UniProt P20618
Proteasome subunit beta type-1 (P20618)
Proteasome subunit beta type-1 (UniProt P20618), EC 3.4.25.1: 101 experimental structures on GenesisL1, 26 ligands bound, 26 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P20618
- Protein
- Proteasome subunit beta type-1
- EC
- 3.4.25.1
- Experimental structures
- 101
- Predicted models
- 0
- Ligands
- 26
- Pockets
- 26 · 7 records with a druggable one
Structures
101 records of P20618 in the MolNFT archive: 101 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4R3O | Human Constitutive 20S Proteasome | x-ray diffraction | M, 1 | — | — |
| 4R3O | Human constitutive 20S proteasome | x-ray diffraction | M, 1 | — | — |
| 4R67 | Human constitutive 20S proteasome in complex with carfilzomib | x-ray diffraction | M, 1, o, a | — | — |
| 4R67 | Human constitutive 20S proteasome in complex with carfilzomib | x-ray diffraction | M, 1, o, a | — | — |
| 5A0Q | Cryo-EM reveals the conformation of a substrate analogue in the human 20S proteasome core | electron microscopy | M, a | — | — |
| 5GJQ | Structure of the human 26S proteasome bound to USP14-ubal | electron microscopy | f, t | — | — |
| 5GJR | An atomic structure of the human 26S proteasome | electron microscopy | f, t | — | — |
| 5L4G | The human 26S proteasome at 3.9 A | electron microscopy | U, 1 | — | — |
| 5L5B | Yeast 20S proteasome with human BETA5I (1-138) and human BETA6 (97- 111; 118-133) | x-ray diffraction | L, Z | MG | — |
| 5L5D | Yeast 20S proteasome with human BETA5I (1-138) and human BETA6 (97- 111; 118-133) in complex with… | x-ray diffraction | L, Z | 04C, MG | — |
| 5L5E | Yeast 20S proteasome with human beta5i (1-138) and human beta6 (97-111; 118-133) in complex with… | x-ray diffraction | L, Z | 3BV, MG | — |
| 5L5E | Yeast 20S proteasome with human BETA5I (1-138) and human BETA6 (97- 111; 118-133) in complex with… | x-ray diffraction | L, Z | 3BV, MG | — |
| 5L5F | Yeast 20S proteasome with human beta5i (1-138) and human beta6 (97-111; 118-133) in complex with… | x-ray diffraction | L, Z | BO2, MG | — |
| 5L5F | Yeast 20S proteasome with human BETA5I (1-138) and human BETA6 (97- 111; 118-133) in complex with… | x-ray diffraction | L, Z | BO2, MG | — |
| 5L5H | Yeast 20S proteasome with human BETA5I (1-138) and human BETA6 (97- 111; 118-133) in complex with… | x-ray diffraction | L, Z | 39V, MG | — |
| 5L5I | Yeast 20S proteasome with human BETA5I (1-138) and human BETA6 (97- 111; 118-133) in complex with… | x-ray diffraction | L, Z | 38X, MG | — |
| 5L5J | Yeast 20S proteasome with human BETA5I (1-138) and human BETA6 (97- 111; 118-133) in complex with… | x-ray diffraction | L, Z | 6N5, MG | — |
| 5L5O | Yeast 20S proteasome with human beta5i (1-138) and human beta6 (97-111; 118-133) in complex with… | x-ray diffraction | L, Z | 79P, MG | — |
