UniProt P28070
Proteasome subunit beta type-4 (P28070)
Proteasome subunit beta type-4 (UniProt P28070), EC 3.4.25.1: 60 experimental structures on GenesisL1, 1 ligand bound, 15 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P28070
- Protein
- Proteasome subunit beta type-4
- EC
- 3.4.25.1
- Experimental structures
- 60
- Predicted models
- 0
- Ligands
- 1
- Pockets
- 15 · 4 records with a druggable one
Structures
60 records of P28070 in the MolNFT archive: 60 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4R3O | Human Constitutive 20S Proteasome | x-ray diffraction | N, 2 | — | — |
| 4R3O | Human constitutive 20S proteasome | x-ray diffraction | N, 2 | — | — |
| 4R67 | Human constitutive 20S proteasome in complex with carfilzomib | x-ray diffraction | N, 2, p, b | — | — |
| 4R67 | Human constitutive 20S proteasome in complex with carfilzomib | x-ray diffraction | N, 2, p, b | — | — |
| 5A0Q | Cryo-EM reveals the conformation of a substrate analogue in the human 20S proteasome core | electron microscopy | N, b | — | — |
| 5GJQ | Structure of the human 26S proteasome bound to USP14-ubal | electron microscopy | g, u | — | — |
| 5GJR | An atomic structure of the human 26S proteasome | electron microscopy | g, u | — | — |
| 5L4G | The human 26S proteasome at 3.9 A | electron microscopy | X, 4 | — | — |
| 5LE5 | Native human 20S proteasome at 1.8 Angstrom | x-ray diffraction | M, a | CL | — |
| 5LE5 | Native human 20S proteasome at 1.8 ångström | x-ray diffraction | M, a | CL | — |
| 5LEX | Native human 20S proteasome in Mg-Acetate at 2.2 Angstrom | x-ray diffraction | M, a | — | — |
| 5LEX | Native human 20S proteasome in mg-acetate at 2.2 ångström | x-ray diffraction | M, a | — | — |
| 5LEY | Human 20S proteasome complex with oprozomib at 1.9 ångström | x-ray diffraction | M, a | CL | — |
| 5LEZ | Human 20S proteasome complex with Oprozomib in Mg-Acetate at 2.2 Angstrom | x-ray diffraction | M, a | — | — |
| 5LEZ | Human 20S proteasome complex with oprozomib in mg-acetate at 2.2 ångström | x-ray diffraction | M, a | — | — |
| 5LF0 | Human 20S proteasome complex with epoxomicin at 2.4 ångström | x-ray diffraction | M, a | CL | — |
| 5LF1 | Human 20S proteasome complex with dihydroeponemycin at 2.0 ångström | x-ray diffraction | M, a | CL | — |
| 5LF3 | Human 20S proteasome complex with bortezomib at 2.1 ångström | x-ray diffraction | M, a | CL | — |
| 5LF4 | Human 20S proteasome complex with Delanzomib at 2.0 Angstrom | x-ray diffraction | M, a | CL | — |
| 5LF4 | Human 20S proteasome complex with delanzomib at 2.0 ångström | x-ray diffraction | M, a | CL | — |
| 5LF6 | Human 20S proteasome complex with Z-lly-ketoaldehyde at 2.1 ångström | x-ray diffraction | M, a | CL | — |
| 5LF7 | Human 20S proteasome complex with Ixazomib at 2.0 Angstrom | x-ray diffraction | M, a | CL | — |
| 5LF7 | Human 20S proteasome complex with ixazomib at 2.0 ångström | x-ray diffraction | M, a | CL | — |
| 5LN3 | The human 26S proteasome at 6.8 ang. | electron microscopy | 7 | — | — |
| 5M32 | Human 26S proteasome in complex with oprozomib | electron microscopy | M, a | — | — |
| 5T0G | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | T | — | — |
| 5T0G | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | T | — | — |
| 5T0H | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | T | — | — |
