UniProt P28072
Proteasome subunit beta type-6 (P28072)
Proteasome subunit beta type-6 (UniProt P28072), EC 3.4.25.1: 54 experimental structures on GenesisL1, 11 ligands bound, 14 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P28072
- Protein
- Proteasome subunit beta type-6
- EC
- 3.4.25.1
- Experimental structures
- 54
- Predicted models
- 0
- Ligands
- 11
- Pockets
- 14 · 4 records with a druggable one
Structures
54 records of P28072 in the MolNFT archive: 54 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4R3O | Human Constitutive 20S Proteasome | x-ray diffraction | H, V | — | — |
| 4R3O | Human constitutive 20S proteasome | x-ray diffraction | H, V | — | — |
| 4R67 | Human constitutive 20S proteasome in complex with carfilzomib | x-ray diffraction | H, V, j, x | — | — |
| 4R67 | Human constitutive 20S proteasome in complex with carfilzomib | x-ray diffraction | H, V, j, x | — | — |
| 5A0Q | Cryo-EM reveals the conformation of a substrate analogue in the human 20S proteasome core | electron microscopy | H, V | — | — |
| 5GJQ | Structure of the human 26S proteasome bound to USP14-ubal | electron microscopy | a, o | — | — |
| 5GJR | An atomic structure of the human 26S proteasome | electron microscopy | a, o | — | — |
| 5L4G | The human 26S proteasome at 3.9 A | electron microscopy | Z, 6 | — | — |
| 5LE5 | Native human 20S proteasome at 1.8 Angstrom | x-ray diffraction | N, b | CL, MG, K | — |
| 5LE5 | Native human 20S proteasome at 1.8 ångström | x-ray diffraction | N, b | CL, MG, K | — |
| 5LEX | Native human 20S proteasome in Mg-Acetate at 2.2 Angstrom | x-ray diffraction | N, b | K, MG | — |
| 5LEX | Native human 20S proteasome in mg-acetate at 2.2 ångström | x-ray diffraction | N, b | K, MG | — |
| 5LEY | Human 20S proteasome complex with oprozomib at 1.9 ångström | x-ray diffraction | N, b | CL, MG, K | — |
| 5LEZ | Human 20S proteasome complex with Oprozomib in Mg-Acetate at 2.2 Angstrom | x-ray diffraction | N, b | MG, K | — |
| 5LEZ | Human 20S proteasome complex with oprozomib in mg-acetate at 2.2 ångström | x-ray diffraction | N, b | 6V9, 6VA, MG, K | — |
| 5LF0 | Human 20S proteasome complex with epoxomicin at 2.4 ångström | x-ray diffraction | N, b | 6VO, CL, MG, K | — |
| 5LF1 | Human 20S proteasome complex with dihydroeponemycin at 2.0 ångström | x-ray diffraction | N, b | CL, MG, K, 6VC | — |
| 5LF3 | Human 20S proteasome complex with bortezomib at 2.1 ångström | x-ray diffraction | N, b | CL, MG, K, BO2 | — |
| 5LF4 | Human 20S proteasome complex with Delanzomib at 2.0 Angstrom | x-ray diffraction | N, b | CL, MG, K, 6V7 | — |
| 5LF4 | Human 20S proteasome complex with delanzomib at 2.0 ångström | x-ray diffraction | N, b | CL, MG, K, 6V7 | — |
| 5LF6 | Human 20S proteasome complex with Z-lly-ketoaldehyde at 2.1 ångström | x-ray diffraction | N, b | CL, MG, K | — |
| 5LF7 | Human 20S proteasome complex with Ixazomib at 2.0 Angstrom | x-ray diffraction | N, b | CL, MG, K, 6V8 | — |
| 5LF7 | Human 20S proteasome complex with ixazomib at 2.0 ångström | x-ray diffraction | N, b | CL, MG, K, 6V8 | — |
| 5LN3 | The human 26S proteasome at 6.8 ang. | electron microscopy | 1 | — | — |
| 5M32 | Human 26S proteasome in complex with oprozomib | electron microscopy | N, b | — | — |
| 5T0G | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | N | — | — |
| 5T0G | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | N | — | — |
| 5T0H | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | N | — | — |
| 5T0I | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | N | — | — |
