UniProt O14818
Proteasome subunit alpha type-7 (O14818)
Proteasome subunit alpha type-7 (UniProt O14818), EC 3.4.25.1: 69 experimental structures on GenesisL1, 2 ligands bound, 45 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- O14818
- Protein
- Proteasome subunit alpha type-7
- EC
- 3.4.25.1
- Experimental structures
- 69
- Predicted models
- 0
- Ligands
- 2
- Pockets
- 45 · 15 records with a druggable one
Structures
69 records of O14818 in the MolNFT archive: 69 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4R3O | Human Constitutive 20S Proteasome | x-ray diffraction | D, R | — | — |
| 4R3O | Human constitutive 20S proteasome | x-ray diffraction | D, R | — | — |
| 4R67 | Human constitutive 20S proteasome in complex with carfilzomib | x-ray diffraction | D, R, f, t | — | — |
| 4R67 | Human constitutive 20S proteasome in complex with carfilzomib | x-ray diffraction | D, R, f, t | — | — |
| 5A0Q | Cryo-EM reveals the conformation of a substrate analogue in the human 20S proteasome core | electron microscopy | D, R | — | — |
| 5GJQ | Structure of the human 26S proteasome bound to USP14-ubal | electron microscopy | E, k | — | — |
| 5GJR | An atomic structure of the human 26S proteasome | electron microscopy | E, k | — | — |
| 5L4G | The human 26S proteasome at 3.9 A | electron microscopy | Q, D | — | — |
| 5LE5 | Native human 20S proteasome at 1.8 Angstrom | x-ray diffraction | C, Q | CL | — |
| 5LE5 | Native human 20S proteasome at 1.8 ångström | x-ray diffraction | C, Q | CL | — |
| 5LEX | Native human 20S proteasome in Mg-Acetate at 2.2 Angstrom | x-ray diffraction | C, Q | — | — |
| 5LEX | Native human 20S proteasome in mg-acetate at 2.2 ångström | x-ray diffraction | C, Q | — | — |
| 5LEY | Human 20S proteasome complex with oprozomib at 1.9 ångström | x-ray diffraction | C, Q | CL | — |
| 5LEZ | Human 20S proteasome complex with Oprozomib in Mg-Acetate at 2.2 Angstrom | x-ray diffraction | C, Q | — | — |
| 5LEZ | Human 20S proteasome complex with oprozomib in mg-acetate at 2.2 ångström | x-ray diffraction | C, Q | — | — |
| 5LF0 | Human 20S proteasome complex with epoxomicin at 2.4 ångström | x-ray diffraction | C, Q | CL | — |
| 5LF1 | Human 20S proteasome complex with dihydroeponemycin at 2.0 ångström | x-ray diffraction | C, Q | CL | — |
| 5LF3 | Human 20S proteasome complex with Bortezomib at 2.1 Angstrom | x-ray diffraction | C, Q | CL | 4 (best 0.79) |
| 5LF3 | Human 20S proteasome complex with bortezomib at 2.1 ångström | x-ray diffraction | C, Q | CL | — |
| 5LF4 | Human 20S proteasome complex with Delanzomib at 2.0 Angstrom | x-ray diffraction | C, Q | CL | — |
| 5LF4 | Human 20S proteasome complex with delanzomib at 2.0 ångström | x-ray diffraction | C, Q | CL | — |
| 5LF6 | Human 20S proteasome complex with Z-lly-ketoaldehyde at 2.1 ångström | x-ray diffraction | C, Q | CL | — |
| 5LF7 | Human 20S proteasome complex with Ixazomib at 2.0 Angstrom | x-ray diffraction | C, Q | CL | — |
| 5LF7 | Human 20S proteasome complex with ixazomib at 2.0 ångström | x-ray diffraction | C, Q | CL | — |
| 5LN3 | The human 26S proteasome at 6.8 ang. | electron microscopy | D | — | — |
| 5M32 | Human 26S proteasome in complex with oprozomib | electron microscopy | C, Q | — | — |
| 5T0G | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | J | — | 2 (best 0.81) |
| 5T0G | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | J | — | — |
