UniProt P18621
60S ribosomal protein L17 (P18621)
60S ribosomal protein L17 (UniProt P18621): 104 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 82 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P18621
- Protein
- 60S ribosomal protein L17
- Experimental structures
- 104
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 82 · 68 records with a druggable one
Structures
105 records of P18621 in the MolNFT archive: 104 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4UG0 | Structure of the human 80S ribosome | electron microscopy | LP | — | — |
| 4V6X | Structure of the human 80S ribosome | electron microscopy | CP | — | — |
| 5A8L | Human eRF1 and the hCMV nascent peptide in the translation termination complex | electron microscopy | D | — | — |
| 5A8L | Human ERF1 and the hcmv nascent peptide in the translation termination complex | electron microscopy | D | — | — |
| 5LKS | Structure-function insights reveal the human ribosome as a cancer target for antibiotics | electron microscopy | LP | MG | — |
| 6IP5 | Cryo-EM structure of the CMV-stalled human 80S ribosome (Structure ii) | electron microscopy | 2J | — | 3 (best 0.89) |
| 6IP6 | Cryo-EM structure of the CMV-stalled human 80S ribosome with HCV IRES (Structure iii) | electron microscopy | 2J | — | 3 (best 0.89) |
| 6IP8 | Cryo-EM structure of the HCV IRES dependently initiated CMV-stalled 80S ribosome (Structure iv) | electron microscopy | 2J | — | — |
| 6LQM | Cryo-EM structure of a pre-60S ribosomal subunit - state C | electron microscopy | Y | — | — |
| 6LSR | Cryo-EM structure of a pre-60S ribosomal subunit - state B | electron microscopy | Y | MG | 2 (best 0.88) |
| 6LSS | Cryo-EM structure of a pre-60S ribosomal subunit - state preA | electron microscopy | Y | MG | — |
| 6LU8 | Cryo-EM structure of a human pre-60S ribosomal subunit - state A | electron microscopy | Y | MG | 1 (best 0.85) |
| 6OLE | Human ribosome nascent chain complex (CDH1-RNC) stalled by a drug-like molecule with AP and PE tRNAs | electron microscopy | Q | — | — |
| 6OLF | Human ribosome nascent chain complex (CDH1-RNC) stalled by a drug-like molecule with AA and PE tRNAs | electron microscopy | Q | MVM | — |
| 6OLG | Human ribosome nascent chain complex stalled by a drug-like small molecule (CDH1_RNC with PP tRNA) | electron microscopy | AP | MG, MVM | — |
| 6OLI | Structure of human ribosome nascent chain complex selectively stalled by a drug-like small molecule… | electron microscopy | Q | — | — |
| 6OLZ | Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like molecule with PP tRNA | electron microscopy | AP | MG, MVM | 1 (best 0.88) |
| 6OM0 | Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like molecule with AP and PE… | electron microscopy | Q | MVM | — |
| 6OM7 | Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like small molecule with AA and… | electron microscopy | Q | MVM | 1 (best 0.87) |
| 6QZP | High-resolution cryo-EM structure of the human 80S ribosome | electron microscopy | LP | MG | — |
| 6W6L | Cryo-EM structure of the human ribosome-TMCO1 translocon | electron microscopy | Q | — | 1 (best 0.86) |
| 6XA1 | Structure of a drug-like compound stalled human translation termination complex | electron microscopy | LP | MG, MVM | 1 (best 0.86) |
| 6Y0G | Structure of human ribosome in classical-PRE state | electron microscopy | LP | — | 1 (best 0.86) |
| 6Y2L | Structure of human ribosome in POST state | electron microscopy | LP | MG | 1 (best 0.86) |
| 6Y57 | Structure of human ribosome in hybrid-PRE state | electron microscopy | LP | — | 1 (best 0.86) |
| 6Y6X | Tetracenomycin X bound to the human ribosome | electron microscopy | LP | MG | 1 (best 0.87) |
| 6Z6L | Cryo-EM structure of human CCDC124 bound to 80S ribosomes | electron microscopy | LP | MG | 1 (best 0.86) |
| 6Z6M | Cryo-EM structure of human 80S ribosomes bound to EBP1, eEF2 and SERBP1 | electron microscopy | LP | MG | 1 (best 0.86) |
| 6Z6N | Cryo-EM structure of human EBP1-80S ribosomes (focus on EBP1) | electron microscopy | LP | MG | 1 (best 0.86) |
| 6ZM7 | SARS-CoV-2 Nsp1 bound to the human CCDC124-80S-EBP1 ribosome complex | electron microscopy | LP | MG | 1 (best 0.85) |
