UniProt Q99436

Proteasome subunit beta type-7 (Q99436)

Proteasome subunit beta type-7 (UniProt Q99436), EC 3.4.25.1: 73 experimental structures on GenesisL1, 19 ligands bound, 35 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.

UniProt: Q99436
Protein: Proteasome subunit beta type-7
EC: 3.4.25.1
Experimental structures: 73
Predicted models: 0
Ligands: 19
Pockets: 35 · 9 records with a druggable one

Structures

73 records of Q99436 in the MolNFT archive: 73 experimental, 0 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
4R3O	Human Constitutive 20S Proteasome	x-ray diffraction	I, W	—	—
4R3O	Human constitutive 20S proteasome	x-ray diffraction	I, W	—	—
4R67	Human constitutive 20S proteasome in complex with carfilzomib	x-ray diffraction	I, W, k, y	—	—
4R67	Human constitutive 20S proteasome in complex with carfilzomib	x-ray diffraction	I, W, k, y	—	—
5A0Q	Cryo-EM reveals the conformation of a substrate analogue in the human 20S proteasome core	electron microscopy	I, W	—	—
5GJQ	Structure of the human 26S proteasome bound to USP14-ubal	electron microscopy	b, p	—	—
5GJR	An atomic structure of the human 26S proteasome	electron microscopy	b, p	—	—
5L4G	The human 26S proteasome at 3.9 A	electron microscopy	8, 7	—	—
5LE5	Native human 20S proteasome at 1.8 Angstrom	x-ray diffraction	H, V	MG, CL	—
5LE5	Native human 20S proteasome at 1.8 ångström	x-ray diffraction	H, V	MG, CL	—
5LEX	Native human 20S proteasome in Mg-Acetate at 2.2 Angstrom	x-ray diffraction	H, V	MG	—
5LEX	Native human 20S proteasome in mg-acetate at 2.2 ångström	x-ray diffraction	H, V	MG	—
5LEY	Human 20S proteasome complex with oprozomib at 1.9 ångström	x-ray diffraction	H, V	MG, CL	—
5LEZ	Human 20S proteasome complex with Oprozomib in Mg-Acetate at 2.2 Angstrom	x-ray diffraction	H, V	MG	—
5LEZ	Human 20S proteasome complex with oprozomib in mg-acetate at 2.2 ångström	x-ray diffraction	H, V	6V9, MG	—
5LF0	Human 20S proteasome complex with epoxomicin at 2.4 ångström	x-ray diffraction	H, V	ACE, 6VO, CL, MG	—
5LF1	Human 20S proteasome complex with dihydroeponemycin at 2.0 ångström	x-ray diffraction	H, V	MG, CL, 6VC	—
5LF3	Human 20S proteasome complex with Bortezomib at 2.1 Angstrom	x-ray diffraction	H, V	CL, MG, BO2	6 (best 0.80)
5LF3	Human 20S proteasome complex with bortezomib at 2.1 ångström	x-ray diffraction	H, V	CL, MG, BO2	—
5LF4	Human 20S proteasome complex with Delanzomib at 2.0 Angstrom	x-ray diffraction	H, V	MG, CL, 6V7	—
5LF4	Human 20S proteasome complex with delanzomib at 2.0 ångström	x-ray diffraction	H, V	MG, CL, 6V7	—
5LF6	Human 20S proteasome complex with Z-lly-ketoaldehyde at 2.1 ångström	x-ray diffraction	H, V	MG, CL	—
5LF7	Human 20S proteasome complex with Ixazomib at 2.0 Angstrom	x-ray diffraction	H, V	MG, CL, 6V8	—
5LF7	Human 20S proteasome complex with ixazomib at 2.0 ångström	x-ray diffraction	H, V	MG, CL, 6V8	—
5LN3	The human 26S proteasome at 6.8 ang.	electron microscopy	2	—	—
5M32	Human 26S proteasome in complex with oprozomib	electron microscopy	H, V	—	—
5T0G	Structural basis for dynamic regulation of the human 26S proteasome	electron microscopy	O	—	1 (best 0.84)
5T0G	Structural basis for dynamic regulation of the human 26S proteasome	electron microscopy	O	—	—
