UniProt P61513
60S ribosomal protein L37a (P61513)
60S ribosomal protein L37a (UniProt P61513): 64 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 50 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P61513
- Protein
- 60S ribosomal protein L37a
- Experimental structures
- 64
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 50 · 45 records with a druggable one
Structures
65 records of P61513 in the MolNFT archive: 64 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4UG0 | Structure of the human 80S ribosome | electron microscopy | Lp | — | — |
| 4V6X | Structure of the human 80S ribosome | electron microscopy | Cp | — | — |
| 5LKS | Structure-function insights reveal the human ribosome as a cancer target for antibiotics | electron microscopy | Lp | ZN | — |
| 6IP8 | Cryo-EM structure of the HCV IRES dependently initiated CMV-stalled 80S ribosome (Structure iv) | electron microscopy | 2j | — | — |
| 6LQM | Cryo-EM structure of a pre-60S ribosomal subunit - state C | electron microscopy | X | — | — |
| 6LSS | Cryo-EM structure of a pre-60S ribosomal subunit - state preA | electron microscopy | X | — | — |
| 6LU8 | Cryo-EM structure of a human pre-60S ribosomal subunit - state A | electron microscopy | X | — | 1 (best 0.87) |
| 6OLE | Human ribosome nascent chain complex (CDH1-RNC) stalled by a drug-like molecule with AP and PE tRNAs | electron microscopy | q | ZN | — |
| 6OLF | Human ribosome nascent chain complex (CDH1-RNC) stalled by a drug-like molecule with AA and PE tRNAs | electron microscopy | q | ZN | — |
| 6OLI | Structure of human ribosome nascent chain complex selectively stalled by a drug-like small molecule… | electron microscopy | q | ZN | — |
| 6OM0 | Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like molecule with AP and PE… | electron microscopy | q | ZN | 1 (best 0.88) |
| 6OM7 | Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like small molecule with AA and… | electron microscopy | q | ZN | — |
| 6QZP | High-resolution cryo-EM structure of the human 80S ribosome | electron microscopy | Lp | ZN, MG | 1 (best 0.87) |
| 6XA1 | Structure of a drug-like compound stalled human translation termination complex | electron microscopy | Lp | ZN | 1 (best 0.87) |
| 6Y6X | Tetracenomycin X bound to the human ribosome | electron microscopy | Lp | ZN | 1 (best 0.88) |
| 6Z6L | Cryo-EM structure of human CCDC124 bound to 80S ribosomes | electron microscopy | Lp | ZN | 2 (best 0.87) |
| 6ZMO | SARS-CoV-2 Nsp1 bound to the human LYAR-80S-eEF1a ribosome complex | electron microscopy | Lp | ZN | 1 (best 0.87) |
| 7F5S | human delta-METTL18 60S ribosome | electron microscopy | Lp | ZN | 1 (best 0.86) |
| 7OW7 | EIF6-bound large subunit of the human ribosome | electron microscopy | j | ZN | 1 (best 0.86) |
| 7XNX | High resolution cry-EM structure of the human 80S ribosome from SNORD127+/+ Kasumi-1 cells | electron microscopy | Lp | ZN | — |
| 7XNY | High resolution cry-EM structure of the human 80S ribosome from SNORD127+/- Kasumi-1 cells | electron microscopy | Lp | ZN | 1 (best 0.87) |
| 8A3D | Human mature large subunit of the ribosome with eIF6 and homoharringtonine bound | electron microscopy | j | ZN | 1 (best 0.87) |
| 8FKZ | Human nucleolar pre-60S ribosomal subunit (State G) | electron microscopy | LX | ZN | 1 (best 0.87) |
| 8FL2 | Human nuclear pre-60S ribosomal subunit (State I1) | electron microscopy | LX | ZN | 2 (best 0.87) |
| 8FL3 | Human nuclear pre-60S ribosomal subunit (State I2) | electron microscopy | LX | ZN | 1 (best 0.87) |
| 8FL4 | Human nuclear pre-60S ribosomal subunit (State I3) | electron microscopy | LX | ZN | 1 (best 0.87) |
| 8FL6 | Human nuclear pre-60S ribosomal subunit (State J1) | electron microscopy | LX | ZN | 2 (best 0.87) |
| 8FL7 | Human nuclear pre-60S ribosomal subunit (State J2) | electron microscopy | LX | ZN | 1 (best 0.87) |
| 8FL9 | Human nuclear pre-60S ribosomal subunit (State J3) | electron microscopy | LX | ZN | 1 (best 0.87) |
| 8FLB | Human nuclear pre-60S ribosomal subunit (State K2) | electron microscopy | LX | ZN | — |
| 8FLC | Human nuclear pre-60S ribosomal subunit (State K3) | electron microscopy | LX | ZN | 1 (best 0.87) |
| 8FLD | Human nuclear pre-60S ribosomal subunit (State L1) | electron microscopy | LX | ZN | — |
| 8FLE | Human nuclear pre-60S ribosomal subunit (State L2) | electron microscopy | LX | ZN | — |