| 5T0I | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | T | — | — |
| 5T0J | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | T | — | — |
| 5VFO | Nucleotide-driven triple-state remodeling of the aaa-ATPase channel in the activated human 26S… | electron microscopy | T, t | — | — |
| 5VFR | Nucleotide-driven triple-state remodeling of the aaa-ATPase channel in the activated human 26S… | electron microscopy | T, t | — | — |
| 5VFT | Nucleotide-driven triple-state remodeling of the aaa-ATPase channel in the activated human 26S… | electron microscopy | T, t | — | — |
| 5VFU | Nucleotide-driven Triple-state Remodeling of the AAA-ATPase Channel in the Activated Human 26S… | electron microscopy | T, t | — | — |
| 6AVO | Cryo-EM structure of human immunoproteasome with a novel noncompetitive inhibitor that selectively… | electron microscopy | W, a | — | — |
| 6E5B | Human Immunoproteasome 20S particle in complex with compound 1 | x-ray diffraction | M, a | — | — |
| 6E5B | Human immunoproteasome 20S particle in complex with compound 1 | x-ray diffraction | M, a | — | — |
| 6KWY | Human PA200-20S complex | electron microscopy | M, a | — | — |
| 6MSD | Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome | electron microscopy | T, t | — | 1 (best 0.79) |
| 6R70 | Endogeneous native human 20S proteasome | electron microscopy | M, a | — | — |
| 6REY | Human 20S-PA200 proteasome complex | electron microscopy | N, b | — | — |
| 6RGQ | Human 20S proteasome | electron microscopy | N, b | — | — |
| 6WJN | Sd-like state of human 26S proteasome with non-cleavable M1-linked hexaubiquitin and E3 ubiquitin… | electron microscopy | T, t | — | — |
| 6XMJ | Human 20S proteasome bound to an engineered 11S (PA26) activator | electron microscopy | N | — | — |
| 7AWE | Human immunoproteasome 20S particle in complex with [(1R)-2-(1… | x-ray diffraction | N, b | — | — |
| 7B12 | HUMAN IMMUNOPROTEASOME 20S PARTICLE IN COMPLEX WITH… | x-ray diffraction | 2, N | — | — |
| 7B12 | Human immunoproteasome 20S particle in complex with [2-(3… | x-ray diffraction | 2, N | — | — |
| 7LXV | Structure of human 20S proteasome with bound mpi-5 | electron microscopy | M, a | — | — |
| 7NHT | Akirin2 bound human proteasome | electron microscopy | M | — | — |
| 7NHT | AKIRIN2 bound human proteasome | electron microscopy | M | — | — |
| 7PG9 | Human 20S proteasome | electron microscopy | N, b | — | — |
| 7V5G | 20S+monoUb-CyclinB1-NT (S1) | electron microscopy | G, N | — | 7 (best 0.77) |
| 7V5G | 20S+MONOUB-CYCLINB1-nt (S1) | electron microscopy | G, N | — | — |
| 7V5M | 20S+monoUb-CyclinB1-NT (S2) | electron microscopy | N, b | — | — |
| 7V5M | 20S+MONOUB-CYCLINB1-nt (S2) | electron microscopy | N, b | — | — |
| 7W39 | Structure of USP14-bound human 26S proteasome in state EA2.1_UBL | electron microscopy | T, t | — | — |
| 7W3I | Structure of USP14-bound human 26S proteasome in substrate-inhibited state SB_USP14 | electron microscopy | T, t | — | — |
| 8CVR | Human 20S proteasome with MG-132 | electron microscopy | N, b | — | 6 (best 0.75) |
| 9E8Q | Nub1/Fat10-processing human 26S proteasome with Rpt2 at top of spiral staircase | electron microscopy | T | — | 1 (best 0.74) |
| P28070 | AlphaFold monomer V2.0 prediction for proteasome subunit beta type-4 (P28070) | — | — | — |
Ligands
- CL · Chloride ion · in 11 records
Elsewhere
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