UniProt P62917

60S ribosomal protein L8 (P62917)

60S ribosomal protein L8 (UniProt P62917), EC 2.3.2.24: 84 experimental structures on GenesisL1, 2 ligands bound, 154 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.

UniProt: P62917
Protein: 60S ribosomal protein L8
EC: 2.3.2.24
Experimental structures: 84
Predicted models: 0
Ligands: 2
Pockets: 154 · 61 records with a druggable one

Structures

84 records of P62917 in the MolNFT archive: 84 experimental, 0 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
4CCM	60S ribosomal protein L8 histidine hydroxylase (NO66) in complex with Mn(II), N-oxalylglycine (NOG)…	x-ray diffraction	C, D	—	—
4CCM	60S ribosomal protein L8 histidine hydroxylase (NO66) in complex with MN(II), N-oxalylglycine (nog)…	x-ray diffraction	C, D	—	—
4CCN	60S ribosomal protein L8 histidine hydroxylase (NO66 L299C/C300S) in complex with Mn(II)…	x-ray diffraction	C, D	—	—
4CCN	60S ribosomal protein L8 histidine hydroxylase (NO66 L299C/C300S) in complex with MN(II)…	x-ray diffraction	C, D	—	—
4CCO	60S ribosomal protein L8 histidine hydroxylase (NO66 S373C) in complex with Mn(II), N-oxalylglycine…	x-ray diffraction	C, D	—	—
4CCO	60S ribosomal protein L8 histidine hydroxylase (NO66 S373C) in complex with MN(II), N-oxalylglycine…	x-ray diffraction	C, D	—	—
4UG0	Structure of the human 80S ribosome	electron microscopy	LA	—	—
4V6X	Structure of the human 80S ribosome	electron microscopy	CA	—	—
5LKS	Structure-function insights reveal the human ribosome as a cancer target for antibiotics	electron microscopy	LA	MG	—
6IP5	Cryo-EM structure of the CMV-stalled human 80S ribosome (Structure ii)	electron microscopy	1D	—	—
6IP8	Cryo-EM structure of the HCV IRES dependently initiated CMV-stalled 80S ribosome (Structure iv)	electron microscopy	1D	—	—
6LQM	Cryo-EM structure of a pre-60S ribosomal subunit - state C	electron microscopy	m	MG	—
6LSR	Cryo-EM structure of a pre-60S ribosomal subunit - state B	electron microscopy	m	MG	4 (best 0.87)
6LSS	Cryo-EM structure of a pre-60S ribosomal subunit - state preA	electron microscopy	m	MG	—
6LU8	Cryo-EM structure of a human pre-60S ribosomal subunit - state A	electron microscopy	m	MG	3 (best 0.88)
6OLE	Human ribosome nascent chain complex (CDH1-RNC) stalled by a drug-like molecule with AP and PE tRNAs	electron microscopy	A	MG	—
6OLF	Human ribosome nascent chain complex (CDH1-RNC) stalled by a drug-like molecule with AA and PE tRNAs	electron microscopy	A	MG	1 (best 0.86)
6OLG	Human ribosome nascent chain complex stalled by a drug-like small molecule (CDH1_RNC with PP tRNA)	electron microscopy	AA	MG	1 (best 0.86)
6OLI	Structure of human ribosome nascent chain complex selectively stalled by a drug-like small molecule…	electron microscopy	A	MG	—
6OM0	Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like molecule with AP and PE…	electron microscopy	A	MG	2 (best 0.88)
6OM7	Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like small molecule with AA and…	electron microscopy	A	MG	1 (best 0.86)
6QZP	High-resolution cryo-EM structure of the human 80S ribosome	electron microscopy	LA	MG	2 (best 0.88)
6W6L	Cryo-EM structure of the human ribosome-TMCO1 translocon	electron microscopy	A	MG	3 (best 0.87)
6XA1	Structure of a drug-like compound stalled human translation termination complex	electron microscopy	LA	MG	1 (best 0.87)
6Y2L	Structure of human ribosome in POST state	electron microscopy	LA	MG	2 (best 0.87)
6Y57	Structure of human ribosome in hybrid-PRE state	electron microscopy	LA	MG	—
6Y6X	Tetracenomycin X bound to the human ribosome	electron microscopy	LA	MG	3 (best 0.88)
6Z6L	Cryo-EM structure of human CCDC124 bound to 80S ribosomes	electron microscopy	LA	MG	3 (best 0.87)
6Z6M	Cryo-EM structure of human 80S ribosomes bound to EBP1, eEF2 and SERBP1	electron microscopy	LA	MG	3 (best 0.86)
