UniProt P42766

60S ribosomal protein L35 (P42766)

60S ribosomal protein L35 (UniProt P42766): 57 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 83 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.

UniProt: P42766
Protein: 60S ribosomal protein L35
Experimental structures: 57
Predicted models: 1
Ligands: 1
Pockets: 83 · 42 records with a druggable one

Structures

58 records of P42766 in the MolNFT archive: 57 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
4UG0	Structure of the human 80S ribosome	electron microscopy	Lh	—	—
4V6X	Structure of the human 80S ribosome	electron microscopy	Ch	—	—
5LKS	Structure-function insights reveal the human ribosome as a cancer target for antibiotics	electron microscopy	Lh	—	—
6IP8	Cryo-EM structure of the HCV IRES dependently initiated CMV-stalled 80S ribosome (Structure iv)	electron microscopy	2b	—	—
6LQM	Cryo-EM structure of a pre-60S ribosomal subunit - state C	electron microscopy	H	—	—
6LSS	Cryo-EM structure of a pre-60S ribosomal subunit - state preA	electron microscopy	H	—	—
6LU8	Cryo-EM structure of a human pre-60S ribosomal subunit - state A	electron microscopy	H	—	1 (best 0.86)
6OLE	Human ribosome nascent chain complex (CDH1-RNC) stalled by a drug-like molecule with AP and PE tRNAs	electron microscopy	i	—	—
6OLF	Human ribosome nascent chain complex (CDH1-RNC) stalled by a drug-like molecule with AA and PE tRNAs	electron microscopy	i	—	—
6OLI	Structure of human ribosome nascent chain complex selectively stalled by a drug-like small molecule…	electron microscopy	i	—	—
6OM7	Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like small molecule with AA and…	electron microscopy	i	—	2 (best 0.88)
6XA1	Structure of a drug-like compound stalled human translation termination complex	electron microscopy	Lh	MG	1 (best 0.86)
6Y6X	Tetracenomycin X bound to the human ribosome	electron microscopy	Lh	—	2 (best 0.87)
6Z6L	Cryo-EM structure of human CCDC124 bound to 80S ribosomes	electron microscopy	Lh	—	1 (best 0.86)
6ZMO	SARS-CoV-2 Nsp1 bound to the human LYAR-80S-eEF1a ribosome complex	electron microscopy	Lh	—	3 (best 0.89)
7OW7	EIF6-bound large subunit of the human ribosome	electron microscopy	b	MG	4 (best 0.90)
7QVP	Human collided disome (di-ribosome) stalled on XBP1 mRNA	electron microscopy	Lh, Mh	—	—
7XNX	High resolution cry-EM structure of the human 80S ribosome from SNORD127+/+ Kasumi-1 cells	electron microscopy	Lh	—	2 (best 0.88)
7XNY	High resolution cry-EM structure of the human 80S ribosome from SNORD127+/- Kasumi-1 cells	electron microscopy	Lh	MG	1 (best 0.86)
8FKQ	Human nucleolar pre-60S ribosomal subunit (State A2)	electron microscopy	LS	—	3 (best 0.89)
8FKS	Human nucleolar pre-60S ribosomal subunit (State B2)	electron microscopy	LS	—	1 (best 0.84)
8FKU	Human nucleolar pre-60S ribosomal subunit (State C2)	electron microscopy	LS	—	1 (best 0.84)
8FKV	Human nucleolar pre-60S ribosomal subunit (State D1)	electron microscopy	LS	—	1 (best 0.85)
8FKW	Human nucleolar pre-60S ribosomal subunit (State D2)	electron microscopy	LS	—	1 (best 0.85)
8FKX	Human nucleolar pre-60S ribosomal subunit (State E)	electron microscopy	LS	—	2 (best 0.90)
8FKZ	Human nucleolar pre-60S ribosomal subunit (State G)	electron microscopy	LS	—	2 (best 0.87)
8FL2	Human nuclear pre-60S ribosomal subunit (State I1)	electron microscopy	LS	—	1 (best 0.87)
8FL3	Human nuclear pre-60S ribosomal subunit (State I2)	electron microscopy	LS	MG	2 (best 0.88)
8FL4	Human nuclear pre-60S ribosomal subunit (State I3)	electron microscopy	LS	—	2 (best 0.87)
8FL7	Human nuclear pre-60S ribosomal subunit (State J2)	electron microscopy	LS	MG	2 (best 0.88)
8FLB	Human nuclear pre-60S ribosomal subunit (State K2)	electron microscopy	LS	—	—
8FLD	Human nuclear pre-60S ribosomal subunit (State L1)	electron microscopy	LS	—	—
