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Ligand · T1C

T1C · Tigecycline

T1C, Tigecycline (C29 H41 N5 O8 +2, 587.7 g/mol), in the MolNFT structures on GenesisL1: bound in 10 records (9 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands found with it.

Component
T1C
Formula
C29 H41 N5 O8 +2
Class
ligand
Structures
10
PDB entries
9

Binding sites

T1C in 10 structures; the first of them:

  • 6YSI · Acinetobacter baumannii ribosome-tigecycline complex - 50S subunit · T1C 13160 · binds PHE75, G2307, U2308, A2309, G2310, C2321, A2322
  • 8K2A · Cryo-EM structure of the human 55S mitoribosome with Tigecycline · T1C L11706 · binds A292, C832, G1054, A1055, C1056, U1402, C1403, U1426
  • 8K2B · Cryo-EM structure of the human 39S mitoribosome with Tigecycline · T1C L11692 · binds C832, A1055, U1323, U1402, C1403, U1426
  • 8K2C · Cryo-EM structure of the human 80S ribosome with Tigecycline · T1C L55312 · binds A3711, U3734, G3735, U4068, U4069, U4070, U4071, C4072
  • 8K82 · Cryo-EM structure of the yeast 80S ribosome with tigecycline, Not5 and P-site tRNA · T1C C21990 · binds U578, C1190, U1191, U1272, G1273, C1274, A1275, A1427 and 2 more
  • 8XSX · Cryo-EM structure of the human 80S ribosome with Tigecycline, E-tRNA, SERBP1 and eEF2 · T1C L55312 · binds A3712, A3736, A3737, G970
  • 8XT1 · Cryo-EM structure of the human 39S mitoribosome with 5uM Tigecycline · T1C L11690 · binds C832, A1055, U1323, U1402, C1403, U1426
  • 6YSI · Acinetobacter baumannii ribosome-tigecycline complex - 50S subunit · T1C 13160 · binds PHE75, G2307, U2308, A2309, G2310, A2322
  • 6YTF · Acinetobacter baumannii ribosome-tigecycline complex - 30S subunit head · T1C 31624 · binds U1049, C1051, C1192, A1193, A1194, G1195
  • 7EPW · Crystal structure of monooxygenase TET(X4) with tigecycline · T1C A402 · binds ASN190, GLN192, ARG213, MET215, PHE224, ALA225, ASN226, HIS234 and 11 more

Residues it binds most

G 28, C 27, A 24, U 26, PHE 7, GLN 8, ARG 6, ASN 2, LYS 2, ALA 1 (residue and the binding sites it lines).

Found with

  • MG · Magnesium ion
  • ZN · Zinc ion
  • ADP · Adenosine-5'-diphosphate
  • FDA · Dihydroflavine-adenine dinucleotide
  • GDP · Guanosine-5'-diphosphate
  • PNS · 4'-phosphopantetheine
  • SPD · Spermidine

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