| 8FLF | Human nuclear pre-60S ribosomal subunit (State L3) | electron microscopy | LX | ZN | 1 (best 0.87) |
| 8G5Y | mRNA decoding in human is kinetically and structurally distinct from bacteria (IC state) | electron microscopy | Lp | ZN, MG | 1 (best 0.87) |
| 8G5Z | mRNA decoding in human is kinetically and structurally distinct from bacteria (GA state) | electron microscopy | Lp | ZN | 1 (best 0.87) |
| 8G60 | mRNA decoding in human is kinetically and structurally distinct from bacteria (CR state) | electron microscopy | Lp | ZN | 1 (best 0.87) |
| 8G61 | mRNA decoding in human is kinetically and structurally distinct from bacteria (AC state) | electron microscopy | Lp | ZN | 1 (best 0.86) |
| 8GLP | mRNA decoding in human is kinetically and structurally distinct from bacteria (Consensus LSU… | electron microscopy | Lp | MG, ZN | 1 (best 0.87) |
| 8IDT | human nuclear pre-60S ribosomal particle - State G | electron microscopy | X | — | 1 (best 0.86) |
| 8IE3 | human nuclear pre-60S ribosomal particle - State E | electron microscopy | X | — | 1 (best 0.86) |
| 8IFD | Dibekacin-added human 80S ribosome | electron microscopy | 2j | ZN | 1 (best 0.87) |
| 8INE | human nuclear pre-60S ribosomal particle - State G' | electron microscopy | X | — | — |
| 8INF | human nuclear pre-60S ribosomal particle - State F' | electron microscopy | X | — | — |
| 8INK | human nuclear pre-60S ribosomal particle - State D | electron microscopy | X | — | 2 (best 0.87) |
| 8IR1 | human nuclear pre-60S ribosomal particle - State A | electron microscopy | X | — | — |
| 8IR3 | human nuclear pre-60S ribosomal particle - State B' | electron microscopy | X | — | 1 (best 0.85) |
| 8JDJ | Structure of the Human cytoplasmic Ribosome with human tRNA Asp(Q34) and mRNA(GAU) | electron microscopy | u | MG, ZN | 1 (best 0.87) |
| 8JDK | Structure of the Human cytoplasmic Ribosome with human tRNA Asp(ManQ34) and mRNA(GAU) | electron microscopy | u | MG, ZN | 1 (best 0.87) |
| 8JDL | Structure of the Human cytoplasmic Ribosome with human tRNA Tyr(GalQ34) and mRNA(UAU) (non-rotated… | electron microscopy | u | MG, ZN | 1 (best 0.87) |
| 8K2C | Cryo-EM structure of the human 80S ribosome with Tigecycline | electron microscopy | Lp | ZN | 1 (best 0.87) |
| 8OHD | 60S ribosomal subunit bound to the E3-UFM1 complex - state 3 (native) | electron microscopy | Lp | ZN | 1 (best 0.87) |
| 8OJ5 | 60S ribosomal subunit bound to the E3-UFM1 complex - state 3 (in-vitro reconstitution) | electron microscopy | Lp | ZN | 1 (best 0.87) |
| 8OJ8 | 60S ribosomal subunit bound to the E3-UFM1 complex - state 1 (native) | electron microscopy | Lp | ZN | 1 (best 0.87) |
| 8QOI | Structure of the human 80S ribosome at 1.9 A resolution - the molecular role of chemical… | electron microscopy | Lp | ZN | 1 (best 0.87) |
| 8QYX | Human 60S ribosomal subunit | electron microscopy | j1 | ZN | 1 (best 0.87) |
| 8UKB | In situ HHT and CHX treated human hibernating state without E-tRNA 80S ribosome | electron microscopy | Lp | ZN | 1 (best 0.87) |
| 8XSX | Cryo-EM structure of the human 80S ribosome with Tigecycline, E-tRNA, SERBP1 and eEF2 | electron microscopy | Lp | ZN | 2 (best 0.87) |
| 8Y0W | dormant ribosome with eIF5A, eEF2 and SERBP1 | electron microscopy | Lp | ZN | — |
| 8Y0X | Dormant ribosome with SERBP1 | electron microscopy | Lp | ZN | 1 (best 0.86) |
5 records more on the page itself.
Ligands
Experiment against prediction
- 7OW7 chain j against the predicted model P61513: TM-score 0.97, RMSD 0.58 Å
- 9C3H chain Lp against the predicted model P61513: TM-score 0.97, RMSD 0.61 Å
- 4V6X chain Cp against the predicted model P61513: TM-score 0.97, RMSD 0.61 Å
- 6Y6X chain Lp against the predicted model P61513: TM-score 0.97, RMSD 0.64 Å
- 8G5Z chain Lp against the predicted model P61513: TM-score 0.97, RMSD 0.64 Å
- 8G61 chain Lp against the predicted model P61513: TM-score 0.97, RMSD 0.64 Å
- 8QOI chain Lp against the predicted model P61513: TM-score 0.97, RMSD 0.63 Å
- 8K2C chain Lp against the predicted model P61513: TM-score 0.97, RMSD 0.65 Å
- 8GLP chain Lp against the predicted model P61513: TM-score 0.97, RMSD 0.65 Å
- 8G60 chain Lp against the predicted model P61513: TM-score 0.97, RMSD 0.66 Å
Elsewhere
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