5T0H	Structural basis for dynamic regulation of the human 26S proteasome	electron microscopy	O	—	—
5T0I	Structural basis for dynamic regulation of the human 26S proteasome	electron microscopy	O	—	—
5T0J	Structural basis for dynamic regulation of the human 26S proteasome	electron microscopy	O	—	—
5VFO	Nucleotide-driven triple-state remodeling of the aaa-ATPase channel in the activated human 26S…	electron microscopy	O, o	—	—
5VFR	Nucleotide-driven triple-state remodeling of the aaa-ATPase channel in the activated human 26S…	electron microscopy	O, o	—	—
5VFT	Nucleotide-driven triple-state remodeling of the aaa-ATPase channel in the activated human 26S…	electron microscopy	O, o	—	—
5VFU	Nucleotide-driven Triple-state Remodeling of the AAA-ATPase Channel in the Activated Human 26S…	electron microscopy	O, o	—	—
6HTB	Yeast 20S proteasome with human beta2c (S171G)	x-ray diffraction	H, V	MG	6 (best 0.78)
6HTB	Yeast 20S proteasome with human BETA2C (S171G)	x-ray diffraction	H, V	MG	—
6HTC	Yeast 20S proteasome with human BETA2C (S171G) in complex with onx 0914	x-ray diffraction	H, V	GQK, MG	—
6HTD	Yeast 20S proteasome with human BETA2C (S171G) in complex with 4	x-ray diffraction	H, V	GQH, MG	—
6HTP	Yeast 20S proteasome with human beta2c (S171G) in complex with 7	x-ray diffraction	H, V	GQQ, MG	—
6HTP	Yeast 20S proteasome with human BETA2C (S171G) in complex with 7	x-ray diffraction	H, V	GQQ, MG	—
6HTR	Yeast 20S proteasome with human beta2c (S171G) in complex with 13	x-ray diffraction	H, V	GQT, MG	—
6HTR	Yeast 20S proteasome with human BETA2C (S171G) in complex with 13	x-ray diffraction	H, V	GQT, MG	—
6HUB	Yeast 20S proteasome with human beta2c (S171G) in complex with 16	x-ray diffraction	H, V	GRW, MG	—
6HUB	Yeast 20S proteasome with human BETA2C (S171G) in complex with 16	x-ray diffraction	H, V	GRW, MG	—
6HUC	Yeast 20S proteasome with human beta2c (S171G) in complex with 18	x-ray diffraction	H, V	GRT, MG	—
6HUC	Yeast 20S proteasome with human BETA2C (S171G) in complex with 18	x-ray diffraction	H, V	GRT, MG	—
6HUQ	Yeast 20S proteasome with human BETA2C (S171G) in complex with 20	x-ray diffraction	H, V	GT5, MG	—
6HUU	Yeast 20S proteasome with human beta2c (S171G) in complex with 29	x-ray diffraction	H, V	GTW, MG	—
6HUU	Yeast 20S proteasome with human BETA2C (S171G) in complex with 29	x-ray diffraction	H, V	GTW, MG	—
6HUV	Yeast 20S proteasome with human beta2c (S171G) in complex with 39	x-ray diffraction	H, V	GT8, MG	—
6HUV	Yeast 20S proteasome with human BETA2C (S171G) in complex with 39	x-ray diffraction	H, V	GT8, MG	—
6KWY	Human PA200-20S complex	electron microscopy	H, V	—	—
6MSD	Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome	electron microscopy	O, o	—	2 (best 0.83)
6R70	Endogeneous native human 20S proteasome	electron microscopy	H, V	—	—
6REY	Human 20S-PA200 proteasome complex	electron microscopy	I, W	—	—
6RGQ	Human 20S proteasome	electron microscopy	I, W	—	—
6WJN	Sd-like state of human 26S proteasome with non-cleavable M1-linked hexaubiquitin and E3 ubiquitin…	electron microscopy	O, o	—	—
6XMJ	Human 20S proteasome bound to an engineered 11S (PA26) activator	electron microscopy	I	—	—
7LXV	Structure of human 20S proteasome with bound mpi-5	electron microscopy	H, V	—	—