| 5T0H | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | J | — | — |
| 5T0I | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | J | — | — |
| 5T0J | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | J | — | — |
| 5VFO | Nucleotide-driven triple-state remodeling of the aaa-ATPase channel in the activated human 26S… | electron microscopy | J, j | — | — |
| 5VFR | Nucleotide-driven triple-state remodeling of the aaa-ATPase channel in the activated human 26S… | electron microscopy | J, j | — | — |
| 5VFT | Nucleotide-driven triple-state remodeling of the aaa-ATPase channel in the activated human 26S… | electron microscopy | J, j | — | — |
| 5VFU | Nucleotide-driven Triple-state Remodeling of the AAA-ATPase Channel in the Activated Human 26S… | electron microscopy | J, j | — | — |
| 6AVO | Cryo-EM structure of human immunoproteasome with a novel noncompetitive inhibitor that selectively… | electron microscopy | I, N | — | — |
| 6E5B | Human Immunoproteasome 20S particle in complex with compound 1 | x-ray diffraction | C, Q | — | — |
| 6E5B | Human immunoproteasome 20S particle in complex with compound 1 | x-ray diffraction | C, Q | — | — |
| 6KWY | Human PA200-20S complex | electron microscopy | C, Q | — | — |
| 6MSD | Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome | electron microscopy | J, j | — | 3 (best 0.83) |
| 6MSK | Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome | electron microscopy | J, j | — | 2 (best 0.81) |
| 6R70 | Endogeneous native human 20S proteasome | electron microscopy | C, Q | — | — |
| 6REY | Human 20S-PA200 proteasome complex | electron microscopy | D, R | — | — |
| 6RGQ | Human 20S proteasome | electron microscopy | D, R | — | — |
| 6WJN | Sd-like state of human 26S proteasome with non-cleavable M1-linked hexaubiquitin and E3 ubiquitin… | electron microscopy | J, j | — | — |
| 6XMJ | Human 20S proteasome bound to an engineered 11S (PA26) activator | electron microscopy | D | — | — |
| 7AWE | Human immunoproteasome 20S particle in complex with [(1R)-2-(1… | x-ray diffraction | D, R | — | — |
| 7B12 | HUMAN IMMUNOPROTEASOME 20S PARTICLE IN COMPLEX WITH… | x-ray diffraction | D, r | SO4 | — |
| 7B12 | Human immunoproteasome 20S particle in complex with [2-(3… | x-ray diffraction | D, r | SO4 | — |
| 7LXV | Structure of human 20S proteasome with bound mpi-5 | electron microscopy | C, Q | — | — |
| 7NHT | Akirin2 bound human proteasome | electron microscopy | C | — | — |
| 7NHT | AKIRIN2 bound human proteasome | electron microscopy | C | — | — |
| 7PG9 | Human 20S proteasome | electron microscopy | D, R | — | — |
| 7QY7 | Proteasome-ZFAND5 Complex Z-A state | electron microscopy | J, j | — | 4 (best 0.82) |
| 7V5G | 20S+monoUb-CyclinB1-NT (S1) | electron microscopy | Y, R | — | 2 (best 0.77) |
| 7V5G | 20S+MONOUB-CYCLINB1-nt (S1) | electron microscopy | Y, R | — | — |
| 7V5M | 20S+monoUb-CyclinB1-NT (S2) | electron microscopy | D, R | — | — |
| 7V5M | 20S+MONOUB-CYCLINB1-nt (S2) | electron microscopy | D, R | — | — |
| 7W39 | Structure of USP14-bound human 26S proteasome in state EA2.1_UBL | electron microscopy | J, j | — | 2 (best 0.81) |
| 7W3B | Structure of USP14-bound human 26S proteasome in substrate-engaged state ED5_USP14 | electron microscopy | J, j | — | 1 (best 0.78) |
9 records more on the page itself.
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