UniProt P60900

Proteasome subunit alpha type-6 (P60900)

Proteasome subunit alpha type-6 (UniProt P60900), EC 3.4.25.1: 145 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 472 pockets. Binding sites, druggability and experiment against prediction (TM-score)…

UniProt: P60900
Protein: Proteasome subunit alpha type-6
EC: 3.4.25.1
Experimental structures: 145
Predicted models: 1
Ligands: 4
Pockets: 472 · 127 records with a druggable one

Structures

146 records of P60900 in the MolNFT archive: 145 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
4R3O	Human Constitutive 20S Proteasome	x-ray diffraction	A, O	—	6 (best 0.79)
4R3O	Human constitutive 20S proteasome	x-ray diffraction	A, O	—	6 (best 0.79)
4R67	Human constitutive 20S proteasome in complex with carfilzomib	x-ray diffraction	A, O, c, q	—	5 (best 0.78)
4R67	Human constitutive 20S proteasome in complex with carfilzomib	x-ray diffraction	A, O, c, q	—	5 (best 0.78)
5A0Q	Cryo-EM reveals the conformation of a substrate analogue in the human 20S proteasome core	electron microscopy	A, O	—	1 (best 0.69)
5GJQ	Structure of the human 26S proteasome bound to USP14-ubal	electron microscopy	B, h	—	3 (best 0.80)
5GJR	An atomic structure of the human 26S proteasome	electron microscopy	B, h	—	1 (best 0.84)
5L4G	The human 26S proteasome at 3.9 A	electron microscopy	N, A	—	4 (best 0.75)
5LE5	Native human 20S proteasome at 1.8 Angstrom	x-ray diffraction	G, U	CL, K	6 (best 0.77)
5LE5	Native human 20S proteasome at 1.8 ångström	x-ray diffraction	G, U	CL, K	6 (best 0.77)
5LEX	Native human 20S proteasome in Mg-Acetate at 2.2 Angstrom	x-ray diffraction	G, U	K	6 (best 0.75)
5LEX	Native human 20S proteasome in mg-acetate at 2.2 ångström	x-ray diffraction	G, U	K	6 (best 0.75)
5LEY	Human 20S proteasome complex with Oprozomib at 1.9 Angstrom	x-ray diffraction	G, U	CL, K	6 (best 0.78)
5LEY	Human 20S proteasome complex with oprozomib at 1.9 ångström	x-ray diffraction	G, U	CL, K	6 (best 0.78)
5LEZ	Human 20S proteasome complex with Oprozomib in Mg-Acetate at 2.2 Angstrom	x-ray diffraction	G, U	K	6 (best 0.77)
5LEZ	Human 20S proteasome complex with oprozomib in mg-acetate at 2.2 ångström	x-ray diffraction	G, U	K	6 (best 0.77)
5LF0	Human 20S proteasome complex with Epoxomicin at 2.4 Angstrom	x-ray diffraction	G, U	CL, K	6 (best 0.76)
5LF0	Human 20S proteasome complex with epoxomicin at 2.4 ångström	x-ray diffraction	G, U	CL, K	6 (best 0.76)
5LF1	Human 20S proteasome complex with Dihydroeponemycin at 2.0 Angstrom	x-ray diffraction	G, U	CL, K	6 (best 0.77)
5LF1	Human 20S proteasome complex with dihydroeponemycin at 2.0 ångström	x-ray diffraction	G, U	CL, K	6 (best 0.77)
5LF3	Human 20S proteasome complex with Bortezomib at 2.1 Angstrom	x-ray diffraction	G, U	CL, K	6 (best 0.76)
5LF3	Human 20S proteasome complex with bortezomib at 2.1 ångström	x-ray diffraction	G, U	CL, K	6 (best 0.76)
5LF4	Human 20S proteasome complex with Delanzomib at 2.0 Angstrom	x-ray diffraction	G, U	CL, K	5 (best 0.76)
5LF4	Human 20S proteasome complex with delanzomib at 2.0 ångström	x-ray diffraction	G, U	CL, K	5 (best 0.76)
5LF6	Human 20S proteasome complex with Z-LLY-ketoaldehyde at 2.1 Angstrom	x-ray diffraction	G, U	CL, K, NEN	6 (best 0.78)
5LF6	Human 20S proteasome complex with Z-lly-ketoaldehyde at 2.1 ångström	x-ray diffraction	G, U	CL, K	6 (best 0.77)
5LF7	Human 20S proteasome complex with Ixazomib at 2.0 Angstrom	x-ray diffraction	G, U	CL, K	5 (best 0.76)
5LF7	Human 20S proteasome complex with ixazomib at 2.0 ångström	x-ray diffraction	G, U	CL, K	5 (best 0.76)
5LN3	The human 26S Proteasome at 6.8 Ang.	electron microscopy	A	—	1 (best 0.79)
5LN3	The human 26S proteasome at 6.8 ang.	electron microscopy	A	—	1 (best 0.79)
5M32	Human 26S proteasome in complex with Oprozomib	electron microscopy	G, U	—	4 (best 0.78)
5M32	Human 26S proteasome in complex with oprozomib	electron microscopy	G, U	—	4 (best 0.78)
5T0C	Structural basis for dynamic regulation of the human 26S proteasome	electron microscopy	AG, BG	—	2 (best 0.83)
5T0G	Structural basis for dynamic regulation of the human 26S proteasome	electron microscopy	G	—	1 (best 0.84)
