UniProt P25789
Proteasome subunit alpha type-4 (P25789)
Proteasome subunit alpha type-4 (UniProt P25789), EC 3.4.25.1: 120 experimental structures on GenesisL1, 1 ligand bound, 201 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P25789
- Protein
- Proteasome subunit alpha type-4
- EC
- 3.4.25.1
- Experimental structures
- 120
- Predicted models
- 0
- Ligands
- 1
- Pockets
- 201 · 62 records with a druggable one
Structures
120 records of P25789 in the MolNFT archive: 120 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4R3O | Human Constitutive 20S Proteasome | x-ray diffraction | C, Q | — | — |
| 4R3O | Human constitutive 20S proteasome | x-ray diffraction | C, Q | — | — |
| 4R67 | Human constitutive 20S proteasome in complex with carfilzomib | x-ray diffraction | C, Q, e, s | — | — |
| 4R67 | Human constitutive 20S proteasome in complex with carfilzomib | x-ray diffraction | C, Q, e, s | — | — |
| 5A0Q | Cryo-EM reveals the conformation of a substrate analogue in the human 20S proteasome core | electron microscopy | C, Q | — | — |
| 5GJQ | Structure of the human 26S proteasome bound to USP14-ubal | electron microscopy | D, j | — | — |
| 5GJR | An atomic structure of the human 26S proteasome | electron microscopy | D, j | — | — |
| 5L4G | The human 26S proteasome at 3.9 A | electron microscopy | P, C | — | — |
| 5LE5 | Native human 20S proteasome at 1.8 Angstrom | x-ray diffraction | B, P | CL | — |
| 5LE5 | Native human 20S proteasome at 1.8 ångström | x-ray diffraction | B, P | CL | — |
| 5LEX | Native human 20S proteasome in Mg-Acetate at 2.2 Angstrom | x-ray diffraction | B, P | — | — |
| 5LEX | Native human 20S proteasome in mg-acetate at 2.2 ångström | x-ray diffraction | B, P | — | — |
| 5LEY | Human 20S proteasome complex with Oprozomib at 1.9 Angstrom | x-ray diffraction | B, P | CL | 4 (best 0.80) |
| 5LEY | Human 20S proteasome complex with oprozomib at 1.9 ångström | x-ray diffraction | B, P | CL | — |
| 5LEZ | Human 20S proteasome complex with Oprozomib in Mg-Acetate at 2.2 Angstrom | x-ray diffraction | B, P | — | — |
| 5LEZ | Human 20S proteasome complex with oprozomib in mg-acetate at 2.2 ångström | x-ray diffraction | B, P | — | — |
| 5LF0 | Human 20S proteasome complex with Epoxomicin at 2.4 Angstrom | x-ray diffraction | B, P | CL | 5 (best 0.79) |
| 5LF0 | Human 20S proteasome complex with epoxomicin at 2.4 ångström | x-ray diffraction | B, P | CL | — |
| 5LF1 | Human 20S proteasome complex with Dihydroeponemycin at 2.0 Angstrom | x-ray diffraction | B, P | CL | 4 (best 0.79) |
| 5LF1 | Human 20S proteasome complex with dihydroeponemycin at 2.0 ångström | x-ray diffraction | B, P | CL | — |
| 5LF3 | Human 20S proteasome complex with Bortezomib at 2.1 Angstrom | x-ray diffraction | B, P | CL | 4 (best 0.79) |
| 5LF3 | Human 20S proteasome complex with bortezomib at 2.1 ångström | x-ray diffraction | B, P | CL | — |
| 5LF4 | Human 20S proteasome complex with Delanzomib at 2.0 Angstrom | x-ray diffraction | B, P | CL | — |
| 5LF4 | Human 20S proteasome complex with delanzomib at 2.0 ångström | x-ray diffraction | B, P | CL | — |
| 5LF6 | Human 20S proteasome complex with Z-LLY-ketoaldehyde at 2.1 Angstrom | x-ray diffraction | B, P | CL | 4 (best 0.80) |
| 5LF6 | Human 20S proteasome complex with Z-lly-ketoaldehyde at 2.1 ångström | x-ray diffraction | B, P | CL | — |
| 5LF7 | Human 20S proteasome complex with Ixazomib at 2.0 Angstrom | x-ray diffraction | B, P | CL | — |
| 5LF7 | Human 20S proteasome complex with ixazomib at 2.0 ångström | x-ray diffraction | B, P | CL | — |
| 5LN3 | The human 26S Proteasome at 6.8 Ang. | electron microscopy | C | — | 4 (best 0.81) |