13 records more on the page itself.

Ligands

MG · Magnesium ion · in 33 records
CL · Chloride ion · in 12 records
6V7 · [(1~{R})-3-methyl-1-[[(2~{S},3~{S})-3-oxidanyl-2-[(6-phenylpyridin-2-yl) carbonylamino]butanoyl]amino]butyl]boronic acid · in 2 records
6V8 · [(1~{R})-1-[2-[[2,5-bis(chloranyl) phenyl]carbonylamino]ethanoylamino]-3-methyl-butyl]boronic acid · in 2 records
BO2 · N-[(1R)-1-(dihydroxyboryl)-3-methylbutyl]-N-(pyrazin-2-ylcarbonyl)-L-phenylalaninamide · in 2 records
GQQ · ~{N}-[(2~{S})-1-[[(2~{S})-1-[[(2~{S})-1-[4-(aminomethyl)phenyl]-4-methylsulfonyl-butan-2-yl]amino]-4-methyl-1-oxidanylidene-pentan-2-yl]amino]-4-methyl-1-oxidanylidene-pentan-2-yl]pyrazine-2-carboxamide · in 2 records
GQT · (2~{S})-~{N}-[(2~{S})-1-[[(2~{S})-1-[4-(aminomethyl) phenyl]-4-methylsulfonyl-butan-2-yl]amino]-3-oxidanyl-1-oxidanylidene-propan-2-yl]-2-[[(2~{S})-2-azido-3-phenyl-propanoyl]amino]-4-methyl-pentanamide · in 2 records
GRT · (2~{S})-~{N}-[2-[[(2~{S})-1-[4-(aminomethyl)phenyl]-4-methylsulfonyl-butan-2-yl]amino]-2-oxidanylidene-ethyl]-2-[[(2~{S})-2-azido-3-phenyl-propanoyl]amino]-4-methyl-pentanamide · in 2 records
GRW · (2~{S})-~{N}-[(2~{S},3~{R})-1-[[(2~{S})-1-[4-(aminomethyl)phenyl]-4-methylsulfonyl-butan-2-yl]amino]-3-oxidanyl-1-oxidanylidene-butan-2-yl]-2-[[(2~{R})-2-azido-3-phenyl-propanoyl]amino]-4-methyl-pentanamide · in 2 records
GT8 · (2~{S})-~{N}-[(3~{S},4~{R})-1-cyclohexyl-5-methyl-4,5-bis(oxidanyl)hexan-3-yl]-3-(4-methoxyphenyl)-2-[[(2~{S})-2-(2-morpholin-4-ylethanoylamino) propanoyl]amino]propanamide · in 2 records
GTW · ~{N}-[(2~{S})-1-[[(2~{S})-1-[[(2~{S})-1-[4-(aminomethyl)phenyl]-4-methylsulfonyl-butan-2-yl]amino]-3-cyclohexyl-1-oxidanylidene-propan-2-yl]amino]-4-methyl-1-oxidanylidene-pentan-2-yl]-2-methyl-1,3-thiazole-5-carboxamide · in 2 records
6V9 · 2-methyl-1,3-thiazole-5-carboxylic acid · in 1 record
6VC · ~{N}-[(2~{S})-1-[[(2~{S},3~{R},4~{S})-2,6-dimethyl-1,2, 3-tris(oxidanyl)heptan-4-yl]amino]-3-oxidanyl-1-oxidanylidene-propan-2-yl]-6-methyl-heptanamide · in 1 record
6VO · (3~{R},4~{S})-4-azanyl-2,6-dimethyl-heptane-2,3-diol · in 1 record
ACE · Acetyl group · in 1 record
GQH · (2~{S})-~{N}-[(2~{S})-1-[[(2~{S})-1-[4-(aminomethyl) phenyl]-4-methylsulfonyl-butan-2-yl]amino]-1-oxidanylidene-propan-2-yl]-2-[[(2~{S})-2-azido-3-phenyl-propanoyl]amino]-4-methyl-pentanamide · in 1 record
GQK · (2~{S})-3-(4-methoxyphenyl)-~{N}-[(2~{S},3~{R})-4-methyl-3,4-bis(oxidanyl)-1-phenyl-pentan-2-yl]-2-[[(2~{S})-2-(2-morpholin-4-ylethanoylamino) propanoyl]amino]propanamide · in 1 record
GT5 · ~{N}-[(2~{S})-1-[[(2~{S})-1-[[(2~{S})-1-[4-(aminomethyl)phenyl]-4-methylsulfonyl-butan-2-yl]amino]-3-methoxy-1-oxidanylidene-propan-2-yl]amino]-4-methyl-1-oxidanylidene-pentan-2-yl]-2-methyl-1,3-thiazole-5-carboxamide · in 1 record
LDZ · N-[(benzyloxy)carbonyl]-L-leucyl-N-[(2S)-4-methyl-1-oxopentan-2-yl]-L-leucinamide · in 1 record

Elsewhere

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