MolNFT v1 · #125635 · protein
Human 20S proteasome complex with oprozomib at 1.9 ångström
5LEY: “Human 20S proteasome complex with oprozomib at 1.9 ångström”. X-ray diffraction, 5 ligands (6V9, 6VA, MG). MolNFT v1 #125635 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5LEY
- Type
- protein
- Length
- 6,235 residues
- Chains
- 30
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P25787, P25789, O14818, P28066, P25786, P25788, P60900, Q99436, P49720, P49721, P28074, P20618, P28070, P28072
- Ligands
- 6V9, 6VA, MG, K, CL
Structure
x-ray diffraction · 22 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, O | — | protein | 230 | — | P25787 |
| B | — | protein | 248 | — | P25789 |
| C | — | protein | 237 | — | O14818 |
| D, R | — | protein | 233 | — | P28066 |
| E | — | protein | 234 | — | P25786 |
| F | — | protein | 239 | — | P25788 |
| G | — | protein | 244 | — | P60900 |
| H, V | — | protein | 220 | — | Q99436 |
| I, W | — | protein | 204 | — | P49720 |
| J, X | — | protein | 196 | — | P49721 |
| K | — | protein | 200 | — | P28074 |
| L, Z | — | protein | 213 | — | P20618 |
| M, a | — | protein | 216 | — | P28070 |
| N | — | protein | 202 | — | P28072 |
| P | — | protein | 247 | — | P25789 |
| Q | — | protein | 240 | — | O14818 |
| S | — | protein | 236 | — | P25786 |
| T | — | protein | 240 | — | P25788 |
| U | — | protein | 238 | — | P60900 |
| Y | — | protein | 199 | — | P28074 |
| b | — | protein | 203 | — | P28072 |
| c, d | — | protein | 2 | — | — |
Ligands and binding sites
- 6V9 · 2-methyl-1,3-thiazole-5-carboxylic acid · ligand · 2 copies · chains K, L, c, Y, Z, d
- 6VA · (3~{R},4~{S})-4-azanyl-2-methyl-5-phenyl-pentane-2,3-diol · ligand · 2 copies · chains K, c, Y, d
- MG · Magnesium ion · metal · 10 copies · chains H, N, Z, I, Y, K, W, L, V, b
- K · Potassium ion · metal · 6 copies · chains G, L, N, U, Z, b
- CL · Chloride ion · ion · 58 copies · chains A, C, G, B, D, E, F, N, H, I, K, J, M, O, Q, W, U, V, P, R, S, Y, X, a, b
- 1PE · Pentaethylene glycol · additive · 9 copies · chains G, H, N, Z, a, I, J, D, K, L, M, V, b, U, W, X, R, Y
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 5LEY · Human 20S proteasome complex with Oprozomib at 1.9 Angstrom · the same entry in another collection · chain K against K, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P25787
- Every structure of UniProt P25789
- Every structure of UniProt O14818
- Every structure of UniProt P28066
- Every structure of UniProt P25786
- Every structure of UniProt P25788
- Every structure of UniProt P60900
- Every structure of UniProt Q99436
- Every structure of UniProt P49720
- Every structure of UniProt P49721
- Every structure of UniProt P28074
- Every structure of UniProt P20618
- Every structure of UniProt P28070
- Every structure of UniProt P28072
- Elsewhere: RCSB PDB 5LEY · PDBe 5LEY · UniProt P25787 · UniProt P25789 · UniProt O14818 · UniProt P28066 · UniProt P25786 · UniProt P25788 · UniProt P60900 · UniProt Q99436 · UniProt P49720 · UniProt P49721 · UniProt P28074 · UniProt P20618 · UniProt P28070 · UniProt P28072
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