UniProt O00231
26S proteasome non-ATPase regulatory subunit 11 (O00231)
26S proteasome non-ATPase regulatory subunit 11 (UniProt O00231): 46 experimental structures and 1 predicted model on GenesisL1, 40 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O00231
- Protein
- 26S proteasome non-ATPase regulatory subunit 11
- Experimental structures
- 46
- Predicted models
- 1
- Pockets
- 40 · 19 records with a druggable one
Structures
47 records of O00231 in the MolNFT archive: 46 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5GJQ | Structure of the human 26S proteasome bound to USP14-ubal | electron microscopy | Q | — | — |
| 5GJR | An atomic structure of the human 26S proteasome | electron microscopy | Q, 4 | — | — |
| 5L4K | The human 26S proteasome lid | electron microscopy | Q | — | — |
| 5LN3 | The human 26S proteasome at 6.8 ang. | electron microscopy | Q | — | — |
| 5M32 | Human 26S proteasome in complex with Oprozomib | electron microscopy | l | — | 3 (best 0.79) |
| 5M32 | Human 26S proteasome in complex with oprozomib | electron microscopy | l | — | — |
| 5T0G | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | X | — | — |
| 5T0G | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | X | — | — |
| 5T0H | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | X | — | — |
| 5T0I | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | X | — | — |
| 5T0I | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | X | — | — |
| 5T0J | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | X | — | 2 (best 0.86) |
| 5T0J | Structural basis for dynamic regulation of the human 26S proteasome | electron microscopy | X | — | — |
| 5VFQ | Nucleotide-driven Triple-state Remodeling of the AAA-ATPase Channel in the Activated Human 26S… | electron microscopy | X | — | 2 (best 0.83) |
| 5VFR | Nucleotide-driven triple-state remodeling of the aaa-ATPase channel in the activated human 26S… | electron microscopy | X | — | — |
| 5VFT | Nucleotide-driven triple-state remodeling of the aaa-ATPase channel in the activated human 26S… | electron microscopy | X | — | — |
| 5VFU | Nucleotide-driven Triple-state Remodeling of the AAA-ATPase Channel in the Activated Human 26S… | electron microscopy | X | — | — |
| 5VGZ | Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle | electron microscopy | X | — | 3 (best 0.87) |
| 5VGZ | Conformational landscape of the P28-bound human proteasome regulatory particle | electron microscopy | X | — | — |
| 5VHF | Conformational landscape of the P28-bound human proteasome regulatory particle | electron microscopy | X | — | — |
| 5VHH | Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle | electron microscopy | X | — | 2 (best 0.87) |
| 5VHH | Conformational landscape of the P28-bound human proteasome regulatory particle | electron microscopy | X | — | — |
| 5VHI | Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle | electron microscopy | X | — | 2 (best 0.83) |
| 5VHI | Conformational landscape of the P28-bound human proteasome regulatory particle | electron microscopy | X | — | — |
| 5VHS | Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle | electron microscopy | X | — | 2 (best 0.84) |
| 5VHS | Conformational landscape of the P28-bound human proteasome regulatory particle | electron microscopy | X | — | — |
| 6MSD | Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome | electron microscopy | X | — | 1 (best 0.82) |
| 6MSJ | Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome | electron microscopy | X | — | 1 (best 0.88) |
| 6MSK | Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome | electron microscopy | X | — | — |
| 6WJN | SD-like state of human 26S Proteasome with non-cleavable M1-linked hexaubiquitin and E3 ubiquitin… | electron microscopy | X | — | 2 (best 0.85) |
| 6WJN | Sd-like state of human 26S proteasome with non-cleavable M1-linked hexaubiquitin and E3 ubiquitin… | electron microscopy | X | — | — |
| 7QXP | Proteasome-ZFAND5 Complex Z+B state | electron microscopy | X | — | — |
| 7QXX | Proteasome-ZFAND5 Complex Z+E state | electron microscopy | X | — | — |
| 7QY7 | Proteasome-ZFAND5 Complex Z-A state | electron microscopy | X | — | 1 (best 0.81) |
| 7W37 | Structure of USP14-bound human 26S proteasome in state EA1_UBL | electron microscopy | X | — | — |
| 7W38 | Structure of USP14-bound human 26S proteasome in state EA2.0_UBL | electron microscopy | X | — | 1 (best 0.82) |
| 7W39 | Structure of USP14-bound human 26S proteasome in state EA2.1_UBL | electron microscopy | X | — | 1 (best 0.79) |
| 7W3B | Structure of USP14-bound human 26S proteasome in substrate-engaged state ED5_USP14 | electron microscopy | X | — | 3 (best 0.86) |
| 7W3H | Structure of USP14-bound human 26S proteasome in substrate-engaged state ED2.1_USP14 | electron microscopy | X | — | 1 (best 0.79) |
| 7W3I | Structure of USP14-bound human 26S proteasome in substrate-inhibited state SB_USP14 | electron microscopy | X | — | — |
| 8CVT | Human 19S-20S proteasome, state SD2 | electron microscopy | X | — | 3 (best 0.79) |
| 8JRI | Cryo-EM structure of human 26S proteasomal RP subcomplex (Ea state) without any bound substrate. | electron microscopy | X | — | — |
| 9E8I | Human proteasome in resting state conformation bound to TXNL1 in Forward conformation | electron microscopy | X | — | — |
| 9E8L | Nub1/Fat10-processing human 26S proteasome bound to Txnl1 with Rpt4 at top of spiral staircase | electron microscopy | X | — | 2 (best 0.86) |
| 9E8N | Nub1/Fat10-processing human 26S proteasome bound to Txnl1 with Rpt3 at top of spiral staircase | electron microscopy | X | — | 3 (best 0.80) |
| 9E8Q | Nub1/Fat10-processing human 26S proteasome with Rpt2 at top of spiral staircase | electron microscopy | X | — | 1 (best 0.79) |
| O00231 | AlphaFold monomer V2.0 prediction for 26S proteasome non-ATPase regulatory subunit 11 (O00231) | predicted | A | — | 4 (best 0.48) |
Experiment against prediction
- 7W39 chain X against the predicted model O00231: TM-score 0.87, RMSD 3.15 Å
- 9E8I chain X against the predicted model O00231: TM-score 0.86, RMSD 3.09 Å
- 5GJQ chain Q against the predicted model O00231: TM-score 0.85, RMSD 3.33 Å
- 5GJR chain Q against the predicted model O00231: TM-score 0.85, RMSD 3.42 Å
- 9E8L chain X against the predicted model O00231: TM-score 0.85, RMSD 2.42 Å
- 7QXX chain X against the predicted model O00231: TM-score 0.85, RMSD 1.79 Å
- 5M32 chain l against the predicted model O00231: TM-score 0.84, RMSD 3.38 Å
- 5M32 chain l against the predicted model O00231: TM-score 0.84, RMSD 3.38 Å
- 6MSD chain X against the predicted model O00231: TM-score 0.84, RMSD 3.47 Å
- 9E8N chain X against the predicted model O00231: TM-score 0.84, RMSD 2.55 Å
Elsewhere
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