| 5L5O | Yeast 20S proteasome with human BETA5I (1-138) and human BETA6 (97- 111; 118-133) in complex with… | x-ray diffraction | L, Z | 79P, MG | — |
| 5L5P | Yeast 20S proteasome with human beta5i (1-138) and human beta6 (97-111; 118-133) in complex with… | x-ray diffraction | L, Z | 79L, MG | — |
| 5L5P | Yeast 20S proteasome with human BETA5I (1-138) and human BETA6 (97- 111; 118-133) in complex with… | x-ray diffraction | L, Z | 79L, MG | — |
| 5L5Q | Yeast 20S proteasome with human BETA5I (1-138) and human BETA6 (97- 111; 118-133) in complex with… | x-ray diffraction | L, Z | 6NV, MG | — |
| 5L5R | Yeast 20S proteasome with human BETA5I (1-138;V31M) and human BETA6 (97-111; 118-133) | x-ray diffraction | L, Z | MG | — |
| 5L5S | Yeast 20S proteasome with human beta5i (1-138; V31M) and human beta6 (97-111; 118-133) in complex… | x-ray diffraction | L, Z | 39V, MG | — |
| 5L5S | Yeast 20S proteasome with human BETA5I (1-138; V31M) and human BETA6 (97-111; 118-133) in complex… | x-ray diffraction | L, Z | 39V, MG | — |
| 5L5T | Yeast 20S proteasome with human beta5i (1-138; V31M) and human beta6 (97-111; 118-133) in complex… | x-ray diffraction | L, Z | 79P, MG | — |
| 5L5T | Yeast 20S proteasome with human BETA5I (1-138; V31M) and human BETA6 (97-111; 118-133) in complex… | x-ray diffraction | L, Z | 79P, MG | — |
| 5L5U | Yeast 20S proteasome with human BETA5I (1-138; V31M) and human BETA6 (97-111; 118-133) in complex… | x-ray diffraction | L, Z | 04C, MG | — |
| 5L5V | 'yeast 20S proteasome with human BETA5I (1-138; V31M) and human BETA6 (97-111; 118-133) in complex… | x-ray diffraction | L, Z | 6NV, MG | — |
| 5L5W | Yeast 20S proteasome with human beta5c (1-138) and human beta6 (97-111; 118-133) | x-ray diffraction | L, Z | MG | — |
| 5L5W | Yeast 20S proteasome with human BETA5C (1-138) and human BETA6 (97- 111; 118-133) | x-ray diffraction | L, Z | MG | — |
| 5L5X | Yeast 20S proteasome with human beta5c (1-138) and human beta6 (97-111; 118-133) in complex with… | x-ray diffraction | L, Z | 04C, MG | — |
| 5L5X | Yeast 20S proteasome with human BETA5C (1-138) and human BETA6 (97- 111; 118-133) in complex with… | x-ray diffraction | L, Z | 04C, MG | — |
| 5L5Y | Yeast 20S proteasome with human BETA5C (1-138) and human BETA6 (97- 111; 118-133) in complex with… | x-ray diffraction | L, Z | 3BV, MG | — |
| 5L5Z | Yeast 20S proteasome with human beta5c (1-138) and human beta6 (97-111; 118-133) in complex with… | x-ray diffraction | L, Z | BO2, MG | 6 (best 0.83) |
| 5L5Z | Yeast 20S proteasome with human BETA5C (1-138) and human BETA6 (97- 111; 118-133) in complex with… | x-ray diffraction | L, Z | BO2, MG | — |
| 5L60 | Yeast 20S proteasome with human BETA5C (1-138) and human BETA6 (97- 111; 118-133) in complex with… | x-ray diffraction | L, Z | 39V, MG | — |
