UniProt P83881
60S ribosomal protein L36a (P83881)
60S ribosomal protein L36a (UniProt P83881): 53 experimental structures and 1 predicted model on GenesisL1, 9 ligands bound, 82 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P83881
- Protein
- 60S ribosomal protein L36a
- Experimental structures
- 53
- Predicted models
- 1
- Ligands
- 9
- Pockets
- 82 · 43 records with a druggable one
Structures
54 records of P83881 in the MolNFT archive: 53 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4UG0 | Structure of the human 80S ribosome | electron microscopy | Lo | — | — |
| 4V6X | Structure of the human 80S ribosome | electron microscopy | Co | — | — |
| 5LKS | Structure-function insights reveal the human ribosome as a cancer target for antibiotics | electron microscopy | Lo | 3HE, MG, ZN | — |
| 6IP5 | Cryo-EM structure of the CMV-stalled human 80S ribosome (Structure ii) | electron microscopy | 2i | — | 3 (best 0.89) |
| 6IP8 | Cryo-EM structure of the HCV IRES dependently initiated CMV-stalled 80S ribosome (Structure iv) | electron microscopy | 2i | — | — |
| 6LQM | Cryo-EM structure of a pre-60S ribosomal subunit - state C | electron microscopy | W | — | — |
| 6LSR | Cryo-EM structure of a pre-60S ribosomal subunit - state B | electron microscopy | W | MG | 1 (best 0.86) |
| 6LSS | Cryo-EM structure of a pre-60S ribosomal subunit - state preA | electron microscopy | W | — | — |
| 6LU8 | Cryo-EM structure of a human pre-60S ribosomal subunit - state A | electron microscopy | W | MG | 2 (best 0.88) |
| 6OLE | Human ribosome nascent chain complex (CDH1-RNC) stalled by a drug-like molecule with AP and PE tRNAs | electron microscopy | p | ZN | — |
| 6OLF | Human ribosome nascent chain complex (CDH1-RNC) stalled by a drug-like molecule with AA and PE tRNAs | electron microscopy | p | ZN | 2 (best 0.89) |
| 6OLG | Human ribosome nascent chain complex stalled by a drug-like small molecule (CDH1_RNC with PP tRNA) | electron microscopy | Ao | ZN | 1 (best 0.89) |
| 6OLI | Structure of human ribosome nascent chain complex selectively stalled by a drug-like small molecule… | electron microscopy | p | ZN | — |
| 6OM0 | Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like molecule with AP and PE… | electron microscopy | p | ZN | 1 (best 0.87) |
| 6OM7 | Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like small molecule with AA and… | electron microscopy | p | ZN | 3 (best 0.87) |
| 6QZP | High-resolution cryo-EM structure of the human 80S ribosome | electron microscopy | Lo | MG, ZN | 2 (best 0.90) |
| 6XA1 | Structure of a drug-like compound stalled human translation termination complex | electron microscopy | Lo | ZN | 1 (best 0.87) |
| 6Y2L | Structure of human ribosome in POST state | electron microscopy | Lo | 3HE, ZN | 2 (best 0.87) |
| 6Y57 | Structure of human ribosome in hybrid-PRE state | electron microscopy | Lo | ZN | 1 (best 0.86) |
| 6Y6X | Tetracenomycin X bound to the human ribosome | electron microscopy | Lo | MG, ZN | 3 (best 0.89) |
| 6Z6M | Cryo-EM structure of human 80S ribosomes bound to EBP1, eEF2 and SERBP1 | electron microscopy | Lo | ZN | 2 (best 0.89) |
| 6ZM7 | SARS-CoV-2 Nsp1 bound to the human CCDC124-80S-EBP1 ribosome complex | electron microscopy | Lo | MG, ZN | 1 (best 0.87) |
| 6ZMO | SARS-CoV-2 Nsp1 bound to the human LYAR-80S-eEF1a ribosome complex | electron microscopy | Lo | MG, ZN | 1 (best 0.87) |
| 7BHP | Cryo-EM structure of the human Ebp1 - 80S ribosome | electron microscopy | Lo | ZN | 2 (best 0.87) |
| 7F5S | human delta-METTL18 60S ribosome | electron microscopy | Lo | MG, ZN | 3 (best 0.89) |
| 7OW7 | EIF6-bound large subunit of the human ribosome | electron microscopy | i | MG, K, ZN | 2 (best 0.90) |
| 8A3D | Human mature large subunit of the ribosome with eIF6 and homoharringtonine bound | electron microscopy | i | MG, K, ZN | 2 (best 0.89) |
| 8IDT | human nuclear pre-60S ribosomal particle - State G | electron microscopy | W | — | 2 (best 0.89) |
| 8IDY | human nuclear pre-60S ribosomal particle - State F | electron microscopy | W | — | 1 (best 0.88) |
| 8IFD | Dibekacin-added human 80S ribosome | electron microscopy | 2i | 84D, MG | 2 (best 0.89) |
| 8INE | human nuclear pre-60S ribosomal particle - State G' | electron microscopy | W | — | 2 (best 0.88) |
