UniProt P49721
Proteasome subunit beta type-2 (P49721)
Proteasome subunit beta type-2 (UniProt P49721), EC 3.4.25.1: 96 experimental structures on GenesisL1, 5 ligands bound, 72 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P49721
- Protein
- Proteasome subunit beta type-2
- EC
- 3.4.25.1
- Experimental structures
- 96
- Predicted models
- 0
- Ligands
- 5
- Pockets
- 72 · 37 records with a druggable one
Structures
96 records of P49721 in the MolNFT archive: 96 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4R3O | Human Constitutive 20S Proteasome | x-ray diffraction | K, Y | — | — |
| 4R3O | Human constitutive 20S proteasome | x-ray diffraction | K, Y | — | — |
| 4R67 | Human constitutive 20S proteasome in complex with carfilzomib | x-ray diffraction | K, Y, m, 0 | — | — |
| 4R67 | Human constitutive 20S proteasome in complex with carfilzomib | x-ray diffraction | K, Y, m, 0 | — | — |
| 5A0Q | Cryo-EM reveals the conformation of a substrate analogue in the human 20S proteasome core | electron microscopy | K, Y | — | — |
| 5GJQ | Structure of the human 26S proteasome bound to USP14-ubal | electron microscopy | d, r | — | — |
| 5GJR | An atomic structure of the human 26S proteasome | electron microscopy | d, r | — | — |
| 5L4G | The human 26S proteasome at 3.9 A | electron microscopy | V, 2 | — | — |
| 5LE5 | Native human 20S proteasome at 1.8 Angstrom | x-ray diffraction | J, X | CL | — |
| 5LE5 | Native human 20S proteasome at 1.8 ångström | x-ray diffraction | J, X | CL | — |
| 5LEX | Native human 20S proteasome in Mg-Acetate at 2.2 Angstrom | x-ray diffraction | J, X | MG | — |
| 5LEX | Native human 20S proteasome in mg-acetate at 2.2 ångström | x-ray diffraction | J, X | MG | — |
| 5LEY | Human 20S proteasome complex with Oprozomib at 1.9 Angstrom | x-ray diffraction | J, X | MG, CL | 2 (best 0.79) |
| 5LEY | Human 20S proteasome complex with oprozomib at 1.9 ångström | x-ray diffraction | J, X | CL | — |
| 5LEZ | Human 20S proteasome complex with Oprozomib in Mg-Acetate at 2.2 Angstrom | x-ray diffraction | J, X | — | — |
| 5LEZ | Human 20S proteasome complex with oprozomib in mg-acetate at 2.2 ångström | x-ray diffraction | J, X | — | — |
| 5LF0 | Human 20S proteasome complex with Epoxomicin at 2.4 Angstrom | x-ray diffraction | J, X | MG, CL | 2 (best 0.78) |
| 5LF0 | Human 20S proteasome complex with epoxomicin at 2.4 ångström | x-ray diffraction | J, X | CL | — |
| 5LF1 | Human 20S proteasome complex with Dihydroeponemycin at 2.0 Angstrom | x-ray diffraction | J, X | MG, CL | 2 (best 0.79) |
| 5LF1 | Human 20S proteasome complex with dihydroeponemycin at 2.0 ångström | x-ray diffraction | J, X | CL | — |
| 5LF3 | Human 20S proteasome complex with Bortezomib at 2.1 Angstrom | x-ray diffraction | J, X | MG, CL | 2 (best 0.79) |
| 5LF3 | Human 20S proteasome complex with bortezomib at 2.1 ångström | x-ray diffraction | J, X | CL | — |
| 5LF4 | Human 20S proteasome complex with Delanzomib at 2.0 Angstrom | x-ray diffraction | J, X | CL | — |
| 5LF4 | Human 20S proteasome complex with delanzomib at 2.0 ångström | x-ray diffraction | J, X | CL | — |
| 5LF6 | Human 20S proteasome complex with Z-LLY-ketoaldehyde at 2.1 Angstrom | x-ray diffraction | J, X | MG, NEN, CL | 2 (best 0.77) |
| 5LF6 | Human 20S proteasome complex with Z-lly-ketoaldehyde at 2.1 ångström | x-ray diffraction | J, X | CL, MG | — |
| 5LF7 | Human 20S proteasome complex with Ixazomib at 2.0 Angstrom | x-ray diffraction | J, X | CL | — |
| 5LF7 | Human 20S proteasome complex with ixazomib at 2.0 ångström | x-ray diffraction | J, X | CL | — |