| 6ZME | SARS-CoV-2 Nsp1 bound to the human CCDC124-80S-eERF1 ribosome complex | electron microscopy | LP | MG | 1 (best 0.87) |
| 6ZMI | SARS-CoV-2 Nsp1 bound to the human LYAR-80S ribosome complex | electron microscopy | LP | MG | 1 (best 0.86) |
| 6ZMO | SARS-CoV-2 Nsp1 bound to the human LYAR-80S-eEF1a ribosome complex | electron microscopy | LP | MG | — |
| 7BHP | Cryo-EM structure of the human Ebp1 - 80S ribosome | electron microscopy | LP | MG | 2 (best 0.86) |
| 7F5S | human delta-METTL18 60S ribosome | electron microscopy | LP | MG | 1 (best 0.87) |
| 7OW7 | EIF6-bound large subunit of the human ribosome | electron microscopy | J | MG, K | 1 (best 0.85) |
| 7QVP | Human collided disome (di-ribosome) stalled on XBP1 mRNA | electron microscopy | LP, MP | — | — |
| 7XNX | High resolution cry-EM structure of the human 80S ribosome from SNORD127+/+ Kasumi-1 cells | electron microscopy | LP | MG | — |
| 7XNY | High resolution cry-EM structure of the human 80S ribosome from SNORD127+/- Kasumi-1 cells | electron microscopy | LP | MG | — |
| 8A3D | Human mature large subunit of the ribosome with eIF6 and homoharringtonine bound | electron microscopy | J | MG, K | 1 (best 0.86) |
| 8FKP | Human nucleolar pre-60S ribosomal subunit (State A1) | electron microscopy | LA | — | 1 (best 0.83) |
| 8FKQ | Human nucleolar pre-60S ribosomal subunit (State A2) | electron microscopy | LA | — | — |
| 8FKR | Human nucleolar pre-60S ribosomal subunit (State B1) | electron microscopy | LA | — | 1 (best 0.84) |
| 8FKS | Human nucleolar pre-60S ribosomal subunit (State B2) | electron microscopy | LA | — | — |
| 8FKT | Human nucleolar pre-60S ribosomal subunit (State C1) | electron microscopy | LA | — | 1 (best 0.85) |
| 8FKU | Human nucleolar pre-60S ribosomal subunit (State C2) | electron microscopy | LA | — | — |
| 8FKV | Human nucleolar pre-60S ribosomal subunit (State D1) | electron microscopy | LA | — | 1 (best 0.84) |
| 8FKW | Human nucleolar pre-60S ribosomal subunit (State D2) | electron microscopy | LA | — | — |
| 8FKX | Human nucleolar pre-60S ribosomal subunit (State E) | electron microscopy | LA | — | — |
| 8FKY | Human nucleolar pre-60S ribosomal subunit (State F) | electron microscopy | LA | — | — |
| 8FKZ | Human nucleolar pre-60S ribosomal subunit (State G) | electron microscopy | LA | — | 1 (best 0.86) |
| 8FL2 | Human nuclear pre-60S ribosomal subunit (State I1) | electron microscopy | LA | — | 1 (best 0.86) |
| 8FL3 | Human nuclear pre-60S ribosomal subunit (State I2) | electron microscopy | LA | — | 2 (best 0.88) |
| 8FL4 | Human nuclear pre-60S ribosomal subunit (State I3) | electron microscopy | LA | — | 2 (best 0.88) |
| 8FL6 | Human nuclear pre-60S ribosomal subunit (State J1) | electron microscopy | LA | — | 1 (best 0.88) |
| 8FL7 | Human nuclear pre-60S ribosomal subunit (State J2) | electron microscopy | LA | MG | 1 (best 0.88) |
| 8FL9 | Human nuclear pre-60S ribosomal subunit (State J3) | electron microscopy | LA | MG | 2 (best 0.88) |
| 8FLA | Human nuclear pre-60S ribosomal subunit (State K1) | electron microscopy | LA | — | 2 (best 0.88) |
| 8FLB | Human nuclear pre-60S ribosomal subunit (State K2) | electron microscopy | LA | — | — |
| 8FLC | Human nuclear pre-60S ribosomal subunit (State K3) | electron microscopy | LA | — | 2 (best 0.88) |
45 records more on the page itself.
Ligands
Experiment against prediction
- 7OW7 chain J against the predicted model P18621: TM-score 0.99, RMSD 0.40 Å
- 8A3D chain J against the predicted model P18621: TM-score 0.99, RMSD 0.43 Å
- 8GLP chain LP against the predicted model P18621: TM-score 0.99, RMSD 0.47 Å
- 8YOO chain LP against the predicted model P18621: TM-score 0.99, RMSD 0.48 Å
- 8QOI chain LP against the predicted model P18621: TM-score 0.99, RMSD 0.47 Å
- 8QFD chain P against the predicted model P18621: TM-score 0.99, RMSD 0.48 Å
- 8G5Y chain LP against the predicted model P18621: TM-score 0.99, RMSD 0.49 Å
- 8G61 chain LP against the predicted model P18621: TM-score 0.99, RMSD 0.49 Å
- 8FL6 chain LA against the predicted model P18621: TM-score 0.99, RMSD 0.49 Å
- 8G6J chain LP against the predicted model P18621: TM-score 0.99, RMSD 0.49 Å
Elsewhere
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