MG | 1 (best 0.89) |
| 8A3D | Human mature large subunit of the ribosome with eIF6 and homoharringtonine bound | electron microscopy | N | MG, K | 2 (best 0.89) |
| 8FKQ | Human nucleolar pre-60S ribosomal subunit (State A2) | electron microscopy | LE | — | — |
| 8FKR | Human nucleolar pre-60S ribosomal subunit (State B1) | electron microscopy | LE | — | — |
| 8FKS | Human nucleolar pre-60S ribosomal subunit (State B2) | electron microscopy | LE | — | — |
| 8FKU | Human nucleolar pre-60S ribosomal subunit (State C2) | electron microscopy | LE | — | 1 (best 0.83) |
| 8FKV | Human nucleolar pre-60S ribosomal subunit (State D1) | electron microscopy | LE | — | — |
| 8FKW | Human nucleolar pre-60S ribosomal subunit (State D2) | electron microscopy | LE | — | — |
| 8FKX | Human nucleolar pre-60S ribosomal subunit (State E) | electron microscopy | LE | — | — |
| 8FKZ | Human nucleolar pre-60S ribosomal subunit (State G) | electron microscopy | LE | — | — |
| 8FL0 | Human nucleolar pre-60S ribosomal subunit (State H) | electron microscopy | LE | — | 1 (best 0.82) |
| 8FL2 | Human nuclear pre-60S ribosomal subunit (State I1) | electron microscopy | LE | — | 1 (best 0.85) |
| 8FL3 | Human nuclear pre-60S ribosomal subunit (State I2) | electron microscopy | LE | — | 1 (best 0.88) |
| 8FL4 | Human nuclear pre-60S ribosomal subunit (State I3) | electron microscopy | LE | — | 1 (best 0.88) |
| 8FL6 | Human nuclear pre-60S ribosomal subunit (State J1) | electron microscopy | LE | — | 1 (best 0.87) |
| 8FL7 | Human nuclear pre-60S ribosomal subunit (State J2) | electron microscopy | LE | — | 1 (best 0.87) |
| 8FL9 | Human nuclear pre-60S ribosomal subunit (State J3) | electron microscopy | LE | — | 1 (best 0.88) |
| 8FLB | Human nuclear pre-60S ribosomal subunit (State K2) | electron microscopy | LE | — | — |
| 8FLC | Human nuclear pre-60S ribosomal subunit (State K3) | electron microscopy | LE | — | 2 (best 0.87) |
| 8FLD | Human nuclear pre-60S ribosomal subunit (State L1) | electron microscopy | LE | — | — |
| 8FLE | Human nuclear pre-60S ribosomal subunit (State L2) | electron microscopy | LE | — | — |
| 8FLF | Human nuclear pre-60S ribosomal subunit (State L3) | electron microscopy | LE | — | 2 (best 0.88) |
| 8G5Y | mRNA decoding in human is kinetically and structurally distinct from bacteria (IC state) | electron microscopy | LT | K, MG | 1 (best 0.88) |
| 8G5Z | mRNA decoding in human is kinetically and structurally distinct from bacteria (GA state) | electron microscopy | LT | K | 2 (best 0.88) |
| 8G60 | mRNA decoding in human is kinetically and structurally distinct from bacteria (CR state) | electron microscopy | LT | MG | 2 (best 0.87) |
| 8G61 | mRNA decoding in human is kinetically and structurally distinct from bacteria (AC state) | electron microscopy | LT | MG | 1 (best 0.89) |
| 8GLP | mRNA decoding in human is kinetically and structurally distinct from bacteria (Consensus LSU… | electron microscopy | LT | K, MG | 1 (best 0.87) |
| 8IDT | human nuclear pre-60S ribosomal particle - State G | electron microscopy | c | — | 1 (best 0.87) |
| 8IDY | human nuclear pre-60S ribosomal particle - State F | electron microscopy | c | — | 1 (best 0.89) |
| 8IE3 | human nuclear pre-60S ribosomal particle - State E | electron microscopy | c | — | 1 (best 0.86) |
| 8IFD | Dibekacin-added human 80S ribosome | electron microscopy | 2N | 84D, MG | 1 (best 0.89) |
| 8INE | human nuclear pre-60S ribosomal particle - State G' | electron microscopy | c | — | 1 (best 0.88) |
| 8INF | human nuclear pre-60S ribosomal particle - State F' | electron microscopy | c | — | — |
| 8INK | human nuclear pre-60S ribosomal particle - State D | electron microscopy | T | — | 1 (best 0.87) |
| 8IPX | human nuclear pre-60S ribosomal particle - State C' | electron microscopy | T | — | — |
24 records more on the page itself.
Ligands
Experiment against prediction
- 8A3D chain N against the predicted model P46778: TM-score 0.97, RMSD 0.93 Å
- 8OHD chain LT against the predicted model P46778: TM-score 0.97, RMSD 0.93 Å
- 8OJ8 chain LT against the predicted model P46778: TM-score 0.97, RMSD 0.94 Å
- 8XSX chain LT against the predicted model P46778: TM-score 0.97, RMSD 0.94 Å
- 8K2C chain LT against the predicted model P46778: TM-score 0.97, RMSD 0.94 Å
- 7XNX chain LT against the predicted model P46778: TM-score 0.97, RMSD 0.97 Å
- 8QYX chain N1 against the predicted model P46778: TM-score 0.97, RMSD 0.96 Å
- 8YOO chain LT against the predicted model P46778: TM-score 0.97, RMSD 0.95 Å
- 8XSY chain LT against the predicted model P46778: TM-score 0.97, RMSD 0.95 Å
- 9GMO chain N against the predicted model P46778: TM-score 0.97, RMSD 0.96 Å
Elsewhere
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