| 5LN3 | The human 26S proteasome at 6.8 ang. | electron microscopy | 4 | — | — |
| 5M32 | Human 26S proteasome in complex with Oprozomib | electron microscopy | J, X | — | 2 (best 0.77) |
| 5M32 | Human 26S proteasome in complex with oprozomib | electron microscopy | J, X | — | — |
| 5T0C | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | AQ, BQ | — | — |
| 5T0G | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | Q | — | 1 (best 0.80) |
| 5T0G | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | Q | — | — |
| 5T0H | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | Q | — | — |
| 5T0I | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | Q | — | — |
| 5T0I | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | Q | — | — |
| 5T0J | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | Q | — | 1 (best 0.80) |
| 5T0J | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | Q | — | — |
| 5VFO | Nucleotide-driven Triple-state Remodeling of the AAA-ATPase Channel in the Activated Human 26S… | electron microscopy | Q, q | — | 2 (best 0.77) |
| 5VFO | Nucleotide-driven triple-state remodeling of the aaa-ATPase channel in the activated human 26S… | electron microscopy | Q, q | — | — |
| 5VFQ | Nucleotide-driven Triple-state Remodeling of the AAA-ATPase Channel in the Activated Human 26S… | electron microscopy | Q, q | — | 1 (best 0.81) |
| 5VFR | Nucleotide-driven triple-state remodeling of the aaa-ATPase channel in the activated human 26S… | electron microscopy | Q, q | — | — |
| 5VFT | Nucleotide-driven triple-state remodeling of the aaa-ATPase channel in the activated human 26S… | electron microscopy | Q, q | — | — |
| 5VFU | Nucleotide-driven Triple-state Remodeling of the AAA-ATPase Channel in the Activated Human 26S… | electron microscopy | Q, q | — | — |
| 6AVO | Cryo-EM structure of human immunoproteasome with a novel noncompetitive inhibitor that selectively… | electron microscopy | T, V | — | 2 (best 0.80) |
| 6AVO | Cryo-EM structure of human immunoproteasome with a novel noncompetitive inhibitor that selectively… | electron microscopy | T, V | — | — |
| 6E5B | Human Immunoproteasome 20S particle in complex with compound 1 | x-ray diffraction | J, X | — | — |
| 6E5B | Human immunoproteasome 20S particle in complex with compound 1 | x-ray diffraction | J, X | — | — |
| 6KWY | human PA200-20S complex | electron microscopy | J, X | — | 3 (best 0.79) |
| 6KWY | Human PA200-20S complex | electron microscopy | J, X | — | — |
| 6MSD | Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome | electron microscopy | Q, q | — | 1 (best 0.79) |
| 6MSE | Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome | electron microscopy | Q, q | — | 1 (best 0.82) |
| 6MSJ | Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome | electron microscopy | Q, q | — | 1 (best 0.79) |
| 6MSK | Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome | electron microscopy | Q, q | — | 1 (best 0.79) |
| 6R70 | Endogeneous native human 20S proteasome | electron microscopy | J, X | — | 2 (best 0.80) |
| 6R70 | Endogeneous native human 20S proteasome | electron microscopy | J, X | — | — |
| 6REY | Human 20S-PA200 proteasome complex | electron microscopy | K, Y | — | — |
| 6RGQ | Human 20S proteasome | electron microscopy | K, Y | — | — |
| 6WJN | SD-like state of human 26S Proteasome with non-cleavable M1-linked hexaubiquitin and E3 ubiquitin… | electron microscopy | Q, q | — | — |
36 records more on the page itself.
Ligands
Elsewhere
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