6ZM7	SARS-CoV-2 Nsp1 bound to the human CCDC124-80S-EBP1 ribosome complex	electron microscopy	LA	MG	3 (best 0.87)
6ZMO	SARS-CoV-2 Nsp1 bound to the human LYAR-80S-eEF1a ribosome complex	electron microscopy	LA	MG	1 (best 0.87)
7BHP	Cryo-EM structure of the human Ebp1 - 80S ribosome	electron microscopy	LA	MG	2 (best 0.87)
7F5S	human delta-METTL18 60S ribosome	electron microscopy	LA	MG	2 (best 0.86)
7OW7	EIF6-bound large subunit of the human ribosome	electron microscopy	D	MG, K	3 (best 0.86)
7UN3	Complex of UBE2O with NAP1L1 and ubiquitylated uL2	electron microscopy	D, A	—	14 (best 0.79)
7UN3	Complex of UBE2O with NAP1L1 and ubiquitylated UL2	electron microscopy	D, A	—	—
7XNX	High resolution cry-EM structure of the human 80S ribosome from SNORD127+/+ Kasumi-1 cells	electron microscopy	LA	MG	2 (best 0.87)
7XNY	High resolution cry-EM structure of the human 80S ribosome from SNORD127+/- Kasumi-1 cells	electron microscopy	LA	MG	3 (best 0.87)
8A3D	Human mature large subunit of the ribosome with eIF6 and homoharringtonine bound	electron microscopy	D	MG, K	4 (best 0.87)
8FKZ	Human nucleolar pre-60S ribosomal subunit (State G)	electron microscopy	SF	—	2 (best 0.87)
8FL2	Human nuclear pre-60S ribosomal subunit (State I1)	electron microscopy	SF	MG	2 (best 0.87)
8FL3	Human nuclear pre-60S ribosomal subunit (State I2)	electron microscopy	SF	MG	1 (best 0.87)
8FL4	Human nuclear pre-60S ribosomal subunit (State I3)	electron microscopy	SF	MG	1 (best 0.87)
8FL6	Human nuclear pre-60S ribosomal subunit (State J1)	electron microscopy	SF	MG	3 (best 0.87)
8FL7	Human nuclear pre-60S ribosomal subunit (State J2)	electron microscopy	SF	MG	2 (best 0.87)
8FL9	Human nuclear pre-60S ribosomal subunit (State J3)	electron microscopy	SF	MG	2 (best 0.87)
8FLB	Human nuclear pre-60S ribosomal subunit (State K2)	electron microscopy	SF	MG	—
8FLC	Human nuclear pre-60S ribosomal subunit (State K3)	electron microscopy	SF	MG	3 (best 0.87)
8FLD	Human nuclear pre-60S ribosomal subunit (State L1)	electron microscopy	SF	MG	—
8FLE	Human nuclear pre-60S ribosomal subunit (State L2)	electron microscopy	SF	MG	—
8FLF	Human nuclear pre-60S ribosomal subunit (State L3)	electron microscopy	SF	MG	3 (best 0.87)
8IDT	human nuclear pre-60S ribosomal particle - State G	electron microscopy	m	—	2 (best 0.86)
8IDY	human nuclear pre-60S ribosomal particle - State F	electron microscopy	m	—	3 (best 0.86)
8IE3	human nuclear pre-60S ribosomal particle - State E	electron microscopy	m	—	2 (best 0.86)
8IFD	Dibekacin-added human 80S ribosome	electron microscopy	1D	MG	1 (best 0.87)
8INE	human nuclear pre-60S ribosomal particle - State G'	electron microscopy	m	—	2 (best 0.86)
8INF	human nuclear pre-60S ribosomal particle - State F'	electron microscopy	m	—	2 (best 0.88)
8INK	human nuclear pre-60S ribosomal particle - State D	electron microscopy	m	—	4 (best 0.87)
8IPX	human nuclear pre-60S ribosomal particle - State C'	electron microscopy	m	—	4 (best 0.87)
8IPY	human nuclear pre-60S ribosomal particle - State D'	electron microscopy	m	—	4 (best 0.87)

24 records more on the page itself.

Ligands

MG · Magnesium ion · in 60 records
K · Potassium ion · in 6 records

Experiment against prediction

7UN3 chain D against the predicted model P62987: TM-score 0.94, RMSD 0.77 Å
7UN3 chain D against the predicted model P62987: TM-score 0.94, RMSD 0.77 Å
7UN3 chain A against the predicted model Q9C0C9: TM-score 0.90, RMSD 3.22 Å
7UN3 chain A against the predicted model Q9C0C9: TM-score 0.90, RMSD 3.22 Å
7UN3 chain D against the predicted model Q9C0C9: TM-score 0.40, RMSD 3.78 Å
7UN3 chain D against the predicted model Q9C0C9: TM-score 0.40, RMSD 3.78 Å
7UN3 chain A against the predicted model P62987: TM-score 0.08, RMSD 4.67 Å
7UN3 chain A against the predicted model P62987: TM-score 0.08, RMSD 4.67 Å

Elsewhere

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