8FLE	Human nuclear pre-60S ribosomal subunit (State L2)	electron microscopy	LS	—	—
8G5Y	mRNA decoding in human is kinetically and structurally distinct from bacteria (IC state)	electron microscopy	Lh	MG	2 (best 0.89)
8G5Z	mRNA decoding in human is kinetically and structurally distinct from bacteria (GA state)	electron microscopy	Lh	MG	—
8G60	mRNA decoding in human is kinetically and structurally distinct from bacteria (CR state)	electron microscopy	Lh	—	1 (best 0.90)
8G61	mRNA decoding in human is kinetically and structurally distinct from bacteria (AC state)	electron microscopy	Lh	—	—
8GLP	mRNA decoding in human is kinetically and structurally distinct from bacteria (Consensus LSU…	electron microscopy	Lh	MG	2 (best 0.90)
8IE3	human nuclear pre-60S ribosomal particle - State E	electron microscopy	H	—	3 (best 0.89)
8INF	human nuclear pre-60S ribosomal particle - State F'	electron microscopy	H	—	3 (best 0.88)
8IR1	human nuclear pre-60S ribosomal particle - State A	electron microscopy	H	—	3 (best 0.86)
8IR3	human nuclear pre-60S ribosomal particle - State B'	electron microscopy	H	—	2 (best 0.89)
8JDJ	Structure of the Human cytoplasmic Ribosome with human tRNA Asp(Q34) and mRNA(GAU)	electron microscopy	m	MG	3 (best 0.89)
8JDK	Structure of the Human cytoplasmic Ribosome with human tRNA Asp(ManQ34) and mRNA(GAU)	electron microscopy	m	MG	1 (best 0.86)
8K2C	Cryo-EM structure of the human 80S ribosome with Tigecycline	electron microscopy	Lh	—	3 (best 0.89)
8OHD	60S ribosomal subunit bound to the E3-UFM1 complex - state 3 (native)	electron microscopy	Lh	MG	1 (best 0.86)
8OJ5	60S ribosomal subunit bound to the E3-UFM1 complex - state 3 (in-vitro reconstitution)	electron microscopy	Lh	MG	3 (best 0.86)
8OJ8	60S ribosomal subunit bound to the E3-UFM1 complex - state 1 (native)	electron microscopy	Lh	MG	3 (best 0.87)
8QYX	Human 60S ribosomal subunit	electron microscopy	b1	MG	2 (best 0.86)
8UKB	In situ HHT and CHX treated human hibernating state without E-tRNA 80S ribosome	electron microscopy	Lh	MG	2 (best 0.89)
8XSX	Cryo-EM structure of the human 80S ribosome with Tigecycline, E-tRNA, SERBP1 and eEF2	electron microscopy	Lh	—	4 (best 0.89)
8Y0W	dormant ribosome with eIF5A, eEF2 and SERBP1	electron microscopy	Lh	—	2 (best 0.88)
8YOP	Cryo-EM structure of the human 80S ribosome with 4 um Tigecycline	electron microscopy	Lh	—	1 (best 0.86)
9C3H	Structure of the CNOT3-bound human 80S ribosome with tRNA-ARG in the P-site.	electron microscopy	LO	—	1 (best 0.86)
9FPZ	Human NatA-MAP2 80S ribosome complex	electron microscopy	Lh	—	2 (best 0.76)
9FQ0	Human NatA-NAC-MAP1 80S ribosome complex	electron microscopy	Lh	—	3 (best 0.76)
9G8M	human 80S ribosome bound by a SKI2-exosome complex	electron microscopy	Lh	MG	1 (best 0.88)
P42766	AlphaFold monomer V2.0 prediction for 60S ribosomal protein L35 (P42766)	predicted	A	—	—

Ligands

MG · Magnesium ion · in 16 records

Experiment against prediction

8OHD chain Lh against the predicted model P42766: TM-score 0.96, RMSD 0.86 Å
8OJ5 chain Lh against the predicted model P42766: TM-score 0.96, RMSD 0.86 Å
8JDK chain m against the predicted model P42766: TM-score 0.96, RMSD 0.85 Å
6LSS chain H against the predicted model P42766: TM-score 0.96, RMSD 0.86 Å
9C3H chain LO against the predicted model P42766: TM-score 0.96, RMSD 0.86 Å
8JDJ chain m against the predicted model P42766: TM-score 0.96, RMSD 0.86 Å
8OJ8 chain Lh against the predicted model P42766: TM-score 0.96, RMSD 0.87 Å
8QYX chain b1 against the predicted model P42766: TM-score 0.96, RMSD 0.88 Å
6LU8 chain H against the predicted model P42766: TM-score 0.96, RMSD 0.88 Å
8GLP chain Lh against the predicted model P42766: TM-score 0.96, RMSD 0.89 Å

Elsewhere

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