5T0G	Structural basis for dynamic regulation of the human 26S proteasome	electron microscopy	G	—	1 (best 0.84)
5T0H	Structural basis for dynamic regulation of the human 26S proteasome	electron microscopy	G	—	1 (best 0.81)
5T0H	Structural basis for dynamic regulation of the human 26S proteasome	electron microscopy	G	—	1 (best 0.81)
5T0I	Structural basis for dynamic regulation of the human 26S proteasome	electron microscopy	G	—	2 (best 0.85)
5T0I	Structural basis for dynamic regulation of the human 26S proteasome	electron microscopy	G	—	2 (best 0.85)
5T0J	Structural basis for dynamic regulation of the human 26S proteasome	electron microscopy	G	—	1 (best 0.85)
5T0J	Structural basis for dynamic regulation of the human 26S proteasome	electron microscopy	G	—	1 (best 0.85)
5VFO	Nucleotide-driven Triple-state Remodeling of the AAA-ATPase Channel in the Activated Human 26S…	electron microscopy	G, g	—	5 (best 0.79)
5VFO	Nucleotide-driven triple-state remodeling of the aaa-ATPase channel in the activated human 26S…	electron microscopy	G, g	—	5 (best 0.79)
5VFP	Nucleotide-driven Triple-state Remodeling of the AAA-ATPase Channel in the Activated Human 26S…	electron microscopy	G, g	—	2 (best 0.84)
5VFQ	Nucleotide-driven Triple-state Remodeling of the AAA-ATPase Channel in the Activated Human 26S…	electron microscopy	G, g	—	1 (best 0.80)
5VFR	Nucleotide-driven Triple-state Remodeling of the AAA-ATPase Channel in the Activated Human 26S…	electron microscopy	G, g	—	2 (best 0.79)
5VFR	Nucleotide-driven triple-state remodeling of the aaa-ATPase channel in the activated human 26S…	electron microscopy	G, g	—	2 (best 0.79)
5VFS	Nucleotide-Driven Triple-State Remodeling of the AAA-ATPase Channel in the Activated Human 26S…	electron microscopy	G, g	—	3 (best 0.86)
5VFT	Nucleotide-driven Triple-state Remodeling of the AAA-ATPase Channel in the Activated Human 26S…	electron microscopy	G, g	—	2 (best 0.79)
5VFT	Nucleotide-driven triple-state remodeling of the aaa-ATPase channel in the activated human 26S…	electron microscopy	G, g	—	2 (best 0.79)
5VFU	Nucleotide-driven Triple-state Remodeling of the AAA-ATPase Channel in the Activated Human 26S…	electron microscopy	G, g	—	1 (best 0.79)
6AVO	Cryo-EM structure of human immunoproteasome with a novel noncompetitive inhibitor that selectively…	electron microscopy	K, R	—	4 (best 0.78)
6AVO	Cryo-EM structure of human immunoproteasome with a novel noncompetitive inhibitor that selectively…	electron microscopy	K, R	—	4 (best 0.78)
6E5B	Human Immunoproteasome 20S particle in complex with compound 1	x-ray diffraction	G, U	NA	3 (best 0.77)
6E5B	Human immunoproteasome 20S particle in complex with compound 1	x-ray diffraction	G, U	NA	3 (best 0.77)
6KWY	human PA200-20S complex	electron microscopy	G, U	—	5 (best 0.85)
6KWY	Human PA200-20S complex	electron microscopy	G, U	—	—
6MSB	Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome	electron microscopy	G, g	—	2 (best 0.79)
6MSD	Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome	electron microscopy	G, g	—	2 (best 0.83)
6MSE	Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome	electron microscopy	G, g	—	2 (best 0.83)

86 records more on the page itself.

Ligands

K · Potassium ion · in 23 records
CL · Chloride ion · in 17 records
NA · Sodium ion · in 6 records
NEN · 1-ethyl-pyrrolidine-2,5-dione · in 1 record

Experiment against prediction

5LE5 chain U against the predicted model P60900: TM-score 1.00, RMSD 0.34 Å
5LF7 chain U against the predicted model P60900: TM-score 0.99, RMSD 0.43 Å
5LF1 chain U against the predicted model P60900: TM-score 0.99, RMSD 0.43 Å
5LF6 chain U against the predicted model P60900: TM-score 0.99, RMSD 0.43 Å
5LEY chain U against the predicted model P60900: TM-score 0.99, RMSD 0.44 Å
5LEZ chain U against the predicted model P60900: TM-score 0.99, RMSD 0.44 Å
5LF3 chain U against the predicted model P60900: TM-score 0.99, RMSD 0.45 Å
5LEX chain U against the predicted model P60900: TM-score 0.99, RMSD 0.45 Å
5LF4 chain U against the predicted model P60900: TM-score 0.99, RMSD 0.46 Å
5LF0 chain U against the predicted model P60900: TM-score 0.99, RMSD 0.46 Å

Elsewhere

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