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UniProt P62269

40S ribosomal protein S18 (P62269)

40S ribosomal protein S18 (UniProt P62269): 44 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 13 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.

UniProt
P62269
Protein
40S ribosomal protein S18
Experimental structures
44
Predicted models
1
Ligands
3
Pockets
13 · 10 records with a druggable one

Structures

45 records of P62269 in the MolNFT archive: 44 experimental, 1 predicted.

EntryTitleMethodChainsLigandsPockets
4UG0Structure of the human 80S ribosomeelectron microscopySS——
4V6XStructure of the human 80S ribosomeelectron microscopyAS——
5A2QStructure of the HCV ires bound to the human ribosomeelectron microscopyS——
5FLXMammalian 40S HCV-ires complexelectron microscopyS——
5LKSStructure-function insights reveal the human ribosome as a cancer target for antibioticselectron microscopySS——
5OA3Human 40S-EIF2D-re-initiation complexelectron microscopyS——
6G18Cryo-EM structure of a late human pre-40S ribosomal subunit - state Celectron microscopyS——
6G4SCryo-EM structure of a late human pre-40S ribosomal subunit - state Belectron microscopyS——
6G4WCryo-EM structure of a late human pre-40S ribosomal subunit - state aelectron microscopyS——
6G51Cryo-EM structure of a late human pre-40S ribosomal subunit - state Delectron microscopyS——
6G53Cryo-EM structure of a late human pre-40S ribosomal subunit - state Eelectron microscopyS——
6G5HCryo-EM structure of a late human pre-40S ribosomal subunit - matureelectron microscopyS——
6G5ICryo-EM structure of a late human pre-40S ribosomal subunit - state Relectron microscopyS——
6IP8Cryo-EM structure of the HCV IRES dependently initiated CMV-stalled 80S ribosome (Structure iv)electron microscopy2z——
6OLEHuman ribosome nascent chain complex (CDH1-RNC) stalled by a drug-like molecule with AP and PE tRNAselectron microscopySS——
6OLIStructure of human ribosome nascent chain complex selectively stalled by a drug-like small molecule…electron microscopySS——
6YBSStructure of a human 48S translational initiation complex - headelectron microscopyfMG—
6ZLWSARS-cov-2 NSP1 bound to the human 40S ribosomal subunitelectron microscopyT——
6ZMTSARS-cov-2 NSP1 bound to a pre-40S-like ribosome complexelectron microscopyT——
6ZN5SARS-cov-2 NSP1 bound to a pre-40S-like ribosome complex - state 2electron microscopyT——
6ZOJSARS-CoV-2-Nsp1-40S complex, composite mapelectron microscopySMG—
6ZOJSARS-cov-2-NSP1-40S complex, composite MAPelectron microscopySMG—
6ZOLSARS-cov-2-NSP1-40S complex, focused on headelectron microscopySMG—
6ZUOHuman RIO1(KD)-stha late pre-40S particle, structural state a (pre 18S rRNA cleavage)electron microscopyS——
6ZV6Human RIO1(kd)-StHA late pre-40S particle, structural state B (post 18S rRNA cleavage)electron microscopyS—3 (best 0.86)
6ZV6Human RIO1(KD)-stha late pre-40S particle, structural state B (post 18S rRNA cleavage)electron microscopyS——
6ZVHEDF1-ribosome complexelectron microscopyS——
6ZXDCryo-EM structure of a late human pre-40S ribosomal subunit - state F1electron microscopyS——
6ZXECryo-EM structure of a late human pre-40S ribosomal subunit - state F2electron microscopyS——
6ZXFCryo-EM structure of a late human pre-40S ribosomal subunit - state Gelectron microscopyS——
6ZXGCryo-EM structure of a late human pre-40S ribosomal subunit - state H1electron microscopyS——
6ZXHCryo-EM structure of a late human pre-40S ribosomal subunit - state H2electron microscopyS——
7A09Structure of a human ABCE1-bound 43S pre-initiation complex - State IIIelectron microscopyk——
7K5ISARS-cov-2 NSP1 in complex with human 40S ribosomeelectron microscopyS——
7WTWCryo-EM structure of a human pre-40S ribosomal subunit - State RRP12-A3electron microscopyS—1 (best 0.81)
7WTXCryo-EM structure of a human pre-40S ribosomal subunit - State RRP12-B1electron microscopyS—1 (best 0.81)
7XNXHigh resolution cry-EM structure of the human 80S ribosome from SNORD127+/+ Kasumi-1 cellselectron microscopySS—1 (best 0.89)
7XNYHigh resolution cry-EM structure of the human 80S ribosome from SNORD127+/- Kasumi-1 cellselectron microscopySS—1 (best 0.87)
8G5YmRNA decoding in human is kinetically and structurally distinct from bacteria (IC state)electron microscopySSK, MG1 (best 0.88)
8G61mRNA decoding in human is kinetically and structurally distinct from bacteria (AC state)electron microscopySSMG1 (best 0.88)
8K2CCryo-EM structure of the human 80S ribosome with Tigecyclineelectron microscopySS——
8PPKBat-Hp-CoV Nsp1 and eIF1 bound to the human 40S small ribosomal subunitelectron microscopyS—2 (best 0.87)
8PPLMERS-CoV Nsp1 bound to the human 43S pre-initiation complexelectron microscopyASUNX, MG1 (best 0.86)
9G8Mhuman 80S ribosome bound by a SKI2-exosome complexelectron microscopySS—1 (best 0.88)
P62269AlphaFold monomer V2.0 prediction for 40S ribosomal protein S18 (P62269)predictedA——

Ligands

  • MG · Magnesium ion · in 7 records
  • K · Potassium ion · in 1 record
  • UNX · Unknown atom or ion · in 1 record

Experiment against prediction

Elsewhere

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