| 5LN3 | The human 26S proteasome at 6.8 ang. | electron microscopy | C | — | — |
| 5M32 | Human 26S proteasome in complex with Oprozomib | electron microscopy | B, P | — | 2 (best 0.77) |
| 5M32 | Human 26S proteasome in complex with oprozomib | electron microscopy | B, P | — | — |
| 5T0C | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | AI, BI | — | — |
| 5T0G | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | I | — | 2 (best 0.81) |
| 5T0G | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | I | — | — |
| 5T0H | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | I | — | 2 (best 0.79) |
| 5T0H | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | I | — | — |
| 5T0I | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | I | — | 2 (best 0.85) |
| 5T0I | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | I | — | — |
| 5T0J | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | I | — | 3 (best 0.81) |
| 5T0J | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | I | — | — |
| 5VFO | Nucleotide-driven Triple-state Remodeling of the AAA-ATPase Channel in the Activated Human 26S… | electron microscopy | I, i | — | 4 (best 0.79) |
| 5VFO | Nucleotide-driven triple-state remodeling of the aaa-ATPase channel in the activated human 26S… | electron microscopy | I, i | — | — |
| 5VFP | Nucleotide-driven Triple-state Remodeling of the AAA-ATPase Channel in the Activated Human 26S… | electron microscopy | I, i | — | 1 (best 0.81) |
| 5VFQ | Nucleotide-driven Triple-state Remodeling of the AAA-ATPase Channel in the Activated Human 26S… | electron microscopy | I, i | — | 2 (best 0.81) |
| 5VFR | Nucleotide-driven Triple-state Remodeling of the AAA-ATPase Channel in the Activated Human 26S… | electron microscopy | I, i | — | 2 (best 0.80) |
| 5VFR | Nucleotide-driven triple-state remodeling of the aaa-ATPase channel in the activated human 26S… | electron microscopy | I, i | — | — |
| 5VFS | Nucleotide-Driven Triple-State Remodeling of the AAA-ATPase Channel in the Activated Human 26S… | electron microscopy | I, i | — | 2 (best 0.80) |
| 5VFT | Nucleotide-driven Triple-state Remodeling of the AAA-ATPase Channel in the Activated Human 26S… | electron microscopy | I, i | — | 2 (best 0.79) |
| 5VFT | Nucleotide-driven triple-state remodeling of the aaa-ATPase channel in the activated human 26S… | electron microscopy | I, i | — | — |
| 5VFU | Nucleotide-driven Triple-state Remodeling of the AAA-ATPase Channel in the Activated Human 26S… | electron microscopy | I, i | — | — |
| 6AVO | Cryo-EM structure of human immunoproteasome with a novel noncompetitive inhibitor that selectively… | electron microscopy | O, Z | — | 4 (best 0.80) |
| 6AVO | Cryo-EM structure of human immunoproteasome with a novel noncompetitive inhibitor that selectively… | electron microscopy | O, Z | — | — |
| 6E5B | Human Immunoproteasome 20S particle in complex with compound 1 | x-ray diffraction | B, P | — | — |
| 6E5B | Human immunoproteasome 20S particle in complex with compound 1 | x-ray diffraction | B, P | — | — |
| 6KWY | human PA200-20S complex | electron microscopy | B, P | — | 4 (best 0.81) |
| 6KWY | Human PA200-20S complex | electron microscopy | B, P | — | — |
| 6MSB | Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome | electron microscopy | I, i | — | 3 (best 0.79) |
| 6MSD | Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome | electron microscopy | I, i | — | 3 (best 0.83) |
| 6MSE | Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome | electron microscopy | I, i | — | 2 (best 0.82) |
60 records more on the page itself.
Ligands
- CL · Chloride ion · in 16 records
Elsewhere
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