| 5L61 | Yeast 20S proteasome with human beta5c (1-138) and human beta6 (99-132) in complex with epoxyketone… | x-ray diffraction | L, Z | 6N5, MG | — |
| 5L61 | Yeast 20S proteasome with human BETA5C (1-138) and human BETA6 (99- 132) in complex with… | x-ray diffraction | L, Z | 6N5, MG | — |
| 5L62 | Yeast 20S proteasome with human beta5c (1-138) and human beta6 (97-111; 118-133) in complex with… | x-ray diffraction | L, Z | 79P, MG | 6 (best 0.75) |
| 5L62 | Yeast 20S proteasome with human BETA5C (1-138) and human BETA6 (97- 111; 118-133) in complex with… | x-ray diffraction | L, Z | 79P, MG | — |
| 5L63 | Yeast 20S proteasome with human BETA5C (1-138) and human BETA6 (97- 111; 118-133) in complex with… | x-ray diffraction | L, Z | 04C, MG | — |
| 5L64 | Yeast 20S proteasome with human BETA5C (1-138) and human BETA6 (97- 111; 118-133) in complex with… | x-ray diffraction | L, Z | 6NV, MG | — |
| 5LE5 | Native human 20S proteasome at 1.8 Angstrom | x-ray diffraction | L, Z | MG, K | — |
| 5LE5 | Native human 20S proteasome at 1.8 ångström | x-ray diffraction | L, Z | MG, K | — |
| 5LEX | Native human 20S proteasome in Mg-Acetate at 2.2 Angstrom | x-ray diffraction | L, Z | MG, K | — |
| 5LEX | Native human 20S proteasome in mg-acetate at 2.2 ångström | x-ray diffraction | L, Z | MG, K | — |
| 5LEY | Human 20S proteasome complex with oprozomib at 1.9 ångström | x-ray diffraction | L, Z | 6V9, MG, K | — |
| 5LEZ | Human 20S proteasome complex with Oprozomib in Mg-Acetate at 2.2 Angstrom | x-ray diffraction | L, Z | MG, K | — |
| 5LEZ | Human 20S proteasome complex with oprozomib in mg-acetate at 2.2 ångström | x-ray diffraction | L, Z | 6V9, MG, K | — |
| 5LF0 | Human 20S proteasome complex with epoxomicin at 2.4 ångström | x-ray diffraction | L, Z | ACE, MG, K | — |
| 5LF1 | Human 20S proteasome complex with dihydroeponemycin at 2.0 ångström | x-ray diffraction | L, Z | MG, 6VC, K | — |
| 5LF3 | Human 20S proteasome complex with Bortezomib at 2.1 Angstrom | x-ray diffraction | L, Z | MG, BO2, K | 3 (best 0.80) |
| 5LF3 | Human 20S proteasome complex with bortezomib at 2.1 ångström | x-ray diffraction | L, Z | MG, BO2, K | — |
| 5LF4 | Human 20S proteasome complex with Delanzomib at 2.0 Angstrom | x-ray diffraction | L, Z | MG, 6V7, K | — |
| 5LF4 | Human 20S proteasome complex with delanzomib at 2.0 ångström | x-ray diffraction | L, Z | MG, 6V7, K | — |
| 5LF6 | Human 20S proteasome complex with Z-lly-ketoaldehyde at 2.1 ångström | x-ray diffraction | L, Z | 6VF, MG, PHQ, K | — |
| 5LF7 | Human 20S proteasome complex with Ixazomib at 2.0 Angstrom | x-ray diffraction | L, Z | MG, 6V8, K | — |
| 5LF7 | Human 20S proteasome complex with ixazomib at 2.0 ångström | x-ray diffraction | L, Z | MG, 6V8, K | — |
| 5LN3 | The human 26S proteasome at 6.8 ang. | electron microscopy | 6 | — | — |
41 records more on the page itself.