| 8INF | human nuclear pre-60S ribosomal particle - State F' | electron microscopy | W | — | 3 (best 0.88) |
| 8JDJ | Structure of the Human cytoplasmic Ribosome with human tRNA Asp(Q34) and mRNA(GAU) | electron microscopy | t | ZN | 2 (best 0.89) |
| 8JDK | Structure of the Human cytoplasmic Ribosome with human tRNA Asp(ManQ34) and mRNA(GAU) | electron microscopy | t | MG, ZN | 3 (best 0.88) |
| 8JDL | Structure of the Human cytoplasmic Ribosome with human tRNA Tyr(GalQ34) and mRNA(UAU) (non-rotated… | electron microscopy | t | MG, ZN | 3 (best 0.89) |
| 8K2C | Cryo-EM structure of the human 80S ribosome with Tigecycline | electron microscopy | Lo | ZN, T1C | — |
| 8OHD | 60S ribosomal subunit bound to the E3-UFM1 complex - state 3 (native) | electron microscopy | Lo | ZN | 2 (best 0.88) |
| 8OJ5 | 60S ribosomal subunit bound to the E3-UFM1 complex - state 3 (in-vitro reconstitution) | electron microscopy | Lo | ZN | 2 (best 0.89) |
| 8OJ8 | 60S ribosomal subunit bound to the E3-UFM1 complex - state 1 (native) | electron microscopy | Lo | ZN | — |
| 8QFD | UFL1 E3 ligase bound 60S ribosome | electron microscopy | o | MG, ZN | 1 (best 0.89) |
| 8QOI | Structure of the human 80S ribosome at 1.9 A resolution - the molecular role of chemical… | electron microscopy | Lo | MG, ZN, K | 2 (best 0.89) |
| 8QYX | Human 60S ribosomal subunit | electron microscopy | i1 | ZN, SPM, ATP, MG | 1 (best 0.88) |
| 8UKB | In situ HHT and CHX treated human hibernating state without E-tRNA 80S ribosome | electron microscopy | Lo | MG, WV3, ZN | 2 (best 0.89) |
| 8XSX | Cryo-EM structure of the human 80S ribosome with Tigecycline, E-tRNA, SERBP1 and eEF2 | electron microscopy | Lo | ZN, T1C | 1 (best 0.89) |
| 8XSY | Cryo-EM structure of the human 80S ribosome with Tigecycline, e-tRNA and CCDC124 (40S head… | electron microscopy | Lo | MG, ZN, T1C | 2 (best 0.89) |
| 8XSZ | Cryo-EM structure of the human 80S ribosome with Tigecycline, E-tRNA and P-tRNA | electron microscopy | Lo | ZN | 2 (best 0.89) |
| 8Y0W | dormant ribosome with eIF5A, eEF2 and SERBP1 | electron microscopy | Lo | ZN | 2 (best 0.88) |
| 8Y0X | Dormant ribosome with SERBP1 | electron microscopy | Lo | MG, ZN | 1 (best 0.89) |
| 8YOO | Cryo-EM structure of the human 80S ribosome with 100 um Tigecycline | electron microscopy | Lo | ZN | 2 (best 0.87) |
| 8YOP | Cryo-EM structure of the human 80S ribosome with 4 um Tigecycline | electron microscopy | Lo | ZN | 2 (best 0.89) |
| 9C3H | Structure of the CNOT3-bound human 80S ribosome with tRNA-ARG in the P-site. | electron microscopy | Le | MG, ZN | 2 (best 0.89) |
| 9G8M | human 80S ribosome bound by a SKI2-exosome complex | electron microscopy | Lo | ZN | 2 (best 0.89) |
| 9GMO | eIF6-bound pre-60S large ribosomal subunit incorporating mutant uL16 | electron microscopy | i | K, MG, ZN | 3 (best 0.89) |
| P83881 | AlphaFold monomer V2.0 prediction for 60S ribosomal protein L36A (P83881) | predicted | A | — | — |
Ligands
- ZN · Zinc ion · in 40 records
- MG · Magnesium ion · in 21 records
- K · Potassium ion · in 4 records
- T1C · Tigecycline · in 3 records
- 3HE · 4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione · in 2 records
- 84D · Dibekacin · in 1 record
- ATP · Adenosine-5'-triphosphate · in 1 record
- SPM · Spermine · in 1 record
- WV3 · 4-{(2R)-2-[(1R,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione · in 1 record
Experiment against prediction
- 8QYX chain i1 against the predicted model P83881: TM-score 0.98, RMSD 0.56 Å
- 8OJ5 chain Lo against the predicted model P83881: TM-score 0.98, RMSD 0.59 Å
- 8OJ8 chain Lo against the predicted model P83881: TM-score 0.98, RMSD 0.59 Å
- 8A3D chain i against the predicted model P83881: TM-score 0.98, RMSD 0.60 Å
- 8OHD chain Lo against the predicted model P83881: TM-score 0.98, RMSD 0.60 Å
- 9C3H chain Le against the predicted model P83881: TM-score 0.98, RMSD 0.61 Å
- 8Y0X chain Lo against the predicted model P83881: TM-score 0.97, RMSD 0.61 Å
- 9GMO chain i against the predicted model P83881: TM-score 0.97, RMSD 0.64 Å
- 8QOI chain Lo against the predicted model P83881: TM-score 0.97, RMSD 0.64 Å
- 8XSX chain Lo against the predicted model P83881: TM-score 0.97, RMSD 0.66 Å
Elsewhere
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