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Ligand · SPM

SPM · Spermine

SPM, Spermine (C10 H26 N4, 202.3 g/mol), in the MolNFT structures on GenesisL1: bound in 109 records (94 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands found with it.

Component
SPM
Formula
C10 H26 N4
Class
ligand
Structures
109
PDB entries
94

Binding sites

SPM in 109 structures; the first of them:

  • 5VJB · Guanidine-II riboswitch P2 hairpin dimer with 5-bromoU substitution from Pseudomonas… · SPM A102 · binds G5, G6, A7, C8, G9, A10, C11, C12
  • 5XJZ · Structure of DNA1-Ag complex · SPM B101 · binds DG1, DC2, DG5, DC6
  • 6E1X · Crystal structure of product-bound complex of spermidine/spermine N-acetyltransferase SpeG · SPM A201 · binds ASN22, MET28, TRP31, GLU33, GLU34, TYR36, GLU37, GLU41
  • 6GAW · Unique features of mammalian mitochondrial translation initiation revealed by cryo-EM.… · SPM BA3205 · binds G295, C296, A297, U687, A688, A689, C763, A764 and 2 more
  • 6GAZ · Unique features of mammalian mitochondrial translation initiation revealed by cryo-EM.… · SPM AA3001 · binds U299, G300, U301, U397, G398, A399, C400, A462 and 1 more
  • 6HIW · Cryo-EM structure of the Trypanosoma brucei mitochondrial ribosome - This entry contains… · SPM CA740 · binds GLN297, THR127, U66, U67, U95, U96, U97, U125 and 4 more
  • 6HIY · Cryo-EM structure of the Trypanosoma brucei mitochondrial ribosome - This entry contains… · SPM CA735 · binds GLN297, LYS424, THR127, U66, U67, U95, U96, U97 and 5 more
  • 6RSJ · Cytochrome c co-crystallized with 20 eq. sulfonato-calix[8]arene and soaked with 25 eq.… · SPM A205
  • 6RSK · Cytochrome c co-crystallized with 20 eq. sulfonato-calix[8]arene and 15 eq. spermine… · SPM A211 · binds ALA-1
  • 6RW5 · Structure of human mitochondrial 28S ribosome in complex with mitochondrial IF2 and IF3 · SPM A1702 · binds U944, G945, U946, U1044, G1045, A1046, A1047, C1048 and 2 more
  • 6XT7 · Tel25 Hybrid Four-quartet G-quadruplex with K+ · SPM B1106 · binds DT1003, DG1004, DT1021, DG1022
  • 6YEC · E.coli's Putrescine receptor PotF complexed with Spermine · SPM B501 · binds TRP37, SER38, ASP39, TYR40, ASN65, SER85, SER87, PHE88 and 8 more
  • 6YWE · The structure of the mitoribosome from Neurospora crassa in the P/E tRNA bound state · SPM A3636 · binds U1249, U1250, C1251, A1270, A1271, C1382, G1383, G1384 and 4 more
  • 6YWV · The structure of the Atp25 bound assembly intermediate of the mitoribosome from… · SPM A3644 · binds U1249, U1250, C1251, A1270, A1271, C1382, G1383, G1384 and 5 more
  • 6YWY · The structure of the mitoribosome from Neurospora crassa with bound tRNA at the P-site · SPM A3645 · binds U1249, A1270, A1271, C1382, G1383, G1384, U1392, ARG22 and 1 more
  • 7D5E · Left-handed G-quadruplex containing two bulges · SPM A104 · binds DG17, DG20, DT22, DG23, DG26
  • 7EDT · RNA duplex containing CC mispairs · SPM A401 · binds C4
  • 7FJQ · Cryo EM structure of lysosomal ATPase · SPM A1201 · binds TRP251, ASP254, HIS255, TYR259, ASP463, THR466, VAL467, TYR940 and 4 more
  • 7K00 · Structure of the Bacterial Ribosome at 2 Angstrom Resolution · SPM a6223 · binds A693, U694, G695, G696, G697, C698, U762, G763 and 7 more
  • 7L0Z · Spinach variant bound to DFHBI-1T · SPM G102 · binds G16, U17, G20, G21, U22, U42

Residues it binds most

G 217, C 175, A 172, U 160, GLU 83, TYR 106, ASP 75, ARG 90, LEU 47, GLN 49 (residue and the binding sites it lines).

Found with

  • MG · Magnesium ion
  • K · Potassium ion
  • ZN · Zinc ion
  • SPD · Spermidine
  • NA · Sodium ion
  • ATP · Adenosine-5'-triphosphate
  • SO4 · Sulfate ion
  • NAD · Nicotinamide-adenine-dinucleotide
  • NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose
  • CL · Chloride ion
  • ALF · Tetrafluoroaluminate ion
  • EVB · sulfonato-calix[8]arene

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