Ligands
- MG · Magnesium ion · in 51 records
- K · Potassium ion · in 18 records
- 79P · (2~{S})-3-(1~{H}-indol-3-yl)-~{N}-[(2~{S},3~{S},4~{R})-4-methyl-3,5-bis(oxidanyl)-1-phenyl-pentan-2-yl]-2-[[(2~{R})-2-(2-morpholin-4-ylethanoylamino) propanoyl]amino]propanamide · in 6 records
- BO2 · N-[(1R)-1-(dihydroxyboryl)-3-methylbutyl]-N-(pyrazin-2-ylcarbonyl)-L-phenylalaninamide · in 6 records
- 04C · 1,2,4-trideoxy-4-methyl-2-{[N-(morpholin-4-ylacetyl)-L-alanyl-O-methyl-L-tyrosyl]amino}-1-phenyl-D-xylitol · in 5 records
- NA · Sodium ion · in 5 records
- 39V · N-[(3-methyl-1H-inden-2-yl)carbonyl]-D-alanyl-N-[(2S, 4R)-5-hydroxy-4-methyl-3-oxo-1-phenylpentan-2-yl]-L-tryptophanamide · in 4 records
- 3BV · N-{(2S)-2-[(morpholin-4-ylacetyl)amino]-4-phenylbutanoyl}-L-leucyl-N-[(2R,3S,4S)-1,3-dihydroxy-2,6-dimethylheptan-4-yl]-L-phenylalaninamide · in 3 records
- 6N5 · ~{N}-[(2~{S})-1-[[(2~{S})-3-(4-methoxyphenyl)-1-[[(2~{S},3~{S},4~{R})-4-methyl-3,5-bis(oxidanyl)-1-phenyl-pentan-2-yl]amino]-1-oxidanylidene-propan-2-yl]amino]-1-oxidanylidene-propan-2-yl]-1-methyl-5~{H}-indene-2-carboxamide · in 3 records
- 6NV · ~{N}-[(2~{R})-1-[[(2~{S})-3-(4-methoxyphenyl)-1-[[(2~{S},3~{S},4~{R})-4-methyl-3,5-bis(oxidanyl)-1-phenyl-pentan-2-yl]amino]-1-oxidanylidene-propan-2-yl]amino]-1-oxidanylidene-propan-2-yl]-1-methyl-5~{H}-indene-2-carboxamide · in 3 records
- 6V9 · 2-methyl-1,3-thiazole-5-carboxylic acid · in 3 records
- SCN · Thiocyanate ion · in 3 records
- 6V7 · [(1~{R})-3-methyl-1-[[(2~{S},3~{S})-3-oxidanyl-2-[(6-phenylpyridin-2-yl) carbonylamino]butanoyl]amino]butyl]boronic acid · in 2 records
- 6V8 · [(1~{R})-1-[2-[[2,5-bis(chloranyl) phenyl]carbonylamino]ethanoylamino]-3-methyl-butyl]boronic acid · in 2 records
- 79L · (2~{S})-3-(4-methoxyphenyl)-~{N}-[(2~{S},3~{S},4~{R})-4-methyl-3,5-bis(oxidanyl)-1-phenyl-pentan-2-yl]-2-[[(2~{R})-2-(2-morpholin-4-ylethanoylamino) propanoyl]amino]propanamide · in 2 records
- SKN · ((R)-2-(3-ethylphenyl)-1-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)ethyl)boronic acid · in 2 records
- SO4 · Sulfate ion · in 2 records
- 38X · N-[(3-methyl-1H-inden-2-yl)carbonyl]-D-alanyl-N-[(2S, 4R)-1-cyclohexyl-5-hydroxy-4-methyl-3-oxopentan-2-yl]-L-tryptophanamide · in 1 record
- 6VC · ~{N}-[(2~{S})-1-[[(2~{S},3~{R},4~{S})-2,6-dimethyl-1,2, 3-tris(oxidanyl)heptan-4-yl]amino]-3-oxidanyl-1-oxidanylidene-propan-2-yl]-6-methyl-heptanamide · in 1 record
- 6VF · (2~{R},3~{S})-3-azanyl-4-(4-hydroxyphenyl)butane-1,2-diol · in 1 record
- 7C9 · O-methyl-L-serine · in 1 record
- ACE · Acetyl group · in 1 record
- LDZ · N-[(benzyloxy)carbonyl]-L-leucyl-N-[(2S)-4-methyl-1-oxopentan-2-yl]-L-leucinamide · in 1 record
- PHQ · benzyl chlorocarbonate · in 1 record
- YHD · N-[(1R)-2-([1,1'-biphenyl]-4-yl)-1-boronoethyl]-1-methyl-L-prolinamide · in 1 record
- YRE · (7S,10S,13S)-N-cyclopentyl-10-[2-(morpholin-4-yl)ethyl]-9,12-dioxo-13-(2-oxopyrrolidin-1-yl)-2-oxa-8,11-diazabicyclo[13.3.1]nonadeca-1(19),15,17-triene-7-carboxamide · in 1 record
Elsewhere
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