UniProt P62851

40S ribosomal protein S25 (P62851)

40S ribosomal protein S25 (UniProt P62851): 134 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 89 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.

UniProt: P62851
Protein: 40S ribosomal protein S25
Experimental structures: 134
Predicted models: 1
Ligands: 2
Pockets: 89 · 79 records with a druggable one

Structures

135 records of P62851 in the MolNFT archive: 134 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
4UG0	Structure of the human 80S ribosome	electron microscopy	SZ	—	—
4V6X	Structure of the human 80S ribosome	electron microscopy	AZ	—	—
5A2Q	Structure of the HCV IRES bound to the human ribosome	electron microscopy	Z	—	1 (best 0.90)
5A2Q	Structure of the HCV ires bound to the human ribosome	electron microscopy	Z	—	—
5FLX	Mammalian 40S HCV-IRES complex	electron microscopy	Z	—	1 (best 0.88)
5FLX	Mammalian 40S HCV-ires complex	electron microscopy	Z	—	—
5LKS	Structure-function insights reveal the human ribosome as a cancer target for antibiotics	electron microscopy	SZ	—	—
5OA3	Human 40S-EIF2D-re-initiation complex	electron microscopy	Z	—	—
5VYC	Crystal structure of the human 40S ribosomal subunit in complex with DENR-MCT-1.	x-ray diffraction	Z1, Z2, Z3, Z4, Z5, Z6	—	6 (best 0.89)
6FEC	Human cap-dependent 48S pre-initiation complex	electron microscopy	W	—	1 (best 0.88)
6G18	Cryo-EM structure of a late human pre-40S ribosomal subunit - State C	electron microscopy	Z	—	1 (best 0.83)
6G18	Cryo-EM structure of a late human pre-40S ribosomal subunit - state C	electron microscopy	Z	—	—
6G4S	Cryo-EM structure of a late human pre-40S ribosomal subunit - State B	electron microscopy	Z	—	—
6G4S	Cryo-EM structure of a late human pre-40S ribosomal subunit - state B	electron microscopy	Z	—	—
6G4W	Cryo-EM structure of a late human pre-40S ribosomal subunit - State A	electron microscopy	Z	—	1 (best 0.77)
6G4W	Cryo-EM structure of a late human pre-40S ribosomal subunit - state a	electron microscopy	Z	—	—
6G51	Cryo-EM structure of a late human pre-40S ribosomal subunit - State D	electron microscopy	Z	—	1 (best 0.80)
6G51	Cryo-EM structure of a late human pre-40S ribosomal subunit - state D	electron microscopy	Z	—	—
6G53	Cryo-EM structure of a late human pre-40S ribosomal subunit - State E	electron microscopy	Z	—	1 (best 0.82)
6G53	Cryo-EM structure of a late human pre-40S ribosomal subunit - state E	electron microscopy	Z	—	—
6G5H	Cryo-EM structure of a late human pre-40S ribosomal subunit - Mature	electron microscopy	Z	—	1 (best 0.90)
6G5H	Cryo-EM structure of a late human pre-40S ribosomal subunit - mature	electron microscopy	Z	—	—
6G5I	Cryo-EM structure of a late human pre-40S ribosomal subunit - State R	electron microscopy	Z	—	1 (best 0.88)
6G5I	Cryo-EM structure of a late human pre-40S ribosomal subunit - state R	electron microscopy	Z	—	—
6IP5	Cryo-EM structure of the CMV-stalled human 80S ribosome (Structure ii)	electron microscopy	3O	—	1 (best 0.90)
6IP6	Cryo-EM structure of the CMV-stalled human 80S ribosome with HCV IRES (Structure iii)	electron microscopy	3O	—	1 (best 0.87)
6IP8	Cryo-EM structure of the HCV IRES dependently initiated CMV-stalled 80S ribosome (Structure iv)	electron microscopy	3O	—	—
6OLE	Human ribosome nascent chain complex (CDH1-RNC) stalled by a drug-like molecule with AP and PE tRNAs	electron microscopy	SZ	—	—
6OLF	Human ribosome nascent chain complex (CDH1-RNC) stalled by a drug-like molecule with AA and PE tRNAs	electron microscopy	SZ	—	—
6OLG	Human ribosome nascent chain complex stalled by a drug-like small molecule (CDH1_RNC with PP tRNA)	electron microscopy	BZ	—	—
6OLI	Structure of human ribosome nascent chain complex selectively stalled by a drug-like small molecule…	electron microscopy	SZ	—	—
