MolNFT v1 · #105394 · protein
Human constitutive 20S proteasome
4R3O · Proteasome subunit alpha type-6: “Human constitutive 20S proteasome”. X-ray diffraction, 20 pockets (best druggability 0.80). MolNFT v1 #105394 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4R3O
- Type
- protein
- Length
- 6,286 residues
- Chains
- 28
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Proteasome subunit alpha type-6; Proteasome subunit alpha type-2; Proteasome subunit…
- EC
- 3.4.25.1
- UniProt
- P60900, P25787, P25789, O14818, P28066, P25786, P25788, P28072, Q99436, P49720, P49721, P28074, P20618, P28070
- Pockets
- 20 · best druggability 0.80
Structure
x-ray diffraction · 14 distinct chains · 34% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, O | Proteasome subunit alpha type-6 (EC 3.4.25.1) | protein | 244 | 36% helix, 25% strand | P60900 |
| B, P | Proteasome subunit alpha type-2 (EC 3.4.25.1) | protein | 233 | 32% helix, 25% strand | P25787 |
| C, Q | Proteasome subunit alpha type-4 (EC 3.4.25.1) | protein | 250 | 36% helix, 25% strand | P25789 |
| D, R | Proteasome subunit alpha type-7 (EC 3.4.25.1) | protein | 243 | 36% helix, 22% strand | O14818 |
| E, S | Proteasome subunit alpha type-5 (EC 3.4.25.1) | protein | 234 | 33% helix, 29% strand | P28066 |
| F, T | Proteasome subunit alpha type-1 (EC 3.4.25.1) | protein | 238 | 34% helix, 26% strand | P25786 |
| G, U | Proteasome subunit alpha type-3 (EC 3.4.25.1) | protein | 245 | 35% helix, 27% strand | P25788 |
| H, V | Proteasome subunit beta type-6 (EC 3.4.25.1) | protein | 202 | 35% helix, 30% strand | P28072 |
| I, W | Proteasome subunit beta type-7 (EC 3.4.25.1) | protein | 220 | 30% helix, 32% strand | Q99436 |
| J, X | Proteasome subunit beta type-3 (EC 3.4.25.1) | protein | 204 | 30% helix, 31% strand | P49720 |
| K, Y | Proteasome subunit beta type-2 (EC 3.4.25.1) | protein | 199 | 32% helix, 34% strand | P49721 |
| L, Z | Proteasome subunit beta type-5 (EC 3.4.25.1) | protein | 201 | 36% helix, 34% strand | P28074 |
| M, 1 | Proteasome subunit beta type-1 (EC 3.4.25.1) | protein | 213 | 30% helix, 32% strand | P20618 |
| N, 2 | Proteasome subunit beta type-4 (EC 3.4.25.1) | protein | 217 | 34% helix, 33% strand | P28070 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 750 | 0.80 | 0.83 | 83 | empty |
| 2 | 715 | 0.80 | 0.84 | 81 | empty |
| 3 | 857 | 0.79 | 0.81 | 104 | empty |
| 4 | 1136 | 0.77 | 0.79 | 113 | empty |
| 5 | 865 | 0.77 | 0.81 | 98 | empty |
Interfaces
84 interfaces between chains.
- I–J · 1615 Ų buried · 26 hydrogen bonds · protein-protein
- W–X · 1612 Ų buried · 26 hydrogen bonds · protein-protein
- A–B · 1473 Ų buried · 18 hydrogen bonds · protein-protein
- O–P · 1468 Ų buried · 18 hydrogen bonds · protein-protein
- Q–R · 1463 Ų buried · 19 hydrogen bonds · protein-protein
Compared structures
- 4R3O · Human Constitutive 20S Proteasome · the same entry in another collection · chain K against K, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P60900
- Every structure of UniProt P25787
- Every structure of UniProt P25789
- Every structure of UniProt O14818
- Every structure of UniProt P28066
- Every structure of UniProt P25786
- Every structure of UniProt P25788
- Every structure of UniProt P28072
- Every structure of UniProt Q99436
- Every structure of UniProt P49720
- Every structure of UniProt P49721
- Every structure of UniProt P28074
- Every structure of UniProt P20618
- Every structure of UniProt P28070
- Elsewhere: RCSB PDB 4R3O · PDBe 4R3O · UniProt P60900 · UniProt P25787 · UniProt P25789 · UniProt O14818 · UniProt P28066 · UniProt P25786 · UniProt P25788 · UniProt P28072 · UniProt Q99436 · UniProt P49720 · UniProt P49721 · UniProt P28074 · UniProt P20618 · UniProt P28070
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