| 5T0J | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | N | — | — |
| 5VFO | Nucleotide-driven triple-state remodeling of the aaa-ATPase channel in the activated human 26S… | electron microscopy | N, n | — | — |
| 5VFR | Nucleotide-driven triple-state remodeling of the aaa-ATPase channel in the activated human 26S… | electron microscopy | N, n | — | — |
| 5VFT | Nucleotide-driven triple-state remodeling of the aaa-ATPase channel in the activated human 26S… | electron microscopy | N, n | — | — |
| 5VFU | Nucleotide-driven Triple-state Remodeling of the AAA-ATPase Channel in the Activated Human 26S… | electron microscopy | N, n | — | — |
| 6KWY | Human PA200-20S complex | electron microscopy | N, b | — | — |
| 6MSD | Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome | electron microscopy | N, n | — | 1 (best 0.79) |
| 6R70 | Endogeneous native human 20S proteasome | electron microscopy | N, b | — | — |
| 6REY | Human 20S-PA200 proteasome complex | electron microscopy | H, V | — | — |
| 6RGQ | Human 20S proteasome | electron microscopy | H, V | — | — |
| 6WJN | Sd-like state of human 26S proteasome with non-cleavable M1-linked hexaubiquitin and E3 ubiquitin… | electron microscopy | N, n | — | — |
| 6XMJ | Human 20S proteasome bound to an engineered 11S (PA26) activator | electron microscopy | H | — | — |
| 7LXV | Structure of human 20S proteasome with bound mpi-5 | electron microscopy | N, b | — | — |
| 7NHT | Akirin2 bound human proteasome | electron microscopy | N | K | — |
| 7NHT | AKIRIN2 bound human proteasome | electron microscopy | N | K | — |
| 7PG9 | Human 20S proteasome | electron microscopy | H, V | — | — |
| 7V5G | 20S+monoUb-CyclinB1-NT (S1) | electron microscopy | A, H | — | 7 (best 0.80) |
| 7V5G | 20S+MONOUB-CYCLINB1-nt (S1) | electron microscopy | A, H | — | — |
| 7V5M | 20S+monoUb-CyclinB1-NT (S2) | electron microscopy | H, V | — | — |
| 7V5M | 20S+MONOUB-CYCLINB1-nt (S2) | electron microscopy | H, V | — | — |
| 7W39 | Structure of USP14-bound human 26S proteasome in state EA2.1_UBL | electron microscopy | N, n | — | — |
| 7W3I | Structure of USP14-bound human 26S proteasome in substrate-inhibited state SB_USP14 | electron microscopy | N, n | — | — |
| 8CVR | Human 20S proteasome with MG-132 | electron microscopy | H, V | LDZ | 4 (best 0.75) |
| 9E8Q | Nub1/Fat10-processing human 26S proteasome with Rpt2 at top of spiral staircase | electron microscopy | N | — | 2 (best 0.75) |
| P28072 | AlphaFold monomer V2.0 prediction for proteasome subunit beta type-6 (P28072) | — | — | — |
Ligands
- K · Potassium ion · in 17 records
- MG · Magnesium ion · in 15 records
- CL · Chloride ion · in 11 records
- 6V7 · [(1~{R})-3-methyl-1-[[(2~{S},3~{S})-3-oxidanyl-2-[(6-phenylpyridin-2-yl) carbonylamino]butanoyl]amino]butyl]boronic acid · in 2 records
- 6V8 · [(1~{R})-1-[2-[[2,5-bis(chloranyl) phenyl]carbonylamino]ethanoylamino]-3-methyl-butyl]boronic acid · in 2 records
- 6V9 · 2-methyl-1,3-thiazole-5-carboxylic acid · in 1 record
- 6VA · (3~{R},4~{S})-4-azanyl-2-methyl-5-phenyl-pentane-2,3-diol · in 1 record
- 6VC · ~{N}-[(2~{S})-1-[[(2~{S},3~{R},4~{S})-2,6-dimethyl-1,2, 3-tris(oxidanyl)heptan-4-yl]amino]-3-oxidanyl-1-oxidanylidene-propan-2-yl]-6-methyl-heptanamide · in 1 record
- 6VO · (3~{R},4~{S})-4-azanyl-2,6-dimethyl-heptane-2,3-diol · in 1 record
- BO2 · N-[(1R)-1-(dihydroxyboryl)-3-methylbutyl]-N-(pyrazin-2-ylcarbonyl)-L-phenylalaninamide · in 1 record
- LDZ · N-[(benzyloxy)carbonyl]-L-leucyl-N-[(2S)-4-methyl-1-oxopentan-2-yl]-L-leucinamide · in 1 record
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.