6OLZ	Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like molecule with PP tRNA	electron microscopy	BZ	—	1 (best 0.89)
6OM0	Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like molecule with AP and PE…	electron microscopy	SZ	—	1 (best 0.89)
6OM7	Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like small molecule with AA and…	electron microscopy	SZ	—	—
6QZP	High-resolution cryo-EM structure of the human 80S ribosome	electron microscopy	SZ	—	—
6XA1	Structure of a drug-like compound stalled human translation termination complex	electron microscopy	SZ	—	—
6Y0G	Structure of human ribosome in classical-PRE state	electron microscopy	SZ	—	1 (best 0.86)
6Y2L	Structure of human ribosome in POST state	electron microscopy	SZ	—	1 (best 0.86)
6Y57	Structure of human ribosome in hybrid-PRE state	electron microscopy	SZ	—	—
6YBS	Structure of a human 48S translational initiation complex - head	electron microscopy	e	—	1 (best 0.86)
6YBS	Structure of a human 48S translational initiation complex - head	electron microscopy	e	—	—
6Z6L	Cryo-EM structure of human CCDC124 bound to 80S ribosomes	electron microscopy	SZ	—	1 (best 0.86)
6Z6M	Cryo-EM structure of human 80S ribosomes bound to EBP1, eEF2 and SERBP1	electron microscopy	SZ	—	—
6Z6N	Cryo-EM structure of human EBP1-80S ribosomes (focus on EBP1)	electron microscopy	SZ	—	—
6ZLW	SARS-CoV-2 Nsp1 bound to the human 40S ribosomal subunit	electron microscopy	a	—	1 (best 0.83)
6ZLW	SARS-cov-2 NSP1 bound to the human 40S ribosomal subunit	electron microscopy	a	—	—
6ZM7	SARS-CoV-2 Nsp1 bound to the human CCDC124-80S-EBP1 ribosome complex	electron microscopy	SZ	—	—
6ZME	SARS-CoV-2 Nsp1 bound to the human CCDC124-80S-eERF1 ribosome complex	electron microscopy	SZ	—	1 (best 0.86)
6ZMI	SARS-CoV-2 Nsp1 bound to the human LYAR-80S ribosome complex	electron microscopy	SZ	—	1 (best 0.88)
6ZMO	SARS-CoV-2 Nsp1 bound to the human LYAR-80S-eEF1a ribosome complex	electron microscopy	SZ	—	1 (best 0.86)
6ZMT	SARS-CoV-2 Nsp1 bound to a pre-40S-like ribosome complex	electron microscopy	a	—	1 (best 0.86)
6ZMT	SARS-cov-2 NSP1 bound to a pre-40S-like ribosome complex	electron microscopy	a	—	—
6ZMW	Structure of a human 48S translational initiation complex	electron microscopy	e	—	1 (best 0.89)
6ZN5	SARS-CoV-2 Nsp1 bound to a pre-40S-like ribosome complex - state 2	electron microscopy	a	—	1 (best 0.81)
6ZN5	SARS-cov-2 NSP1 bound to a pre-40S-like ribosome complex - state 2	electron microscopy	a	—	—
6ZOJ	SARS-CoV-2-Nsp1-40S complex, composite map	electron microscopy	Z	—	—
6ZOJ	SARS-cov-2-NSP1-40S complex, composite MAP	electron microscopy	Z	—	—
6ZOL	SARS-CoV-2-Nsp1-40S complex, focused on head	electron microscopy	Z	MG	1 (best 0.88)
6ZOL	SARS-cov-2-NSP1-40S complex, focused on head	electron microscopy	Z	—	—
6ZON	SARS-CoV-2 Nsp1 bound to a human 43S preinitiation ribosome complex - state 1	electron microscopy	P	—	1 (best 0.85)

75 records more on the page itself.

Ligands

MG · Magnesium ion · in 2 records
UNX · Unknown atom or ion · in 1 record

Experiment against prediction

6ZP4 chain P against the predicted model P62851: TM-score 0.97, RMSD 0.48 Å
6YBS chain e against the predicted model P62851: TM-score 0.97, RMSD 0.47 Å
6YBS chain e against the predicted model P62851: TM-score 0.97, RMSD 0.47 Å
7QP7 chain e against the predicted model P62851: TM-score 0.97, RMSD 0.48 Å
8PJ6 chain e against the predicted model P62851: TM-score 0.97, RMSD 0.48 Å
6XA1 chain SZ against the predicted model P62851: TM-score 0.97, RMSD 0.50 Å
8PJ1 chain e against the predicted model P62851: TM-score 0.97, RMSD 0.50 Å
8PPL chain AZ against the predicted model P62851: TM-score 0.97, RMSD 0.53 Å
6ZOL chain Z against the predicted model P62851: TM-score 0.97, RMSD 0.55 Å
6ZOL chain Z against the predicted model P62851: TM-score 0.97, RMSD 0.55 Å

Elsewhere

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