MolNFT v2 · #137999 · protein
Nucleotide-driven Triple-state Remodeling of the AAA-ATPase Channel in the Activated Human 26S Proteasome
5VFU: “Nucleotide-driven Triple-state Remodeling of the AAA-ATPase Channel in the Activated Human 26S Proteasome”. Electron microscopy at 5.8, 1 ligand (ZN). MolNFT v2 #137999 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5VFU
- Type
- protein
- Length
- 12,887 residues
- Chains
- 46
- Method
- electron microscopy
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 5.8
- Source
- Homo sapiens
- UniProt
- Q99460, O43242, O00232, O00231, Q15008, P51665, Q9UNM6, P55036, O00487, P48556, P35998, P62191, P62195, P43686, P62333, P17980, P60900, P25787, P25789, O14818, P28066, P25786, P25788, P28072, Q99436, P49720, P49721, P28074, P20618, P28070, Q13200
- Ligands
- ZN
Structure
electron microscopy · resolution 5.8 · 32 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| U | — | protein | 806 | — | Q99460 |
| V | — | protein | 480 | — | O43242 |
| W | — | protein | 456 | — | O00232 |
| X | — | protein | 241 | — | O00231 |
| Y | — | protein | 378 | — | Q15008 |
| Z | — | protein | 286 | — | P51665 |
| a | — | protein | 373 | — | Q9UNM6 |
| b | — | protein | 191 | — | P55036 |
| c | — | protein | 278 | — | O00487 |
| d | — | protein | 257 | — | P48556 |
| e | — | protein | 40 | — | — |
| A | — | protein | 361 | — | P35998 |
| B | — | protein | 348 | — | P62191 |
| C | — | protein | 384 | — | P62195 |
| D | — | protein | 380 | — | P43686 |
| E | — | protein | 353 | — | P62333 |
| F | — | protein | 366 | — | P17980 |
| G, g | — | protein | 240 | — | P60900 |
| H, h | — | protein | 232 | — | P25787 |
| I, i | — | protein | 250 | — | P25789 |
| J, j | — | protein | 239 | — | O14818 |
| K, k | — | protein | 228 | — | P28066 |
| L, l | — | protein | 238 | — | P25786 |
| M, m | — | protein | 240 | — | P25788 |
| N, n | — | protein | 191 | — | P28072 |
| O, o | — | protein | 220 | — | Q99436 |
| P, p | — | protein | 204 | — | P49720 |
| Q, q | — | protein | 199 | — | P49721 |
| R, r | — | protein | 201 | — | P28074 |
| S, s | — | protein | 213 | — | P20618 |
| T, t | — | protein | 215 | — | P28070 |
| f | — | protein | 689 | — | Q13200 |
Ligands and binding sites
- ZN · Zinc ion · metal · chains c
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- P25786 · AlphaFold monomer V2.0 prediction for proteasome subunit alpha type-1 (P25786) · a predicted model of the same protein · chain L against A, TM-score 0.98
- P25788 · AlphaFold monomer V2.0 prediction for proteasome subunit alpha type-3 (P25788) · a predicted model of the same protein · chain M against A, TM-score 0.96
- P28066 · AlphaFold monomer V2.0 prediction for proteasome subunit alpha type-5 (P28066) · a predicted model of the same protein · chain K against A, TM-score 0.95
- P35998 · AlphaFold monomer V2.0 prediction for 26S proteasome regulatory subunit 7 (P35998) · a predicted model of the same protein · chain A against A, TM-score 0.90
- P17980 · AlphaFold monomer V2.0 prediction for 26S proteasome regulatory subunit 6A (P17980) · a predicted model of the same protein · chain F against A, TM-score 0.89
- Q9UNM6 · AlphaFold monomer V2.0 prediction for 26S proteasome non-ATPase regulatory subunit 13… · a predicted model of the same protein · chain a against A, TM-score 0.89
- O00487 · AlphaFold monomer V2.0 prediction for 26S proteasome non-ATPase regulatory subunit 14… · a predicted model of the same protein · chain c against A, TM-score 0.86
- O00232 · AlphaFold monomer V2.0 prediction for 26S proteasome non-ATPase regulatory subunit 12… · a predicted model of the same protein · chain W against A, TM-score 0.83
- O00231 · AlphaFold monomer V2.0 prediction for 26S proteasome non-ATPase regulatory subunit 11… · a predicted model of the same protein · chain X against A, TM-score 0.81
- P51665 · AlphaFold monomer V2.0 prediction for 26S proteasome non-ATPase regulatory subunit 7… · a predicted model of the same protein · chain Z against A, TM-score 0.80
- P48556 · AlphaFold monomer V2.0 prediction for 26S proteasome non-ATPase regulatory subunit 8… · a predicted model of the same protein · chain d against A, TM-score 0.79
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q99460
- Every structure of UniProt O43242
- Every structure of UniProt O00232
- Every structure of UniProt O00231
- Every structure of UniProt Q15008
- Every structure of UniProt P51665
- Every structure of UniProt Q9UNM6
- Every structure of UniProt P55036
- Every structure of UniProt O00487
- Every structure of UniProt P48556
- Every structure of UniProt P35998
- Every structure of UniProt P62191
- Every structure of UniProt P62195
- Every structure of UniProt P43686
- Every structure of UniProt P62333
- Every structure of UniProt P17980
- Every structure of UniProt P60900
- Every structure of UniProt P25787
- Every structure of UniProt P25789
- Every structure of UniProt O14818
- Every structure of UniProt P28066
- Every structure of UniProt P25786
- Every structure of UniProt P25788
- Every structure of UniProt P28072
- Every structure of UniProt Q99436
- Every structure of UniProt P49720
- Every structure of UniProt P49721
- Every structure of UniProt P28074
- Every structure of UniProt P20618
- Every structure of UniProt P28070
- Every structure of UniProt Q13200
- Elsewhere: RCSB PDB 5VFU · PDBe 5VFU · UniProt Q99460 · UniProt O43242 · UniProt O00232 · UniProt O00231 · UniProt Q15008 · UniProt P51665 · UniProt Q9UNM6 · UniProt P55036 · UniProt O00487 · UniProt P48556 · UniProt P35998 · UniProt P62191 · UniProt P62195 · UniProt P43686 · UniProt P62333 · UniProt P17980 · UniProt P60900 · UniProt P25787 · UniProt P25789 · UniProt O14818 · UniProt P28066 · UniProt P25786 · UniProt P25788 · UniProt P28072 · UniProt Q99436 · UniProt P49720 · UniProt P49721 · UniProt P28074 · UniProt P20618 · UniProt P28070 · UniProt Q13200
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